Navigation Links
Novel 3-D cell culture model shows selective tumour uptake of nanoparticles
Date:9/2/2007

A nanoparticle drug delivery system designed for brain tumour therapy has shown promising tumour cell selectivity in a novel cell culture model devised by scientists at The University of Nottingham. The project, conducted jointly by the Schools of Pharmacy, Biomedical Sciences and Human Development, will be featured in the September issue of the Experimental Biology and Medicine.

Therapy for brain cancers is particularly difficult for a number of reasons, including getting sufficient drug to the tumour and selectivity of drug action. Dr Martin Garnett, Associate Professor of drug delivery at the School of Pharmacy said: We are working on a number of new therapeutic approaches using nanoparticle drug delivery systems. However, understanding and developing these systems requires suitable models for their evaluation.

The nanoparticles used in this study were prepared from a novel biodegradable polymer poly (glycerol adipate). The polymer has been further modified to enhance incorporation of drugs and make the nanoparticles more effective.

Dr Terence Parker, Associate Professor in the School of Biomedical Sciences explained: The interaction of tumour cells with brain cells varies between different tumours and different locations within the brain. Using 3-dimensional culture models is therefore important in ensuring that the behaviour of cells in culture is similar to that seen in real life.

The work was mainly carried out by graduate student Weina Meng who formulated the fluorescently labelled nanoparticles and studied them in a variety of tumour and brain cell cultures. Her early studies showed faster uptake of nanoparticles into tumour cell cultures than normal brain cell cultures grown separately. This selectivity was only seen in 3-dimensional cultures and was the driving force to develop a more complex and representative model.

Tumour cell aggregates have been used as cell culture models of cancer cells for man
'/>"/>

