Navigation Links
Notre Dame and Harper researchers developing novel method to test for HPV and oral cancers
Date:6/24/2013

Research being carried out at the University of Notre Dame and its affiliated Harper Cancer Research Institute (HCRI) may lead to the development of a rapid, cost-effective means of screening for oral cancers and the human papillomavirus.

M. Sharon Stack, Ann F. and Elizabeth Riley director of the HCRI and professor of chemistry and biochemistry, points out that oral cancers are a significant global health problem. Although tobacco and alcohol awareness have helped decrease the overall incidence of oral cancers, HPV positive cancers, especially oropharynx cancers, have risen significantly.

Stack and Hsueh-Chia Chang, Bayer Professor of Engineering and director of Notre Dame's Center for Microfluidics and Medical Diagnostics, are attempting to prescreen for oral cancer and HPV by examining the micro-RNAs of tumor cells. They are working on developing a microfluidic sensor to help detect the presence of tumor cells.

The researchers point out that to be effective, the screening tests need to be done regularly, for example at a dentist's office during teeth cleaning. Rinsing with a mouthwash at a dentist's office can produce up to 10,000 cells that can be tested. In order to be feasible for a dentist's office, the screening process must be low cost, rapid and patient-friendly.

Chang's research group has developed a microfluidic membrane sensor that can be used for this type of rapid screening. Although he points out that his sensor is not as accurate as optical sensors like real-time polymerase chain reaction (PCR), it is much cheaper ($1 versus $45 per test) and is rapid and can be used by personnel in a dentist's office. It also will allow the quantification of a panel of micro-RNAs.

The researchers believe that such a rapid and low-cost device would help to better reach high-risk patients prior to development of last-stage disease.


'/>"/>

Contact: Sharon Stack
Sharon.Stack.11@nd.edu
574-631-2518
University of Notre Dame
Source:Eurekalert

Page: 1

Related medicine news :

1. Nanoparticles engineered at Notre Dame promise to improve blood cancer treatment
2. Notre Dame researchers paper examines the biology of tumor-derived microvesicles
3. Notre Dame researchers scoring a win-win with novel set of concussion diagnostic tools
4. New Notre Dame paper offers insights into how cancer cells avoid cell death
5. Maricopa Community Colleges Provost Dr. Maria Harper-Marinick Named Among Arizona's Most Influential Executives
6. New from HarperOne Publishers: Art Smith's Healthy Comfort - How America's Favorite Celebrity Chef Got It Together, Lost Weight, and Reclaimed His Health!
7. Harper Government and Genome Canada launch new program
8. NIH awards $20 million over 5 years to train next generation of global health researchers
9. Researchers develop a new cell and animal model of inflammatory breast cancer
10. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
11. Researchers Find Gene Mutations That May Be a Key to Autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... , ... “Vintage and Harvest A Cultivation of Christian Love” is the creation ... North Carolina with his wife, Anna Marie. He and his wife are the proud ... also the author of “Shadow and Substance.” , “Love, the agape kind, is seen ...
(Date:3/23/2017)... ... 2017 , ... In 2016 the World Health Organization declared the Zika virus ... Zika-related cases in the Americas within the next year. Lyme disease is one of ... skyrocketing to an estimated 329,000. Yet, Zika, Lyme and other insect borne illnesses are ...
(Date:3/23/2017)... ... March 23, 2017 , ... Demonstrating ... communities, 16 more public health departments have been awarded national accreditation through the ... million people into the expanding network of communities across the nation whose health ...
(Date:3/23/2017)... ... March 23, 2017 , ... The IoT (Internet of Things) is ... making a huge impact on businesses and individual consumers alike. Laboratories can maximize ... have a value anywhere from $4 trillion to $11 trillion dollars by the year ...
(Date:3/23/2017)... , ... March 23, 2017 ... ... financial services firm serving the families and businesses of the Norwalk and ... program. Northern Ohio Recovery Center (N.O.R.A.) is a nonprofit, community-based substance abuse ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... March 24, 2017 ShangPharma, a ... and cost-effective drug development and discovery services, ... biotechnology industry, announced today the intent for ... will be consolidating the Contract Research Organizations ... Shanghai ChemPartner. These entities include ChemPartner Shanghai, ...
(Date:3/24/2017)... India , March 24, 2017 A ... market has been growing rapidly as the global sales of Adcetris ... the growth in the antibody drug conjugates market is driven by ... of cancer and wider therapeutic window offered by ADCs. ... Browse 3 Tables and 94 ...
(Date:3/24/2017)... , March 24, 2017  Eli Lilly and ... plans to invest $850 million in its U.S. ... across its U.S. enterprise, including research laboratories, manufacturing ... are being driven by demand for Lilly products, ... medicines in development targeting cancer, pain, diabetes and ...
Breaking Medicine Technology: