Navigation Links
Novel ALS drug slows symptom progression, reduces mortality in phase 2 trial
Date:11/20/2011

Treatment with dexpramipexole a novel drug believed to prevent dysfunction of mitochondria, the subcellular structures that provide most of a cell's energy appears to slow symptom progression in the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Promising results of a phase 2 trial of dexpramipexole are receiving advance online publication in Nature Medicine. Some preliminary results of the study were presented at the 2009 International Symposium on ALS/MND and the 2010 American Academy of Neurology annual meeting.

"Today there are only two FDA-approved drugs used to treat ALS riluzole, which extends life about 10 percent, and Nuedexta, which treats the emotional instability that characterizes ALS and other neurological disorders," says Merit Cudkowicz, MD, director of the Massachusetts General Hospital (MGH) Neurology Clinical Trials Unit and ALS Center, lead author of the study. "We need more therapies to slow, halt and ultimately reverse the course of disease and also therapies to treat the symptoms."

Also known as Lou Gehrig's disease, ALS is a progressive neurodegenerative disease affecting motor neurons in the brain and spinal cord. Death of these nerve cells stops the transmission of neural impulses to muscle fibers, leading to weakness, paralysis and usually death from respiratory failure. Mitochondrial dysfunction is among several factors believed to underlie nerve cell death. Initially developed by Knopp Biosciences of Pittsburgh, dexpramipexole appears to protect neurons from mitochondrial dysfunction.

Several investigators from Knopp, which sponsored the study reported in the current article, collaborated with Cudkowicz and the Northeast ALS Consortium on the trial. Co-founded and co-directed by Cudkowicz, the Northeast ALS Consortium includes over 100 clinical sites throughout North America that work collaboratively on clinical trials and has established the infrastructure necessarily to qui
'/>"/>

Contact: Mike Morrison
mdmorrison@partners.org
617-724-6425
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. NIH grants to Childrens Hospital will advance novel stem cell treatments for blood disorders
2. A novel in vitro model for light-induced wound healing
3. Novel program translates behavioral and social science research into treatments to reduce obesity
4. Reovirus may be a novel approach to prostate cancer treatment
5. Novel stroke treatment passes safety stage of UCI-led clinical trial
6. Novel medical home program for pediatric patients, families cuts ER visits in half
7. MessageSolution First in the Market to Offer All-in-One, Integrated Cloud-Based Archiving for Email, File Systems and SharePoint at Novell BrainShare 2010
8. Novel Parkinson's Treatment Strategy Involves Cell Transplantation
9. Novel Method Eyed for Normalizing Blood Sugar
10. Novel soy germ-based dietary supplement, SE5-OH containing natural S-Equol, examined for safety and influence on hormones in pre- and post-menopausal women
11. Novel nanoparticles prevent radiation damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2015)... (PRWEB) , ... August 30, 2015 , ... Lizzie’s ... a back to school special. The company is currently offering lice head checks for ... addition, the company is offering a 10% discount on their lice treatment products. “With ...
(Date:8/30/2015)... ... August 30, 2015 , ... Nutritional Products International ... the expansion of global cosmeceutical and skin care brands. Mr. Fernandez comes ... last 25 years working in operations, purchasing and management for some of the ...
(Date:8/29/2015)... ... August 30, 2015 , ... Electronic Informed Consent ... – 3:00 p.m. EDT, http://www.fdanews.com/electronicinformedconsent , The simple fact about electronic ... , Clinical trial sites can now use audio, video and interactivity ...
(Date:8/29/2015)... CA (PRWEB) , ... August 29, 2015 , ... Dr. ... a mission. His mission is to increase acceptance of the chiropractic field in ... medications that further debilitate them. Although Chiropractic was made available to the VA ...
(Date:8/29/2015)... ... August 29, 2015 , ... Hamstring strain ... stretching, soft tissue manipulation. Platelet rich plasma injections also have mixed results. ... improve treatment outcomes. This localized treatment seems to address the symptoms and ...
Breaking Medicine News(10 mins):Health News:Lizzie’s Lice Pickers Announces Back to School Head Check Special and Discounted Lice Treatment Products 2Health News:NPI Executive Vice President Leads Cosmeceutical Expansion 2Health News:FDAnews Announces — Electronic Informed Consent for Clinical Trials: Best Practices Webinar, Sept. 15, 2015 2Health News:FDAnews Announces — Electronic Informed Consent for Clinical Trials: Best Practices Webinar, Sept. 15, 2015 3Health News:FDAnews Announces — Electronic Informed Consent for Clinical Trials: Best Practices Webinar, Sept. 15, 2015 4Health News:The Patriot Project brings Chiropractic Care to the Armed Forces and their Families - Rapid Release Technology Joins the Effort to Recruit more Doctors to Pledge 2Health News:NEW APPROACH for Treatment of Recurrent Hamstring Strains and Hamstring Tendinosis is Available for the First Time in NYC 2Health News:NEW APPROACH for Treatment of Recurrent Hamstring Strains and Hamstring Tendinosis is Available for the First Time in NYC 3
... November 16 to benefit Girls on the Run-Chicago, CHICAGO, ... relax, shop, travel and more with all the auction items ... Friday November 16 at the,Chicago Cultural Center. The annual event, ... music from the Underwater,People, cocktails, hors d,oeuvres and plenty of ...
... 9 As part of the Company,s,commitment to ... its support today for the amendment to the ... sold in schools proposed by Senate,Agriculture Committee Chairman ... "Mars US applauds Senators Harkin and Murkowski for ...
... Nov. 9 Give an Hour, a,non-partisan, non-profit organization ... loved ones, announces there are 750,providers nationwide on its ... its network 10 percent, or 40,000,people, of the approximately ... an average fee of $100 an hour, this would ...
... Shire plc (LSE: SHP, NASDAQ: SHPGY, TSX: SHQ), ... a national survey where 60 percent of 121 mothers ... Deficit Hyperactivity Disorder (ADHD) medication stopped working before 6 ... 500 parents of children with ADHD regarding the duration ...
... shed light on why some people suffer from recurrent ... cause characterized by a drop in blood pressure, fainting ... some of these individuals, researchers have found mast cells ... that have a mutated cell surface receptor that disturbs ...
... Globe, Sculpture Promotes Environmental Protection Awareness, NORTH CHICAGO, ... Lake County, Abbott (NYSE: ABT ) has donated ... exhibit in Chicago to the Lake,County Forest Preserves (LCFP) ... in North Chicago, Ill. The "Cool Globes" program, ...
Cached Medicine News:Health News:Chicago's Premier Sports and Fitness Auction is Back! 2Health News:Mars US Supports Harkin/Murkowski Amendment to Update Nutrition Standards for Foods Sold in Schools 2Health News:Non-Profit Calls on Mental Health Professionals to Honor Veterans Day by 'Giving an Hour' of Free Counseling to Returning Veterans 2Health News:Parents survey: Perceptions of the duration of their child's ADHD medication 2Health News:Abnormal immune cells may cause unprovoked anaphylaxis 2Health News:Abnormal immune cells may cause unprovoked anaphylaxis 3Health News:Abbott Donates 'Cool Globe' to Lake County Forest Preserves for Permanent Display at Greenbelt Cultural Center 2Health News:Abbott Donates 'Cool Globe' to Lake County Forest Preserves for Permanent Display at Greenbelt Cultural Center 3
(Date:8/28/2015)... Aug. 28, 2015 ... the addition of the "Investigation Report on ... offering. Developed by Pharmacia & Upjohn ... agonist which effectively reduces intraocular pressure. As the ... (under the trade name of Xalatan) entered ...
(Date:8/28/2015)... DUBLIN , Aug. 28, 2015  Perrigo Company ... that it has completed the acquisition of leading OTC ... at €200 million. The transaction is a clear demonstration ... the Company,s leading European distribution network spanning 36 countries.  ... Joseph C. Papa commented, "We are excited to ...
(Date:8/28/2015)... 28 de agosto de 2015   Royal ... participación en el  Congreso de la ESC de ... recientes y novedosas, entre ellas HeartModel A.I.  , ... personas y la tecnología con los protocolos de ... los tratamientos y permitir atención en el hogar. ...
Breaking Medicine Technology:China Latanoprost Market Investigation Report 2015-2019 2Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 2Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 3Perrigo Completes Acquisition of Leading Portfolio of OTC Brands from GSK 4Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 2Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 3Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 4Philips presenta nuevas soluciones cardiológicas integradas para desarrollar procedimientos menos invasivos 5
... CITY, Calif, Oct. 27 Cardica, Inc. (Nasdaq: ... System and its PAS-Port® Proximal Anastomosis System will be ... the Advances in Robotic and Hybrid Coronary Revascularization conference, ... Robotic Surgery and Saint Joseph,s Hospital in Atlanta, Georgia. ...
... YORK, Oct. 27 Delcath Systems, Inc. (Nasdaq: ... host a conference call to discuss its third quarter ... 2010 at 4:30 p.m. ET.  Eamonn Hobbs, President and ... will host the call. The dial-in number for the ...
Cached Medicine Technology:Cardica's Automated Anastomosis Systems Featured at Advances In Robotic And Hybrid Coronary Revascularization Meeting 2Cardica's Automated Anastomosis Systems Featured at Advances In Robotic And Hybrid Coronary Revascularization Meeting 3Delcath Systems Announces Third Quarter Progress Report Conference Call 2Delcath Systems Announces Third Quarter Progress Report Conference Call 3
The Greenberg retractor and handrest is a versatile, three level system offering efficient space planning, whereby each level has an assigned surgical task....
Io is a surgical digital microscope with head mounted display HMD (Callisto)....
A budget-priced microscope designed for ENT and neuro surgery....
... OME-8000 represents the finest integration ... expertise in optics, digital imaging, ... a surgical microscope. The surgical ... gives the surgeon an unprecedented ...
Medicine Products: