Navigation Links
Noted Vertebroplasty Expert Cites Concerns About Recently Published Study
Date:8/11/2009

Dr. Mubin Syed evaluates findings; calls for additional research

DAYTON, Ohio, Aug. 11 /PRNewswire/ -- A new study by Mayo Clinic researchers has given rise to more questions than answers about the effectiveness of vertebroplasty to treat osteoporotic spinal fractures.

Vertebroplasty is a widely used procedure in which medical cement is injected into vertebrae to relieve pain and improve mobility in patients who have osteoporotic fractures. This study, funded by the National Institutes of Health, was the first of its kind, using a double-blinded research model to examine the impact of vertebroplasty. It was published last week in The New England Journal of Medicine to mixed reviews by the medical community.

"This was an extremely interesting study, but the results are far from conclusive due to several weaknesses in the method used. Additional research is definitely indicated," said Dr. Mubin I. Syed, a neuroradiologist and diagnostic, interventional and vascular radiologist.

One major issue cited by Dr. Syed was the small size of the study group. To demonstrate statistical differences between groups requires that the research team enroll enough patients for the statistics to have meaning. The original group size for the Mayo Clinic study was to be 250 patients. Due to difficulties in recruiting participants, the final group size was reduced to 131 people, nearly half of the original design.

"This is important," explained Dr. Syed, "because the trends in the data show that if the study had enough patients, the group receiving vertebroplasty could have demonstrated a clinically meaningful improvement in pain. It is therefore surprising that a study that was showing a trend toward statistical significance was terminated early with only half the number of patients recruited. A huge doubt now remains as to whether a study with the original intended group size would have yielded a different outcome."

Additionally, selection bias could have also played a large part in the study's results. "Only 131 out of 431 (30.4 percent) eligible patients elected to participate, increasing the potential for selection bias," noted Dr. Syed.

A third issue was the crossover rate for patients who received the control or "placebo" procedure. Patients in the trial were able to "cross over" and get the other treatment after one month.

"Even though they had no confirmation of which treatment they received, nearly four times as many patients or 43 percent who had the control treatment crossed over to have vertebroplasty performed, compared to 12 percent of vertebroplasty patients who switched," said Dr. Syed.

The final issue to consider is that the control procedure included injecting 0.25 percent of bupivicaine into the periosteum of the pedicles. "The problem," explained Dr. Syed, "is that this resembles a medial branch block for the treatment of facet-related pain. The duration of relief following medial branch block is variable, but may last for several weeks."

He added that many patients with compression fractures have concurrent facet-related pain due to stress on the facet joint as a result of the fracture.

"I applaud Dr. Kallmes for his work. His study is very interesting, but I don't think it's conclusive. Additional research is needed to truly assess the efficacy of vertebroplasty," said Dr. Syed.

Dr. Syed is on staff at Good Samaritan Hospital and Dayton Heart Hospital in Dayton. He is also a founding partner of Dayton Interventional Radiology. In addition, Dr. Syed has participated in clinical trials and published several papers on vertebroplasty.


'/>"/>
SOURCE Dr. Mubin I. Syed
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Signs of Depression Noted in Second Graders
2. UPDATE: Swine Flu Spread Will Trigger Difficult Legal Questions for Employers Says Noted Pillsbury Attorney
3. Swine Flu Plans Triggering Difficult Legal Questions, Says Noted Pillsbury Attorney
4. Kouros Azar, M.D. (doctorazar.com), Noted Plastic and Reconstructive Surgeon, Offers Top 10 Tips to Patients to Help Celebrate National Patient Safety Awareness Week
5. Noted State Government Medical Director Dr. Stephen Saunders To Join APS Healthcare
6. Three Noted Women of Valor to be Honored at Los Angeles Jewish Home Gala Dinner
7. 4th annual Templeton-Cambridge fellowships awarded to 10 noted journalists
8. Noted Litigator Peter Diedrich Joins Musick Peeler & Garrett LLP
9. 39 Noted Performing Artists Urge Congress to Fix Flaws in Presidents Global AIDS Plan
10. Los Angeles Jewish Home Support Group Continues High-Profile Speaker Program With Noted Legal Scholar and Expert Laurie L. Levenson
11. Arizona Pain Specialists Contend Recent Vertebroplasty Studies are Misleading: Studies Actually Show it is Effective at Reducing Pain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... May 26, 2016 , ... On May 23rd during the National ... Science® and international water advocate, was honored by Ashram, Inc. as the world’s foremost ... who knelt on the banks of the Nile to fill their red clay pots ...
(Date:5/26/2016)... ... May 26, 2016 , ... The introduction of our ... PROTECTION TO YOUR HEAD ™”. , “We are proud to introduce Meghan ... football front we have Brian Quick, wide receiver for Los Angeles who was a ...
(Date:5/26/2016)... ... 26, 2016 , ... Metcalf & Associates’ Maureen Metcalf ... experience in leading technology and human resources operations for health care, education, banking, ... be featured on Metcalf’s VoiceAmerica radio show , Innovative Leaders Driving Thriving ...
(Date:5/26/2016)... , ... May 26, 2016 , ... May 2016 – ... so central to popular cosmetic improvement efforts. Record numbers of clients now ask about ... prominent or pouty, says Kally Papantoniou, MD, of Advanced Dermatology P.C. , ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... is happy to announce the launch of its brand equity product, Brandvantage. ... to reflect the dynamic landscape of modern consumer decision-making. The proprietary framework ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... New Zealand , May 24, 2016 ... and informatics solutions for the healthcare sector, has been named ... New Zealand Hi-Tech Awards 2016. Dr Bruce ... fantastic acknowledgement for our team.  It,s really good to be ... burden healthcare internationally. Our products are used in 35 countries ...
(Date:5/24/2016)... Los innovadores de COMBO[TM], ... introduce catéteres para la intervención de extremidades inferiores ... global especializada en el suministro de soluciones vasculares ... incluyendo productos para tratar la enfermedad arterial periférica. ... los dispositivos de primera entrada de la compañía ...
(Date:5/23/2016)... , May 23, 2016 ... Handling Equipment Market by Product (Wheelchair, Scooters, Medical ... (Bariatric Care, Critical Care, Wound), Accessories (Lifting, Transfer) ... to 2021", published by MarketsandMarkets, the patient handling ... Billion by 2021 at a CAGR of 10.5% ...
Breaking Medicine Technology: