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Novel, noninvasive measurement a strong predictor for heart failure in general population
Date:11/14/2011

Orlando A new study from researchers at the Perelman School of Medicine at the University of Pennsylvania and collaborators at various institutions, presented at the 2011 American Heart Association Scientific Sessions, shows that a novel, non-invasive measurement of arterial wave reflections may be able to predict who is most at risk for heart failure. The authors presented data from an ancillary study of the Multi-Ethnic Study of Atherosclerosis (MESA).

When the heart contracts it generates a pulse or energy wave that travels through the arteries. This wave gets reflected in parts of the arterial tree and returns to the heart while it is ejecting blood, increasing the heart's workload. Increased wave reflections can lead to increased pressure on the heart and have been shown to be independent predictors of cardiovascular morbidity and mortality in populations with established heart disease or advanced kidney disease, but their association with adverse outcomes in the general population has remained unclear. Furthermore, the specific association between increased wave reflections and heart failure had not been shown before.

"Over five million people in the U.S. alone have heart failure, and it results in approximately 300,000 deaths each year. It's critical that we work to discover novel ways to identify patients most at risk," said Julio A. Chirinos, MD, assistant professor of Medicine at Penn and the study's lead author. "We show for the first time in a large general population that people with prominent arterial wave reflections are at greater risk for developing heart failure in the future."

In the current study, Dr. Chirinos and collaborators measured arterial wave reflections with a simple, non-invasive procedure known as arterial tonometry. Arterial tonometry is a technique for blood-pressure measurement in which an array of pressure sensors is pressed against the skin over an artery. The researchers analyzed the radial ar
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Contact: Jessica Mikulski
jessica.mikulski@uphs.upenn.edu
215-796-4829
University of Pennsylvania School of Medicine
Source:Eurekalert

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