Navigation Links
Not just clean but spotless -- Researchers show how cells tidy up
Date:1/17/2014

Autophagy or how cells tidy up

"Bang and the dirt is gone!" There are many commercials for products that claim to make the unpopular process of cleaning up easier. But it's not only our surroundings that need to be kept clean. Even our cells need to tidy up. The responsible cellular process is called autophagy, in which the coordinated action of a set of proteins removes damaged cell material or pathogens, such as bacteria, from a cell. At the same time autophagy also helps cells to survive in times of starvation by recycling the cells' own components to produce energy, similar to recycling stations in a city.

The central player in autophagy: Atg1

For some time researcher had known the key coordinator of autophagy the protein Atg1. However, how Atg1 exactly does its job remained unclear, despite the efforts of many groups worldwide. Now, the team of Claudine Kraft at the Max F. Perutz Laboratories (MFPL) of the University of Vienna showed that Atg1 modifies a set of proteins with a specific recognition sequence. In collaboration with their colleagues Gustav Ammerer at MFPL and Ben Turk at the University of Yale, they not only deciphered the recognition sequence but also determined the cellular proteins that actually contain this sequence. One, Atg9, caught the interest of the researchers in particular, as it is not only a known component of the cellular "waste bag", but also contains a stunning six of those specific recognition sequences. Daniel Papinski, first author of the study, explains: "Every cell contains specialized recycling stations. In order to dispose its waste, a cell needs to wrap it up, similar to putting garbage in a bag. This cellular trash bag can then be brought to the cellular recycling station where the waste is broken down into the re-usable parts." Atg9 is essential for this process.

How does Atg1 coordinate the packaging of cellular waste?

To test how Atg1 precisely regulates the packaging of cellular waste, the researchers altered the recognition sequences of Atg9. They found that in this case, Atg1 is unable to modify Atg9 and no autophagy, and therefore no cellular waste disposal, takes place. "This scenario is similar to that in cells that have no machinery to dispose of waste at all", says Claudine Kraft, lead author of the study. More experiments revealed that after modification by Atg1, Atg9 recruits other proteins an interplay ensuring that cellular waste is packaged and disposed of. Involuntarily, the researcher saved the crucial and most exciting experiment for last. The method they used was only described a few months ago and allows monitoring how cells package their waste live under the microscope. Daniel Papinski says: "When we looked at cells that contained Atg9 with an altered recognition sequence, which Atg1 cannot modify, we observed that the wrapping up of the cellular waste stopped prematurely. Therefore, the proper function of Atg1 and Atg9 is crucial at the early stages of the waste disposal process, when the garbage is put into 'bags'."

A detailed understanding of such fundamental cellular events is essential for the study of diseases that go hand in hand with these processes in the case of autophagy Alzheimer's disease and cancer and in the long run will help to better treat or even prevent these diseases.


'/>"/>

Contact: Lilly Sommer
lilly.sommer@mfpl.ac.at
43-142-772-4014
University of Vienna
Source:Eurekalert  

Related medicine news :

1. New Product Bridges the Link between Colon Cleanse and Weight Loss
2. Strouse Cleanroom Now ISO 7 Certified
3. School of Juicing Review
4. How to Cleanse the Body Naturally With Foods – HealthReviewCenter
5. Mold Shuts Down 8 Loughman Oaks Elementary School Classrooms, My Cleaning Products Shares Mold Removal Tip How Others Could Prevent Same Problem
6. RMB Certifies ISO Class 7 Cleanroom for Plastic Fabrication
7. Total Wellness Cleanse Review
8. How This Program Helps People Detox Their Body Naturally – HealthReviewCenter
9. Bowtrol Colon Cleansing Treatment Now Offers Extra Discount on All Orders as New Year Special
10. Weight Loss Secrets of the Master Cleanse Detox Exposed By Detox Dieter
11. Total Body Cleanse and Detox Tips to Improve Health and Wellness Released by Detox Dieter
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Not just clean but spotless -- Researchers show how cells tidy up
(Date:5/25/2016)... ... May 25, 2016 , ... The World Molecular Imaging Society ... Imaging.” The focus of ADDMI-IG will be geared towards how using molecular imaging ... Through ADDMI-IG WMIS will provide a platform for productive discussions about the implementation ...
(Date:5/25/2016)... FL (PRWEB) , ... May 25, 2016 , ... ... Cross Benefit Clearinghouse supporting the real time adjudication of medical service claims by ... providers using their current medical claims management software. The TransactRx Cross Benefit Clearinghouse ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... For more than fifty years, we've suffered ... we changed our diets to conform to the latest nutritional advice – advice that was ... the NIH, more than 2 in 3 American adults are considered to be overweight and ...
(Date:5/25/2016)... ... ... Consumer access to organic foods and grower access to food processers is about ... and other plant-based foods, will introduce the first consumer product (a new breakfast cereal) ... Organic Products. , The transitional designation means the cereal was made using at least ...
(Date:5/24/2016)... ... May 24, 2016 , ... According to an ... group of people randomly assigned to reduce the amount of calories they consumed by ... drop in body weight enjoyed better sleep, improved quality of life, and enhanced sexual ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... 2016 As illustrated by the ... month, the numbers and momentum of cannabis in the ... the billions, more research and development push the sector ... of Legal Marijuana Markets Report  from from ArcView Market ... of the increase in sector is attributed to adult ...
(Date:5/25/2016)... Texas , May 25, 2016 ... the issuance to it by the US Patent ... The company,s technology includes proprietary processes for electronic ... for health and wellness programs, HIPAA compliance and ... "Our technology ...
(Date:5/25/2016)... , May 25, 2016 ... the precision of circulating tumour DNA (ctDNA) analysis ... the appointment of Professor Clive Morris ... leadership across the clinical development programme, scientific collaborations, ... help deliver significant improvements in clinical outcomes for ...
Breaking Medicine Technology: