Navigation Links
Notch-ing glucose into place
Date:1/27/2008

A novel gene called rumi regulates Notch signaling by adding a glucose molecule to the part of the Notch protein that extends outside a cell, said researchers from Baylor College of Medicine in Houston and Stony Brook University in New York in a report that appears today in the journal Cell.

Cellular signaling governed by the Notch protein determines cell fate determination and differentiation.

The complete loss of rumi causes a temperature-dependent defect in Notch signaling, an unusual phenomenon said Dr. Hugo Bellen, professor of molecular and human genetics at BCM and director of the program in developmental biology. He is also a Howard Hughes Medical Institute investigator.

Bellen and his colleagues discovered the genes effect on bristles in the fruit fly. These bristles are external sensory organs that can be easily screened for changes involved in Notch signaling. Indeed, loss of Notch signaling causes loss of these external sensory organs. Fruit flies that lack the rumi protein have a higher than normal density of bristles on the thorax, indicating a subtle loss of Notch activity. However, at 25 degrees C, the bristles are lost, which suggests a severe loss of Notch signaling.

The activity of the Notch receptor needs to be inactivated in one cell to allow it to become different from the other daughter cell, and this process is used reiteratively in many consecutive cell divisions. For example, if Notch is activated inappropriately in cells of the blood lineage, it will cause leukemia in humans, said Bellen.

It is also a key gene to specify neurons in the peripheral and central nervous system, said Bellen. When embryos lack a functional Notch protein, they have far too many neurons. The same phenomenon can be observed in rumi mutant embryos.

In animals with mutated rumi, the Notch protein accumulates in the membrane and fails to become activated. Similarities between rumi and some sugar-modifying
'/>"/>

