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Novel, noninvasive measurement a strong predictor for heart failure in general population
Date:11/14/2011

tery pressure obtained at baseline from 5,958 participants in the Multi-Ethnic Study of Atherosclerosis (MESA) and assessed the relationship between the magnitude of the reflected wave at baseline and incident cardiovascular events (CVE) and congestive heart failure (CHF). All patients in the MESA cohort had no known cardiovascular disease at baseline.

During median 6.46 years of follow-up in the current study, the researchers found that even just a 10 percent increase in wave reflection magnitude was predictive of a higher risk of combined cardiovascular events, hard cardiovascular events, and was strongly predictive of incident heart failure. This measure was a stronger predictor of CHF risk than hypertension and other established modifiable risk factors, as measured by established medical standards and population-based risks. This suggests that wave reflections are important determinants of heart failure risk.

"Although more experimental studies and clinical trials should be pursued to confirm a causal role, these findings interpreted in the context of available data, identify increased wave reflections as a new potential mechanistic risk factor for heart failure in the general population," said Dr. Chirinos. "We hope that this line of research has the potential to lead to therapeutic approaches for prevention of heart failure."

MESA is a longitudinal study of the characteristics of subclinical cardiovascular disease (disease detected non-invasively before it has produced clinical signs and symptoms) and risk factors that predict progression from subclinical to clinically cardiovascular disease, in a diverse population-based sample. Participants in MESA come from diverse race and ethnic groups, including African Americans, Latinos, Asians, and Caucasians. MESA is sponsored by the National Heart, Lung, and Blood Institute of the National Institutes of Health.


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Contact: Jessica Mikulski
jessica.mikulski@uphs.upenn.edu
215-796-4829
University of Pennsylvania School of Medicine
Source:Eurekalert

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