Navigation Links
Novel Method Eyed for Normalizing Blood Sugar
Date:3/30/2010

Working with mice, diabetes researchers reactivate key cellular pathway

TUESDAY, March 30 (HealthDay News) -- A potential new method of normalizing blood sugar levels in diabetes has been discovered by U.S. researchers.

The Children's Hospital Boston team identified a cellular pathway that fails because of obesity. Artificial activation of this pathway normalized glucose levels in severely obese and diabetic mice, according to the report published online March 28 in Nature Medicine.

Previously, the researchers found that the brain, liver and fat cells of obese mice have increased stress in the endoplasmic reticulum (ER), which produces proteins. Obesity overwhelms the ER and causes it to malfunction. This so-called "ER stress" triggers a series of events that suppresses the body's response to insulin, making ER stress an important link between obesity and type 2 diabetes.

In this new study, the researchers found that a transcription factor that normally helps relieve ER stress -- called X-box binding protein 1 (XBP-1) -- can't function in obese mice. They also found that obesity affects a protein fragment called p85 that plays a key role in the ability of XBP-1 to relieve ER stress.

According to Dr. Umut Ozcan and colleagues, insulin signaling that would normally increase the levels of free p85 is impaired in obesity. This leads to an increase in ER stress and more insulin resistance, which eventually causes type 2 diabetes. However, increasing levels of free p85 may prevent this from occurring, the researchers said.

More information

The U.S. National Diabetes Education Program explains how to prevent diabetes.



-- Robert Preidt



SOURCE: Children's Hospital Boston, news release, March 28, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Novel Parkinson's Treatment Strategy Involves Cell Transplantation
2. MessageSolution First in the Market to Offer All-in-One, Integrated Cloud-Based Archiving for Email, File Systems and SharePoint at Novell BrainShare 2010
3. Novel medical home program for pediatric patients, families cuts ER visits in half
4. Novel stroke treatment passes safety stage of UCI-led clinical trial
5. Reovirus may be a novel approach to prostate cancer treatment
6. Novel program translates behavioral and social science research into treatments to reduce obesity
7. A novel in vitro model for light-induced wound healing
8. NIH grants to Childrens Hospital will advance novel stem cell treatments for blood disorders
9. New Study Demonstrates Novel Use of Metabolic Imaging to Locate Sperm in Infertile Men -- Non-Invasive Imaging Procedure May Replace Invasive Techniques such as Testicula
10. Novelty lures rats from cocaine-paired settings, hinting at new treatments for recovering addicts
11. A novel computational model -- how Parkinsons medications affect learning and attention
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... (PRWEB) , ... June 27, ... ... in the patient payment industry today announced its strategic partnership with Connance, ... system workflows. , The two companies’ proven, proprietary technology combine to provide ...
(Date:6/26/2016)... California (PRWEB) , ... June 26, 2016 , ... Pixel ... Cut Pro X. , "Film editors can give their videos a whole new perspective ... Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over ...
(Date:6/25/2016)... ... , ... Austin residents seeking Mohs surgery services, can now turn to Dr. ... Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to include ... in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is ... associated with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: RO, ... clearance for its Elecsys BRAHMS PCT (procalcitonin) assay as ... or septic shock. With this clearance, Roche is the ... fully integrated solution for sepsis risk assessment and management. ... bacterial infection and PCT levels in blood can aid ...
(Date:6/23/2016)... , June 23, 2016 Research and ... News Issue 52" report to their offering. ... influenza treatment creates a favourable commercial environment for MedImmune to ... patient base that will serve to drive considerable growth for ... would serve to cap sales considerably, but development is still ...
(Date:6/23/2016)... PARK RIDGE, Ill. and INDIANAPOLIS ... caliber of students receiving a Lilly Diabetes Tomorrow,s Leaders ... hands. The 2016 scholarship winners, announced today online at ... refused to let type 1 diabetes stand in the ... Lilly Diabetes has supported the Foundation,s scholarship program since ...
Breaking Medicine Technology: