Navigation Links
Novel Method Eyed for Normalizing Blood Sugar
Date:3/30/2010

Working with mice, diabetes researchers reactivate key cellular pathway

TUESDAY, March 30 (HealthDay News) -- A potential new method of normalizing blood sugar levels in diabetes has been discovered by U.S. researchers.

The Children's Hospital Boston team identified a cellular pathway that fails because of obesity. Artificial activation of this pathway normalized glucose levels in severely obese and diabetic mice, according to the report published online March 28 in Nature Medicine.

Previously, the researchers found that the brain, liver and fat cells of obese mice have increased stress in the endoplasmic reticulum (ER), which produces proteins. Obesity overwhelms the ER and causes it to malfunction. This so-called "ER stress" triggers a series of events that suppresses the body's response to insulin, making ER stress an important link between obesity and type 2 diabetes.

In this new study, the researchers found that a transcription factor that normally helps relieve ER stress -- called X-box binding protein 1 (XBP-1) -- can't function in obese mice. They also found that obesity affects a protein fragment called p85 that plays a key role in the ability of XBP-1 to relieve ER stress.

According to Dr. Umut Ozcan and colleagues, insulin signaling that would normally increase the levels of free p85 is impaired in obesity. This leads to an increase in ER stress and more insulin resistance, which eventually causes type 2 diabetes. However, increasing levels of free p85 may prevent this from occurring, the researchers said.

More information

The U.S. National Diabetes Education Program explains how to prevent diabetes.



-- Robert Preidt



SOURCE: Children's Hospital Boston, news release, March 28, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Novel Parkinson's Treatment Strategy Involves Cell Transplantation
2. MessageSolution First in the Market to Offer All-in-One, Integrated Cloud-Based Archiving for Email, File Systems and SharePoint at Novell BrainShare 2010
3. Novel medical home program for pediatric patients, families cuts ER visits in half
4. Novel stroke treatment passes safety stage of UCI-led clinical trial
5. Reovirus may be a novel approach to prostate cancer treatment
6. Novel program translates behavioral and social science research into treatments to reduce obesity
7. A novel in vitro model for light-induced wound healing
8. NIH grants to Childrens Hospital will advance novel stem cell treatments for blood disorders
9. New Study Demonstrates Novel Use of Metabolic Imaging to Locate Sperm in Infertile Men -- Non-Invasive Imaging Procedure May Replace Invasive Techniques such as Testicula
10. Novelty lures rats from cocaine-paired settings, hinting at new treatments for recovering addicts
11. A novel computational model -- how Parkinsons medications affect learning and attention
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/17/2017)... ... August 17, 2017 , ... In its just released 2018 ... and Harry Nelson. This is the third consecutive year that Hardiman and Mills have ... were both recognized for expertise in Health Care Law while Mills was recognized in ...
(Date:8/17/2017)... ... August 17, 2017 , ... An August 2 article on NextShark ... surgery, largely influenced by the growing popularity of “pretty boys” in both K-Pop and ... standards of male appearance are changing not only in the Asian nation, where plastic ...
(Date:8/17/2017)... ... 17, 2017 , ... Inc. Magazine Unveils 36th Annual List of America’s Fastest-Growing ... Growth of 3,004.8% , NEW YORK, August 16, 2017 – Inc. magazine today ranked ... of the nation's fastest-growing private companies. The list represents a unique look at the ...
(Date:8/17/2017)... , ... August 17, 2017 , ... Centrifugation is more ... in the laboratory that we can no longer do without. And just like a ... of your device. , In this webinar, attendees will learn about the most important ...
(Date:8/16/2017)... (PRWEB) , ... August 16, 2017 , ... Summer days ... Island’s original family-owned supermarket, has put together suggestions for enjoying the season of sunshine. ... or activity, everyone in the family can join in on the fun. , ...
Breaking Medicine News(10 mins):
(Date:8/1/2017)... Aug. 1, 2017   CerSci Therapeutics , a ... Texas , has received notice from the National ... of Health (NIH) that it has been awarded a ... over $650,000 in 2017 with an additional $1,000,000 to ... New Drug application of their lead non-opioid drug candidate ...
(Date:7/28/2017)... --EnvoyHealth, a Diplomat company, has partnered with Compliance Meds ... a technology designed to improve patient medication adherence. ... solutions and services that help track and improve patients, ... LITE offers medication monitoring and control for patients and ... Records date and time of bottle ...
(Date:7/26/2017)... BEACH, Fla. , July 26, 2017 ... of enrollment of our clinical trial evaluating Altemia TM ... Cell Anemia (SCA) and Sickle Cell Disease (SCD). The ... to evaluate the efficacy and safety of Altemia TM ... trial is conducted under US IND 125274. ...
Breaking Medicine Technology: