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Novel DNA vaccine leads to kidney damage prevention in systemic lupus erythematosus models
Date:6/11/2009

del Mercado, Head of the Instituto de Investigacin en Reumatologa y del Sistema Msculo Esqueltico of the Universidad de Guadalajara, Mexico, corresponding author of the study, said: "Some autoantibodies are specific for SLE and are considered to be characteristic of the condition. The mechanisms that regulate the production of these antibodies are poorly understood, however, the results of our study have identified one possible way of influencing the pathway behind kidney damage in SLE."

Studies in human and mouse models of lupus have revealed that the major epitopes of the anti-Sm antibodies are present at specific locations (D1, D2 and B/B) of the Sm antigens. Researchers in this study prepared DNA vaccines of Sm D1, D2, B/B, B/BCOOH, IFN-gamma and IL-10 using direct cloning techniques with pcDNA"3.1D/V5-His-TOPO and purified these using Qiagen Endo-Free Giga Prep Kit. Eight groups of 6 week-old female BALB/c mice (13/group) received intramuscular injections of 100 micrograms of the vaccination preparation at days 2 and 9. At day 16, mice were induced with experimental SLE.

Serum samples were collected at day 0 and then monthly for analysis of autoantibodies and immunoglobulin levels. Serum autoantibodies were tested by immunoprecipitation and ELISA. Proteinuria (excessive protein in the urine) was assessed monthly using Multistix. Kidney pathology and immune complex deposition were examined at 6 months.


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Contact: Rory Berrie
eularpressoffice@uk.cohnwolfe.com
44-078-643-86425
European League Against Rheumatism
Source:Eurekalert

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