Contact: Dr Martin Garnett
44-011-595-15045
University of Nottingham
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Novel "CYCLOSPORINE CAPSULE FORMULATION" to be launched
2. Novel antibiotic dressing developed for improved wound healing
3. A novel augmentation
4. Novel biopsy technique for prostate cancer
5. Novel computer model for breast cancer
6. Novel research on liver cancer
7. Novel way to fight cancer
8. Novel test for bowel cancer
9. Novel Anti-Neutrophilic Effect produced by Salmeterol in mild asthma patients
10. Novel Therapy for Chronic Problem
11. Gene enchances radiation therapy - A novel approach to fight cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... Australia (PRWEB) November 22, 2014 ... the declined slightly in 2009-10, due to a ... Product Manufacturing industry products amid the global ... the growing strength of Australian dairy manufacturers on ... for dairy products outweighed supply growth, primarily due ...
(Date:11/22/2014)... York (PRWEB) November 22, 2014 Lipitor ... behalf of patients who allegedly developed Type 2 diabetes ... the federal multidistrict litigation now underway in U.S. District ... According to court documents, the litigation will convene its ... The Court has directed Lead Counsel for Plaintiffs and ...
(Date:11/22/2014)... (PRWEB) November 22, 2014 Recently, UWDress.com ... wedding guest dresses . In addition, the company ... products. , As a leading online supplier of ... of beautiful outfits. The unusual best wedding guest gowns ... Besides the amazing designs, this new selection is famous ...
(Date:11/22/2014)... (PRWEB) November 22, 2014 Sandbridge ... equity investments in the consumer brand sector, acquired ... investment will be used to help fund BackJoy’s ... pipeline rollout, particularly its proprietary apparel and footwear ... join BackJoy’s Board of Directors. , BackJoy is ...
(Date:11/22/2014)... “Greenfield Naturals” was featured on NewsWatch as part ... the latest and coolest technology products available to consumers. ... conducted the product review and shared with viewers how ... , From pollution to hazardous substances in water, harmful ... to remove these chemicals, especially in water. , A ...
Breaking Medicine News(10 mins):Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 4Health News:Lipitor Lawsuit Conference Scheduled for December, Bernstein Liebhard LLP Reports 2Health News:Lipitor Lawsuit Conference Scheduled for December, Bernstein Liebhard LLP Reports 3Health News:Best Wedding Guest dresses Introduced by UWDress.com 2Health News:Sandbridge Capital Acquires a Minority Stake in BackJoy 2Health News:Sandbridge Capital Acquires a Minority Stake in BackJoy 3Health News:An Easy Home Solution to Get Better Tasting Water was Featured on NewsWatch Television on October 30, 2014 2
... , , WASHINGTON, ... today at the Centers for Disease Control and Prevention (CDC) Weight ... being recognized for their work in advancing policies and environmental strategies ... rising rates of obesity in adults, particularly those from certain racial ...
... ... chain costs and improve operations , ... Dallas, TX (Vocus) July 29, 2009 -- Broadlane, the leading ... Inc. (AHMC) in Alhambra, California has renewed its exclusive supply chain relationship with Broadlane ...
... Boston Scientific Corporation (NYSE: BSX ) today announced that ... Bruce L. Byrnes as Directors. , , ... at the Duke University School of Law, where she served as ... major strategic expansion. During Bartlett,s tenure as Dean, the Law ...
... HAIKOU CITY, China, July 29 /PRNewswire-Asia-FirstCall/ -- China Pharma,Holdings, ... and markets specialty pharmaceutical products in China, today,announced that ... on,Wednesday, August 12, 2009, before the market opens. , ... conference call at 8:00 am ET on August 12, ...
... a day cut risk in half in study of Finnish ... consumption associated with moderate- to high-intensity exercise appears to reduce ... The Finnish study included 2,560 men, aged 42 to 61, ... of the men had a history of cancer, according to ...
... , , , , ... Holy Family Memorial Health Network (HFM) has achieved Stage 6 on ... Society) Electronic Medical Record (EMR) Adoption Model scale. The achievement ... on improving patient-care safety and quality. , , ...
Cached Medicine News:Health News:CDC Recognizes Innovative Obesity Prevention and Control Initiatives With Weight of the Nation Awards 2Health News:CDC Recognizes Innovative Obesity Prevention and Control Initiatives With Weight of the Nation Awards 3Health News:CDC Recognizes Innovative Obesity Prevention and Control Initiatives With Weight of the Nation Awards 4Health News:AHMC Inc. & AHMC Healthcare Inc. Continue to Focus on Cost-Management 2Health News:AHMC Inc. & AHMC Healthcare Inc. Continue to Focus on Cost-Management 3Health News:Boston Scientific Announces Election of Katharine Bartlett and Bruce Byrnes to Its Board of Directors 2Health News:Boston Scientific Announces Election of Katharine Bartlett and Bruce Byrnes to Its Board of Directors 3Health News:China Pharma Holdings, Inc. to Report Second Quarter 2009 Financial Results on August 12, 2009 2Health News:Holy Family Memorial Health Network Bolsters Patient Care Quality and Safety in Achieving Stage 6 on HIMSS Analytics EMR Adoption Model(SM) Scale 2Health News:Holy Family Memorial Health Network Bolsters Patient Care Quality and Safety in Achieving Stage 6 on HIMSS Analytics EMR Adoption Model(SM) Scale 3Health News:Holy Family Memorial Health Network Bolsters Patient Care Quality and Safety in Achieving Stage 6 on HIMSS Analytics EMR Adoption Model(SM) Scale 4Health News:Holy Family Memorial Health Network Bolsters Patient Care Quality and Safety in Achieving Stage 6 on HIMSS Analytics EMR Adoption Model(SM) Scale 5
(Date:11/22/2014)... , Nov. 21, 2014 MEDITE Group acquired by ... months and the 3 rd quarter sales ended September ... was $448,000 for the nine months ended September 2014 and ... though our 3 rd quarter is usually a seasonable ... from July into September for many countries worldwide, we are ...
(Date:11/21/2014)... COLLEGE PARK, Md. , Nov. 21, 2014 /PRNewswire-USNewswire/ ... Engineering today will host the ceremonial groundbreaking of the ... Maryland, College Park. The new building will cultivate transformative ... human health.  Taking place at 10:00 a.m. ... building in the Paint Branch Parking Lot, adjacent to ...
(Date:11/21/2014)... MARCOS, Texas , Nov. 21, 2014  World ... hemp containing low THC, announces they are now offering ... comparable to Charlotte,s Web type strains grown in medical ... from other neurological disorders, such as Parkinson,s, MS, and ... for US laws to pass, because imported CBD Oil ...
Breaking Medicine Technology:CytoCore Inc. / MEDITE Cancer Diagnostics, Inc. Reports Record YTD and 3rd Quarter Sales 2CytoCore Inc. / MEDITE Cancer Diagnostics, Inc. Reports Record YTD and 3rd Quarter Sales 3University of Maryland Breaks Ground for A. James Clark Hall 2University of Maryland Breaks Ground for A. James Clark Hall 3University of Maryland Breaks Ground for A. James Clark Hall 4New CBD Oil From Industrial Hemp is Comparable to Charlotte's Web, Legal In All 50 States 2New CBD Oil From Industrial Hemp is Comparable to Charlotte's Web, Legal In All 50 States 3
... Inc. (OTC BB: NSPR) ("Inspire" or the "Company"), the ... announced that Mr. Ofir Paz, InspireMD,s co-founder and chief ... will participate in the Benchmark Company, LLC One-on-One Investor ... Hotel, 424 East Wisconsin Ave., Milwaukee, Wis. The conference ...
... Axcan Intermediate Holdings Inc. announces that it ... the recently completed combination of two specialty pharma companies ... also has a new corporate logo and website (please ... "Our new name, Aptalis, is intended to capture the ...
Cached Medicine Technology:InspireMD to Participate in Benchmark Company, LLC 2011 One-On-One Investor Conference 2InspireMD to Participate in Benchmark Company, LLC 2011 One-On-One Investor Conference 3The Newly Combined Axcan and Eurand Announce Name Change to Aptalis 2The Newly Combined Axcan and Eurand Announce Name Change to Aptalis 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: