Navigation Links
Novel Method Eyed for Normalizing Blood Sugar
Date:3/30/2010

Working with mice, diabetes researchers reactivate key cellular pathway

TUESDAY, March 30 (HealthDay News) -- A potential new method of normalizing blood sugar levels in diabetes has been discovered by U.S. researchers.

The Children's Hospital Boston team identified a cellular pathway that fails because of obesity. Artificial activation of this pathway normalized glucose levels in severely obese and diabetic mice, according to the report published online March 28 in Nature Medicine.

Previously, the researchers found that the brain, liver and fat cells of obese mice have increased stress in the endoplasmic reticulum (ER), which produces proteins. Obesity overwhelms the ER and causes it to malfunction. This so-called "ER stress" triggers a series of events that suppresses the body's response to insulin, making ER stress an important link between obesity and type 2 diabetes.

In this new study, the researchers found that a transcription factor that normally helps relieve ER stress -- called X-box binding protein 1 (XBP-1) -- can't function in obese mice. They also found that obesity affects a protein fragment called p85 that plays a key role in the ability of XBP-1 to relieve ER stress.

According to Dr. Umut Ozcan and colleagues, insulin signaling that would normally increase the levels of free p85 is impaired in obesity. This leads to an increase in ER stress and more insulin resistance, which eventually causes type 2 diabetes. However, increasing levels of free p85 may prevent this from occurring, the researchers said.

More information

The U.S. National Diabetes Education Program explains how to prevent diabetes.



-- Robert Preidt



SOURCE: Children's Hospital Boston, news release, March 28, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Novel Parkinson's Treatment Strategy Involves Cell Transplantation
2. MessageSolution First in the Market to Offer All-in-One, Integrated Cloud-Based Archiving for Email, File Systems and SharePoint at Novell BrainShare 2010
3. Novel medical home program for pediatric patients, families cuts ER visits in half
4. Novel stroke treatment passes safety stage of UCI-led clinical trial
5. Reovirus may be a novel approach to prostate cancer treatment
6. Novel program translates behavioral and social science research into treatments to reduce obesity
7. A novel in vitro model for light-induced wound healing
8. NIH grants to Childrens Hospital will advance novel stem cell treatments for blood disorders
9. New Study Demonstrates Novel Use of Metabolic Imaging to Locate Sperm in Infertile Men -- Non-Invasive Imaging Procedure May Replace Invasive Techniques such as Testicula
10. Novelty lures rats from cocaine-paired settings, hinting at new treatments for recovering addicts
11. A novel computational model -- how Parkinsons medications affect learning and attention
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2016)... States of America (PRWEB) , ... May 28, 2016 , ... ... SuperCloset knows all too well the day to day issues, struggles and obstacles ... military. The Helping Veterans Grow Project provides active or retired military veteran(s) with ...
(Date:5/28/2016)... ... ... In a part of the city where’s it’s easy to spot the neon lights of ... hoping to attract diners with a taste for real food. , On May 13, ... Cornerstone Grill, an urban casual restaurant focusing on dishes made by hand with wholesome, organic ...
(Date:5/27/2016)... ... May 27, 2016 , ... W.S. Badger Co. Inc ., the maker ... been recognized as one of the best small businesses for new dads by Fatherly, ... nine small businesses providing progressive benefits to new parents on the organization’s 2016 ...
(Date:5/27/2016)... ... 27, 2016 , ... An educational campaign aimed at everyone ... courtesy of awareness-driven celebrities and thought leaders. It also provides insight to the ... leaders such as Bioness. , As patients feel increasingly concerned about the ...
(Date:5/27/2016)... ... May 27, 2016 , ... Aimed at nurses and employees in the ... courtesy of leaders in the nursing and health care industry. It also provides insight ... Abilene Christian University. , As the nursing industry is coming out of one ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... Nev. , May 24, 2016  Diana Russell ... "eats" her organs from the inside out.  This disease ... completely dependent on her children and grandchildren to leave ... her wheelchair, Diana,s family cannot haul the wheelchair.  So ... in the car, and Diana is left to wait ...
(Date:5/24/2016)... LAWRENCEVILLE, N.J. , May 24, 2016 /PRNewswire/ ... an oncology drug development company, today provided an ... Ib dose escalating clinical trial combining GEN-1, the ... for the treatment of newly-diagnosed patients with advanced ... by interval debulking surgery.  GEN-1 is an IL-12 ...
(Date:5/24/2016)... Los innovadores de COMBO[TM], ... introduce catéteres para la intervención de extremidades inferiores ... global especializada en el suministro de soluciones vasculares ... incluyendo productos para tratar la enfermedad arterial periférica. ... los dispositivos de primera entrada de la compañía ...
Breaking Medicine Technology: