Navigation Links
Noted Vertebroplasty Expert Cites Concerns About Recently Published Study
Date:8/11/2009

Dr. Mubin Syed evaluates findings; calls for additional research

DAYTON, Ohio, Aug. 11 /PRNewswire/ -- A new study by Mayo Clinic researchers has given rise to more questions than answers about the effectiveness of vertebroplasty to treat osteoporotic spinal fractures.

Vertebroplasty is a widely used procedure in which medical cement is injected into vertebrae to relieve pain and improve mobility in patients who have osteoporotic fractures. This study, funded by the National Institutes of Health, was the first of its kind, using a double-blinded research model to examine the impact of vertebroplasty. It was published last week in The New England Journal of Medicine to mixed reviews by the medical community.

"This was an extremely interesting study, but the results are far from conclusive due to several weaknesses in the method used. Additional research is definitely indicated," said Dr. Mubin I. Syed, a neuroradiologist and diagnostic, interventional and vascular radiologist.

One major issue cited by Dr. Syed was the small size of the study group. To demonstrate statistical differences between groups requires that the research team enroll enough patients for the statistics to have meaning. The original group size for the Mayo Clinic study was to be 250 patients. Due to difficulties in recruiting participants, the final group size was reduced to 131 people, nearly half of the original design.

"This is important," explained Dr. Syed, "because the trends in the data show that if the study had enough patients, the group receiving vertebroplasty could have demonstrated a clinically meaningful improvement in pain. It is therefore surprising that a study that was showing a trend toward statistical significance was terminated early with only half the number of patients recruited. A huge doubt now remains as to whether a study with the original intended group size would have yielded a different outcome."

Additionally, selection bias could have also played a large part in the study's results. "Only 131 out of 431 (30.4 percent) eligible patients elected to participate, increasing the potential for selection bias," noted Dr. Syed.

A third issue was the crossover rate for patients who received the control or "placebo" procedure. Patients in the trial were able to "cross over" and get the other treatment after one month.

"Even though they had no confirmation of which treatment they received, nearly four times as many patients or 43 percent who had the control treatment crossed over to have vertebroplasty performed, compared to 12 percent of vertebroplasty patients who switched," said Dr. Syed.

The final issue to consider is that the control procedure included injecting 0.25 percent of bupivicaine into the periosteum of the pedicles. "The problem," explained Dr. Syed, "is that this resembles a medial branch block for the treatment of facet-related pain. The duration of relief following medial branch block is variable, but may last for several weeks."

He added that many patients with compression fractures have concurrent facet-related pain due to stress on the facet joint as a result of the fracture.

"I applaud Dr. Kallmes for his work. His study is very interesting, but I don't think it's conclusive. Additional research is needed to truly assess the efficacy of vertebroplasty," said Dr. Syed.

Dr. Syed is on staff at Good Samaritan Hospital and Dayton Heart Hospital in Dayton. He is also a founding partner of Dayton Interventional Radiology. In addition, Dr. Syed has participated in clinical trials and published several papers on vertebroplasty.


'/>"/>
SOURCE Dr. Mubin I. Syed
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Signs of Depression Noted in Second Graders
2. UPDATE: Swine Flu Spread Will Trigger Difficult Legal Questions for Employers Says Noted Pillsbury Attorney
3. Swine Flu Plans Triggering Difficult Legal Questions, Says Noted Pillsbury Attorney
4. Kouros Azar, M.D. (doctorazar.com), Noted Plastic and Reconstructive Surgeon, Offers Top 10 Tips to Patients to Help Celebrate National Patient Safety Awareness Week
5. Noted State Government Medical Director Dr. Stephen Saunders To Join APS Healthcare
6. Three Noted Women of Valor to be Honored at Los Angeles Jewish Home Gala Dinner
7. 4th annual Templeton-Cambridge fellowships awarded to 10 noted journalists
8. Noted Litigator Peter Diedrich Joins Musick Peeler & Garrett LLP
9. 39 Noted Performing Artists Urge Congress to Fix Flaws in Presidents Global AIDS Plan
10. Los Angeles Jewish Home Support Group Continues High-Profile Speaker Program With Noted Legal Scholar and Expert Laurie L. Levenson
11. Arizona Pain Specialists Contend Recent Vertebroplasty Studies are Misleading: Studies Actually Show it is Effective at Reducing Pain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/28/2017)... ... June 28, 2017 , ... Eating disorders have the highest mortality rate of ... one person dies as a direct result from an eating disorder in the U.S. ... providers. The iaedp Foundation meets this challenge by offering what has become the leading ...
(Date:6/28/2017)... ... June 28, 2017 , ... Park Systems , ... Luncheon for all SEMICONWest attendees and Park customers on July 11, 2017 ... from Dr. Sang-il Park, Chairman & CEO of Park Systems, and Prof. Krishna ...
(Date:6/28/2017)... (PRWEB) , ... June 28, 2017 , ... ... assistance and financial consultations to communities in northern Virginia and DC, is announcing ... help provide for patients with Alzheimer’s and other disorders that lead to memory ...
(Date:6/27/2017)... PA and London UK (PRWEB) , ... June 27, 2017 , ... ... applying to a clinical study is whether they can trust the sponsor to pay ... it is vital that sponsors and CROs establish payment strategies that encourage sites to ...
(Date:6/27/2017)... ... 27, 2017 , ... Building on the success of the ... sixth state to pass legislation which ensures that children can possess and use ... the states of Alabama, Arizona, Florida, Utah and Washington who have also approved ...
Breaking Medicine News(10 mins):
(Date:6/13/2017)... Ind. , June 13, 2017 Zimmer Biomet ... musculoskeletal healthcare, today announced that the U.S. Food and Drug ... dated June 3, 2015 relating to its Zhejiang, ... "The successful clearance of the ... manufacturing facility is a measure of the progress ...
(Date:6/10/2017)... June 9, 2017  Shane K. Burchfield, DPM, is recognized by ... as a Podiatrist in Alabama . ... First Foot Care. He brings over 20 years of experience, as ... and healthcare, to his role. ... PC is pleased to welcome you to his practice," ...
(Date:6/8/2017)... 8, 2017  Less than a month ago, amateur ... 200,000 companies, including hospital networks, in over 150 countries. ... of the largest online extortion attempts ever recorded. With ... it is imperative that providers understand where the risks ... this — and many other very real cyber threats.  ...
Breaking Medicine Technology: