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Novel Diagnostic Marker for Acute Kidney Injury Previewed at Abbott-Sponsored Scientific Workshop
Date:7/29/2008

Data Presented at American Association for Clinical Chemistry (AACC) Meeting Show Urine NGAL Can Potentially Save Lives by Enabling Faster

Detection of Acute Kidney Injury

WASHINGTON, July 29 /PRNewswire-FirstCall/ -- A new diagnostic marker, called urine NGAL, for early detection of acute kidney injury (AKI) in hospitalized patients can distinguish AKI from other forms of kidney dysfunction and save lives by preventing kidney failure, according to research presented today at the American Association for Clinical Chemistry (AACC) annual meeting.

The research was presented by Prasad Devarajan, M.D., director of nephrology and hypertension, Cincinnati Children's Hospital Medical Center, at a scientific workshop hosted by Abbott.

AKI is a common and potentially devastating illness in hospitalized patients. Onset is rapid and can result from trauma, sepsis or administration of medications toxic to the kidneys. AKI can also present following cardiothoracic surgery or as a complication of diabetes and other chronic conditions. AKI quickly reduces the ability of the kidneys to filter waste and leads to renal failure. Many patients with a severe form of AKI face extensive time on dialysis. The mortality rate for patients with AKI ranges up to more than 80 percent in post-operative settings, according to a study reported recently in the Annals of Internal Medicine.

"Unfortunately, the current testing procedure for AKI -- a blood test to measure the ability of the kidneys to filter creatinine into the urine -- is unable to identify the problem in the first 48 hours when time is critical for preventing kidney failure," said Dr. Devarajan. "The incidence of this common complication has risen by 11 percent in recent years, and we need better ways to diagnose and treat the condition and lower the risk of death or needing dialysis," he said.

Devarajan reported today the results of clinical studies conducted for a
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