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Novel MRI Technique Shows Secondhand Smoke Damages Lungs
Date:11/26/2007

CHICAGO, Nov. 26 /PRNewswire/ -- For the first time, researchers have identified structural damage to the lungs caused by secondhand cigarette smoke.

The results of the study, conducted by researchers at the University of Virginia School of Medicine in Charlottesville and The Children's Hospital of Philadelphia in Pennsylvania, were presented today at the annual meeting of the Radiological Society of North America (RSNA).

"It's long been hypothesized that prolonged exposure to secondhand smoke may cause physical damage to the lungs, but previous methods of analyzing lung changes were not sensitive enough to detect it," said Chengbo Wang, Ph.D., magnetic resonance physicist in the Department of Radiology at The Children's Hospital of Philadelphia.

In recent years, secondhand smoke has emerged as a public health threat. It has been classified as a carcinogen by the Environmental Protection Agency and has been linked to heart disease, lung cancer and a number of respiratory ailments, including asthma and chronic bronchitis. Children are particularly susceptible to the harmful effects of secondhand smoke. According to the American Lung Association, 35 percent of American children live in homes where regular smoking occurs.

Dr. Wang and colleagues used long-time-scale, global helium-3 diffusion magnetic resonance imaging (MRI) to study the lungs of 43 volunteers, including seven current and former smokers and 36 people who had never smoked, 18 of whom had a high level of exposure to secondhand smoke.

Helium-3 diffusion MRI differs from conventional MRI in that the patient inhales a specially prepared helium gas prior to imaging, and the scanner is adjusted to collect images showing this helium gas in tissue. MR measures how far the helium atoms move, or diffuse, inside the lungs during a specific time period -- 1.5 seconds in this study. Using this method, radiologists and physicists can detect changes deep in the small airways and sacs in the lungs, which can break down, become enlarged and develop holes after prolonged exposure to cigarette smoke. Helium-3 diffusion MRI identifies this damage by measuring the increased distance the helium atoms move.

"With this technique, we are able to assess lung structure on a microscopic level," Dr. Wang said.

For the study, measurements were translated into scores called apparent diffusion coefficient (ADC) values for each of the participants. An increased ADC value indicates that the helium atoms were able to travel farther during the measurement time. Fifty-seven percent of the smokers and 33 percent of the nonsmokers with high exposure to secondhand smoke had ADC values greater than 0.024, suggesting that early lung damage was present. In addition, 14 percent of smokers, 67 percent of high-exposure nonsmokers, and 39 percent of low-exposure nonsmokers had ADC values below 0.0185. Relatively low ADC values in adults are a possible indication of a developing respiratory problem, such as chronic bronchitis or asthma.

"These findings suggest that breathing secondhand smoke can injure your lungs," Dr. Wang said. "Since legislation to limit public exposure to secondhand smoke is still being considered in many states, we hope that our work can be used to add momentum to the drive to pass such legislation."

Co-authors are T.A. Altes, M.D., G.W. Miller, Ph.D., E.E. de Lange, M.D., K. Ruppert, Ph.D., J.F. Mata, Ph.D., and G.D. Cates, Ph.D.

AT A GLANCE

-- Helium-3 diffusion MRI shows lung damage caused by secondhand smoke.

-- One-third of nonsmokers with high levels of exposure to secondhand

smoke exhibited structural changes in the lung similar to those in

smokers.

-- Thirty-five percent of U.S. children live in homes where regular

smoking occurs.

Note: Copies of RSNA 2007 news releases and electronic images will be available online at RSNA.org/press07 beginning Monday, Nov. 26.

RSNA is an association of more than 41,000 radiologists, radiation oncologists, medical physicists and related scientists committed to excellence in patient care through education and research. The Society is based in Oak Brook, Ill. (RSNA.org)

Editor's note: The data in these releases may differ from those in the printed abstract and those actually presented at the meeting, as researchers continue to update their data right up until the meeting. To ensure you are using the most up-to-date information, please call the RSNA Newsroom at 1-312-949-3233.


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SOURCE Radiological Society of North America
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