Navigation Links
Novel 4-drug combination proves safe for lung cancer treatment
Date:11/13/2008

CHICAGO - The four drug-combination of carboplatin and paclitaxel, with the targeted therapies bevacizumab (Avastin) and cetuximab (Erbitux), is safe and may improve survival for patients with advanced lung cancer, according to a cooperative group study led by The University of Texas M. D. Anderson Cancer Center.

Presented today on the press program of the 2008 Chicago Multidisciplinary Symposium in Thoracic Oncology, sponsored by ASTRO, ASCO, IASLC and the University of Chicago, the study is the first to investigate in lung cancer a four-drug regimen of two standard chemotherapies and targeted therapies.

The Southwest Oncology Group (SWOG) Phase II study was led by Edward S. Kim, M.D., assistant professor in M. D. Anderson's Department of Thoracic Head and Neck Medical Oncology. Until now, the SWOG standard regimen for lung cancer has been carboplatin, paclitaxel and Erbitux, explained Kim; with the addition of Avastin, this study looked to increase efficacy without compromising safety.

"We could not conduct a study with four chemotherapeutic agents in patients due to toxicity concerns," said Kim, the study's principal investigator. "The rationale behind the study was the finding that Avastin enhances the efficacy of existing therapy, thereby possibly improving the carboplatin-paclitaxel-Erbitux regimen."

Data in lung cancer has also suggested there's a "synergistic effect" of pairing the epidermal growth factor (EGFR) inhibitor compounds with the vascular endothelial growth factor (VEGF) inhibitor, explained Kim.

Interestingly, explained Kim, the SWOG's study came at a crossroads for lung cancer - soon after a study was presented showing the benefits of adding Avastin to standard chemotherapy, and prior to a study showing a modest survival benefit when Erbitux is combined with chemotherapy.

Between August 2006 and September 2007, the large Phase II study enrolled 110 Stage IIIB or IV non-small cell lung c
'/>"/>

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Novel 3-D cell culture model shows selective tumour uptake of nanoparticles
2. Novel virus detection identifies new viruses in study of respiratory infections and asthma attacks
3. Researchers uncover novel mechanism that balances the sizes of functional areas in the brain
4. Novel Cooling Therapy May Have Aided Injured Football Player
5. ECLIPSE data on effects of Otsukas investigational novel treatment, Tolvaptan
6. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
7. GrantAdler Shipping Novel Implantable Vascular Access Port
8. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
9. Novel strategy under study for aggressive leukemia
10. ISTO Technologies Receives 510(k) Clearance for a Novel Bone Graft Substitute and Bone Graft Extender
11. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... 29, 2014 PeopleKeys today announced that ... teach students how to train and certify others in ... Behavioral Consultant Trainer , will be taught by PeopleKeys ... Training John Schindell as a live Tele-course over the ... The Certified Behavioral Consultant Trainer course will use a ...
(Date:7/29/2014)... In today’s world, a good night’s sleep has ... sleep apnea (a medical problem where the airway collapses during ... of the rest they need to face their daily challenges. ... 20 million people in the United States alone have sleep ... and of those treated, many cannot tolerate their prescribed medical ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 In its ... offers treatment programs and believes that having family close ... big difference in whether or not the process is ... myths. , “It’s difficult to estimate just how damaging ... Rehabilitation’s CEO Per Wickstrom . “Not only do ...
(Date:7/29/2014)... 2014 Nuanced Media, a leading digital ... HIPAA (Health Insurance Portability and Accountability Act) certified firm. ... storage and transfer of Personal Health Information (PHI). ... Nuanced Media can effectively serve their medical industry clients. ... to offer medical industry specific products such as ...
(Date:7/29/2014)... brides want their bridal dresses and bridal parties to ... sure to provide designs of wedding gowns and bridesmaids ... has recently announced its new collection of gorgeous lace ... come with big savings, up to 61% off. , ... working in the garment industry for several years; they ...
Breaking Medicine News(10 mins):Health News:PeopleKeys Announces New Certified Behavioral Consultant Trainer Course 2Health News:PeopleKeys Announces New Certified Behavioral Consultant Trainer Course 3Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:Latest Best Drug Rehabilitation Blog Post Busts 4 Big Addiction Myths 2Health News:Latest Best Drug Rehabilitation Blog Post Busts 4 Big Addiction Myths 3Health News:Nuanced Media Web Design Agency Now Hipaa Certified 2Health News:LunaDress’ Summer Sale Has Arrived: All Its Gorgeous Lace Wedding Dresses are Affordable Now 2
... Epidemiologists have long warned that, in addition to causing ... person at greater risk for colon cancer. Now, researchers ... explain why. The findings, "Epigenetic Differences in Normal ... Pathways," were published in the March issue of the ...
... HIV-positive patient, one of her first questions is whether he ... response is about dead relatives or friends. "We talk about ... experience will be very different," said the infectious-disease specialist at ... "Yes it,s the same virus and could have the same ...
... Researchers from Boston University School of Medicine (BUSM) and ... breast pain who receive imaging (mammograms, MRIs or ultrasounds) ... testing, but do not gain benefit from these additional ... of General Internal Medicine. Breast pain is ...
... -- Exposure to cocaine, tobacco or marijuana before birth ... tests, according to a new study. Prenatal alcohol ... fetal alcohol syndrome, was associated with lower scores at ... researchers found. The negative associations between intrauterine alcohol ...
... Reporter , TUESDAY, March 6 (HealthDay News) -- New research ... longevity in humans by showing that genetically modified mice live ... a few differences between mice and humans, especially in regard ... genetic tweak, so there,s no way to know if the ...
... -- When faced with stressful situations, older adults who sleep ... a new study finds. The marker, called interleukin-6 (IL-6), ... as cardiovascular disease, diabetes and psychiatric problems. "Our study ... sleep and what poor sleep may be doing to our ...
Cached Medicine News:Health News:Study shows how high-fat diets increase colon cancer risk 2Health News:Federal grant enables HIV testing, treatment in the Augusta area 2Health News:Federal grant enables HIV testing, treatment in the Augusta area 3Health News:Research finds little benefit of breast imaging tests for women with breast pain 2Health News:Fetal Cocaine Exposure May Not Affect Kids' Academics: Study 2Health News:Genetic Tweak Helps Mice Avoid Cancer, Obesity: Study 2Health News:Poor Sleep May Impact Stress Response in Older Adults 2
(Date:7/29/2014)... , July 29, 2014 , ... /Oxymorphone clinical development program has commenced , ... during Q4 2014 , TPM®/Oxymorphone ... States in 1H 2015 Australian drug delivery ... its opioid transdermal patch programs after its recent announcement of a ...
(Date:7/29/2014)... July 29, 2014   ... that it has taken an exclusive worldwide licence to ... a Durham University spin-out company. ... pay an upfront fee, development and commercial milestone payments, ... also taken an option for additional exclusive licences to ...
(Date:7/28/2014)... Calif. , July 28, 2014 Pharmacyclics, Inc. ... it will hold a conference call and audio webcast to ... the NASDAQ Market closes on Thursday, July 31, 2014 at ... details: Date: July 31, 2014 Time: ... Toll-free: (877) 303-7908 International: (678) 373-0875 A webcast ...
Breaking Medicine Technology:Phosphagenics Provides Update on Opioid Patch Program 2Phosphagenics Provides Update on Opioid Patch Program 3Phosphagenics Provides Update on Opioid Patch Program 4Phosphagenics Provides Update on Opioid Patch Program 5Phosphagenics Provides Update on Opioid Patch Program 6Glide Pharma Takes Exclusive Worldwide Rights to Novel Diagnostic Technology for Prostate Cancer 2Glide Pharma Takes Exclusive Worldwide Rights to Novel Diagnostic Technology for Prostate Cancer 3Pharmacyclics Announces Date of Conference call to discuss Financial Results for Second Quarter of 2014 2
... Watson Pharmaceuticals, Inc. (NYSE: WPI ), ... Wilkinson , Watson,s Executive Vice President, Global Brands, will provide ... Investment Research Global Healthcare Conference on Wednesday, May 26, ... presentation will be webcast live and can be accessed on ...
... Prometheus Laboratories Inc., a specialty pharmaceutical and diagnostic company, announced a ... infliximab, a biologic therapy that has been used to treat more ... rheumatoid arthritis, Crohn,s disease and ulcerative colitis. , ... Human anti-chimeric antibody (HACA) levels have ...
Cached Medicine Technology:Watson to Present at the 2010 Citi Investment Research Global Healthcare Conference 2Prometheus Announces New Method for Real-Time Monitoring of Patients Treated With Biologic Therapy 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: