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Nottingham expertise in major European drug discovery partnership
Date:1/24/2013

Scientists from Nottingham are part of a major European-wide project aimed at developing the next generation of medicines that are more effective and longer lasting.

The academics from The University of Nottingham are using high-tech laser technology to study in real-time how drug molecules 'stick' to receptors or proteins on the surface of cells in our body in an effort to learn more about how drugs work.

Learning how drugs interact with the cells in our body could lead to further clues on how to design drugs for chronic and life threatening illnesses, such as cancer and asthma, which are better at treating patients and don't have to be taken as regularly as current therapies.

Professor Steve Hill, in the University's School of Biomedical Sciences, is leading the Nottingham side of the project. He said: "The ultimate aim here is to find new ways of interacting with some of those receptors which might form better drugs.

"Nottingham's expertise is in using clever ways to visualise in real-time the speed at which drugs bind and unbind to proteins in the body and to learn about how adding other drugs at the same time may improve or inhibit that.

"The goal will be to develop new medicines that patients don't have to remember to take twice or three times a day or with a meal just one dose a day would be enough."

Bench to bedside

Nottingham is part of a new 18m consortium supported by Europe's Innovative Medicines Initiative (IMI) and major pharmaceutical companies aimed at tackling the development of new drugs. During the course of the five-year project around 500,000 of that funding will come to Nottingham.

Almost 90 per cent of experimental drugs that are tested through expensive clinical trials fail at the final hurdle because they don't work as well as they should. In fact, only one in around 15,000 potential new drugs will make it to market a process that can take almost 15 years fr
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Contact: Emma Thorne
emma.thorne@nottingham.ac.uk
44-011-595-15793
University of Nottingham
Source:Eurekalert

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