Contact: Glenna Picton
picton@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists explain how insulin secreting cells maintain their glucose sensitivity
2. Once-Weekly Exenatide Showed Statistical Superiority in Glucose Control Compared to BYETTA in Head-to-Head Study
3. Increased glucose level is a strong risk factor for colorectal cancer
4. Got sugar? Glucose affects our ability to resist temptation
5. Monotherapy BYETTA(R) Showed Significant Improvement in Glucose Control and Weight Loss in Adults with Type 2 Diabetes
6. MultiVu Video Feed: WELCHOL (R) (COLESEVELAM HCL) RECEIVES FDA APPROVAL FOR GLUCOSE CONTROL IN ADULTS WITH TYPE 2 DIABETES MELITUS
7. Welchol(TM) (colesevelam HCl) Receives FDA Approval to Reduce Blood Glucose in Adults with Type 2 Diabetes
8. NYC-area 1st: Morgan Stanley Childrens Hospital performs transcatheter pulmonary valve replacement
9. IRIDEX Announces Closing of $5.0 Million Private Placement
10. Academy releases emergency preparedness tools to enable millions more people to shelter in place
11. Pill Equals Injection in Preventing Clots After Hip Replacement
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... ... July 01, 2015 , ... OncLive® will team ... America (HCA), as it further expands its Strategic Alliance Partnership Program for raising ... new partnership, OncLive’s editorial and marketing teams will collaborate with Sarah Cannon to ...
(Date:7/1/2015)... ... July 01, 2015 , ... The 28th annual Charity Horse Show hosted ... 11, 2015, at 6 p.m. in Pugh Bourne Park, 343 Oakfield Road. The event ... petting zoo, an Elvis impersonator, a silent auction and concessions. , Horses and riders ...
(Date:7/1/2015)... ... July 01, 2015 , ... ... author Lisa Stolzenberg, a Professor in FIU’s School of International and Public Affairs. ... 17 years who participated in the National Survey on Drug Use and Health, ...
(Date:7/1/2015)... ... 2015 , ... Element Blue ™, a leading IT ... has received trademark protection for its SensorInsight® computer software platform. SensorInsight® is used ... sources providing an environment where users can view and compare real-time and historic ...
(Date:7/1/2015)... ... July 01, 2015 , ... Bunion Bootie, the newest and ... two or more Bunion Booties directly from their website, http://www.BunionBootie.com can ... misaligned toes and its ultra thin properties allow for protection against rubbing footwear ...
Breaking Medicine News(10 mins):Health News:OncLive® Welcomes Sarah Cannon Cancer Network to Its Strategic Alliance Partnership Program 2Health News:OncLive® Welcomes Sarah Cannon Cancer Network to Its Strategic Alliance Partnership Program 3Health News:Researchers find that medical marijuana laws increase recreational marijuana use among juveniles 2Health News:Element Blue Receives Trademark Protection from U.S. Patent and Trademark Office for Its Award Winning SensorInsight® Software 2Health News:Element Blue Receives Trademark Protection from U.S. Patent and Trademark Office for Its Award Winning SensorInsight® Software 3Health News:Element Blue Receives Trademark Protection from U.S. Patent and Trademark Office for Its Award Winning SensorInsight® Software 4Health News:Bunion Bootie, the #1 Non-Surgical Treatment for Bunion Pain, Announces Their Big Summer Sale 2
... Researchers from MetroHealth Medical Center and Case Western Reserve ... who have had previous spontaneous preterm births with 17 ... another preterm birth would consequently reduce both short-term and ... year. The results of their study are reported in ...
... medication labels in languages other than English, few New ... limited-English patients face serious risk of medication error, according ... Medicine presented today at the annual meeting of the ... ,"Imagine, as an English speaker, picking up ...
... out of three sexually active older adults infected with HIV ... researchers//. A survey of 260 HIV-positive older adults found that ... were in a relationship. ,AIDs cases among the ... for Disease Control and Prevention, they will account for half ...
... the potential for medication errors, says a new study by ... May issue of the journal Medical Care. ,The ... College of Pharmacy professor Daniel C. Malone, Ph.D., who is ... Research on Therapeutics at the Critical Path Institute. ...
... for their antiretroviral medications experienced interruptions in drug ... logistical disruptions. These treatment interruptions led to the ... ,These findings by a team led ... Makerere University, Kampala, and UCSF are reported in ...
... of global warming keeps coming up from across the world. ... seawaters are killing marine life in their thousands. ... ago it was reported that a Norwegian glacier had shrunk ... a usually frozen fjord (a long narrow arm of ...
Cached Medicine News:Health News:Drug Therapy can Reduce Preterm Births and Decrease Lifetime Medical Costs 2Health News:Many NYC Pharmacies Fail to Translate Prescription Labels for Patients Who Don't Understand English 2Health News:Many NYC Pharmacies Fail to Translate Prescription Labels for Patients Who Don't Understand English 3Health News:One-Third of Sexually Active Older Adults With HIV/AIDs Has Unprotected Sex 2Health News:Pharmacists' Workload Contributes To Errors 2Health News:Resistance to Anti-HIV Drugs in Uganda Developed Due to Drug Supply Problems 2Health News:Norwegian Glacier Shrinks and Marine Life Poisoned as the Globe Warms 2Health News:Norwegian Glacier Shrinks and Marine Life Poisoned as the Globe Warms 3
(Date:7/1/2015)... Lupin , Strides ... MPP Sub-licensees to Fourteen Companies     ... expansion of its network of generic manufacturers to 14 companies ... antiretrovirals (ARVs). New companies Lupin and Strides Arcolab recently signed ... the MPP licensed from ViiV Healthcare two months after its ...
(Date:7/1/2015)... , July 1, 2015  Celsion Corporation (NASDAQ: ... announced that Michael H. Tardugno , Chairman, President ... Fitzgerald,s Inaugural Healthcare Conference on Wednesday, July 8, 2015, ... at Le Parker Meridien Hotel located at 119 W. ... 10019. A copy of the presentation will ...
(Date:7/1/2015)... Egalet Corporation (Nasdaq: EGLT ) ... on developing, manufacturing and marketing innovative pain treatments, ... and chief executive officer, is scheduled to present ... an update on Egalet,s marketed product SPRIX ... product OXAYDO ™ (oxycodone HCI, USP) tablets ...
Breaking Medicine Technology:The Medicines Patent Pool Increases its Generic Manufacturing Network to Ramp-Up Production of Low Cost Antiretrovirals (ARVs) 2The Medicines Patent Pool Increases its Generic Manufacturing Network to Ramp-Up Production of Low Cost Antiretrovirals (ARVs) 3Celsion Corporation to Present at Cantor Fitzgerald's Inaugural Healthcare Conference on July 8, 2015 2Egalet to Present at Upcoming Conferences This Summer 2Egalet to Present at Upcoming Conferences This Summer 3
... June 1, 2011 Reportlinker.com ... research report is available in ... Interventional Neurology - Global ... Market Forecasts to 2017 ...
... 2011 Repro-Med Systems, Inc., (REPR.PK) announced today that ... Administration (FDA) to begin U.S. marketing of its new ... the HIgh Flo™ RMS Subcutaneous Needle Sets.  The needle ... subcutaneous tissue.  The needle sets have previously been approved ...
Cached Medicine Technology:Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 2Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 3Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 4Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 5Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 6Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 7Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 8Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 9Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 10Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 11Reportlinker Adds Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 12FDA Approves Marketing of RMS Subcutaneous Needle Sets 2FDA Approves Marketing of RMS Subcutaneous Needle Sets 3
Compact, bench-top analyser with minimal water volume requirements and easy waste management....
Compact benchtop clinical chemistry system...
... offers easy operation, maintenance, and training. Whether you ... to the powerful VITROS 5,1 FS, the VITROS ... right the first time. Its that simple. , ... and easy-to-use. The VITROS 350 comes complete with ...
Meet Galileo, the best reason to move to automation; the best way to upgrade your capabilities....
Medicine Products: