Navigation Links
Notre Dame and Harper researchers developing novel method to test for HPV and oral cancers
Date:6/24/2013

Research being carried out at the University of Notre Dame and its affiliated Harper Cancer Research Institute (HCRI) may lead to the development of a rapid, cost-effective means of screening for oral cancers and the human papillomavirus.

M. Sharon Stack, Ann F. and Elizabeth Riley director of the HCRI and professor of chemistry and biochemistry, points out that oral cancers are a significant global health problem. Although tobacco and alcohol awareness have helped decrease the overall incidence of oral cancers, HPV positive cancers, especially oropharynx cancers, have risen significantly.

Stack and Hsueh-Chia Chang, Bayer Professor of Engineering and director of Notre Dame's Center for Microfluidics and Medical Diagnostics, are attempting to prescreen for oral cancer and HPV by examining the micro-RNAs of tumor cells. They are working on developing a microfluidic sensor to help detect the presence of tumor cells.

The researchers point out that to be effective, the screening tests need to be done regularly, for example at a dentist's office during teeth cleaning. Rinsing with a mouthwash at a dentist's office can produce up to 10,000 cells that can be tested. In order to be feasible for a dentist's office, the screening process must be low cost, rapid and patient-friendly.

Chang's research group has developed a microfluidic membrane sensor that can be used for this type of rapid screening. Although he points out that his sensor is not as accurate as optical sensors like real-time polymerase chain reaction (PCR), it is much cheaper ($1 versus $45 per test) and is rapid and can be used by personnel in a dentist's office. It also will allow the quantification of a panel of micro-RNAs.

The researchers believe that such a rapid and low-cost device would help to better reach high-risk patients prior to development of last-stage disease.


'/>"/>

Contact: Sharon Stack
Sharon.Stack.11@nd.edu
574-631-2518
University of Notre Dame
Source:Eurekalert

Page: 1

Related medicine news :

1. Nanoparticles engineered at Notre Dame promise to improve blood cancer treatment
2. Notre Dame researchers paper examines the biology of tumor-derived microvesicles
3. Notre Dame researchers scoring a win-win with novel set of concussion diagnostic tools
4. New Notre Dame paper offers insights into how cancer cells avoid cell death
5. Maricopa Community Colleges Provost Dr. Maria Harper-Marinick Named Among Arizona's Most Influential Executives
6. New from HarperOne Publishers: Art Smith's Healthy Comfort - How America's Favorite Celebrity Chef Got It Together, Lost Weight, and Reclaimed His Health!
7. Harper Government and Genome Canada launch new program
8. NIH awards $20 million over 5 years to train next generation of global health researchers
9. Researchers develop a new cell and animal model of inflammatory breast cancer
10. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
11. Researchers Find Gene Mutations That May Be a Key to Autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... Michael and ... Dana Farber Cancer Institute. For Betsy, the clinical trial has been life-saving as ... has not worsened. , Betsy Brauser was diagnosed with ovarian cancer in 2009. ...
(Date:1/20/2017)... New York, NY (PRWEB) , ... January 20, ... ... drinks – VW+ 001 and its sugar-free alternative VW+ 002. The drinks have ... the body with optimal conditions to perform during your workout. , After a ...
(Date:1/20/2017)... ... January 20, 2017 , ... “The Angel”: a heartwarming and earnest ... for each of his children. “The Angel” is the creation of published author, Marjorie ... York City, and impassioned writer. , When asked of her new book, Marjorie says, ...
(Date:1/20/2017)... ... ... fine examination of how God handles sin, including how to let go of lingering guilt ... over ten long years has been waiting to release this powerful insight about forgiveness that ... serving the Lord for over twenty years, and he has been preaching and teaching the ...
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... “Christmas in ... creation of published author, Sara Seymour, who lives in Lafayette, Indiana where she works ... sips on iced coffees and writes. , Published by Christian Faith Publishing, Sara Seymour’s ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... James Gilbart , ... 2016;12(Suppl 2):3-8; http://www.touchoncology.com/articles/optimising-clinical-outcomes-gastrointestinal-cancers-through-inhibiting-angiogenesis-and ... ... recently in a supplement to European Oncology & ... article by James Gilbart and ...
(Date:1/19/2017)... -- ViewRay, Inc. (Nasdaq: VRAY) announced today that the German ... Germany , has purchased a MRIdian ... Clinic Heidelberg as part of its initiative for MRI-based ... be headed by Medical Director and Professor Jürgen Debus, ... German Cancer Research Center (DKFZ), the Heidelberg Heavy Ion ...
(Date:1/19/2017)... PALO ALTO, Calif. , Jan. 19, 2017 /PRNewswire/ ... scientific research, is excited to announce that the ... Project: Cancer Biology  (RP:CB) have been published in ... science, this project represents the first practical evaluation ... that result in reproducible studies. Unlike other assessments ...
Breaking Medicine Technology: