Navigation Links
Not in the mood but want to be? New studies bring women hope
Date:12/4/2013

CLEVELAND, Ohio (December 4, 2013)For women, passing midlife can deal a blow to their sex drive. But two new studies just published online in Menopause, the journal of The North American Menopause Society, offer hope to women who want to get their sexual mojo back.

No testosterone treatment for women has yet passed muster with the FDA. An important step toward developing a successful and safe treatment for women after natural or surgical menopause is to find out how much testosterone is really needed to bring desire back. One of these studies looked for that, as well as how much it took to produce other testosterone-related effects, such as increases in lean body mass, in women who had undergone hysterectomy. The other study tested a nonhormonal therapy, flibanserin, which did not meet FDA approval before but has since been resubmitted to the agency.

When FDA first reviewed flibanserin for this purpose in 2010, the agency did not think it made a difference that was meaningfully different from placebo. This new study in women who had very low desire and were distressed about it showed some statistically significant differences. The women who took flibanserin (100 mg/day at bedtime) had increases in the number of satisfying sexual encounters (SSEs) and in a standard score of desire that were statistically better than placebo. Thirty percent of the women experienced side effects, including dizziness, sleepiness, nausea, and headache, but only 8% stopped taking the drug because of them.

The testosterone study included women ages 21 to 60 who had undergone hysterectomy. They all had testosterone levels that were lower than the average for healthy young women. Because the ovary continues to secrete male hormones after menopause, there is usually little decrease in testosterone levels for women who go through menopause naturally, but in women who undergo any type of hysterectomy, testosterone levels drop substantially. Women who also have one or both ovaries removed, even if they take estrogen, have worse sexual function than women who still have one or both ovaries. All the women took estrogen and then also got injections of placebo or of different doses of testosterone enanthate for six months.

Only the women who got the highest dose25-mg weeklyhad statistically significant improvements in their libido and other measures of sexual function as well as in lean body mass and muscle strength. That dose raised testosterone levels to about 210 ng/dL, which is nearly five to six times higher than a healthy, normal level. So simply raising low testosterone levels to what's normal won't improve sexual function and these other measures, concluded the investigators. But is it a dangerous level?

The investigators saw no serious adverse effects. Total and LDL cholesterol, triglycerides, and fasting glucose didn't change significantly in the women who got testosterone. Levels of HDL, the "good cholesterol," did decrease, but not in a statistically significant way. Nevertheless, cautioned the authors, the cardiovascular and metabolic risks need to be investigated in long-term trials.

"Keeping hormone levels within the normal range for your gender and age is the safest approach. Hormones affect many systems in the body, and it takes a large and long-term study to identify side effects. One recent well-designed study in men reported that mortality was greater among older men taking testosterone. More is not necessarily better when it comes to hormones," says The North American Menopause Society Executive Director Margery Gass, MD.


'/>"/>

Contact: Eileen Petridis
epetridis@fallscommunications.com
216-696-0229
The North American Menopause Society (NAMS)
Source:Eurekalert

Related medicine news :

1. End-Year Special Offer on Research Studies by Current Partnering Now Available at MarketPublishers.com
2. Risperdal Lawsuit News: Bernstein Liebhard LLP Notes Johnson & Johnson Bid to Keep Clinical Studies Under Seal
3. The importance of standardizing drug screening studies
4. Diet Doc Hormone Diets & Weight Loss Plans Announces New Diet Plans Helping Women Lose Excess Fat Prior to Pregnancy, Which Studies Show Leads to Fewer Complications
5. Contract Research Organization WCCT Global Announces Clinical Trial Patient Recruitment Services for International Clinical Studies
6. Studies Show Stand Up Desks Spur Productivity & Creativity
7. Study Funded by National Foundation for Cancer Research Reveals Imaging Studies May Predict Tumor Response to Anti-Angiogenic Drugs
8. New case studies link smoking synthetic marijuana with stroke in healthy, young adults
9. Studies explore potential origins of addiction and treaments
10. Studies explore potential origins of addiction and treatments
11. Studies pinpoint specific brain areas and mechanisms associated with depression and anxiety
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... ... ... Walk Away”: a captivating and romantic sequel to the romantic story of a ... creation of published author, Larry R. Sherman, a retired chemistry professor from the University ... well as four novels. , Though the book opens in 1947, when Edward ...
(Date:8/22/2017)... ... ... “Glimpses Of Light”: is a unique and thought inspiring guide toward self-discovery and ... author, J.M. Shepherd, a writer, teacher, traveler, and metaphysician, the author has spent most ... “Love is one of the least understood and yet most sought-after pleasures known to ...
(Date:8/22/2017)... (PRWEB) , ... August 22, 2017 , ... Although Labor ... of July, many communities have begun providing weekend displays, and numerous households celebrate the ... humans, they can be downright terrifying for pets. , Kris Zambo, owner of ...
(Date:8/21/2017)... ... 21, 2017 , ... Los Angeles area medical group Beverly ... year 2017-2018, Christina M. Busuito, M.D. and Lukasz Swistun, M.D. This one year ... Reconstructive Surgery. The candidate will have the opportunity to work with leading ...
(Date:8/21/2017)... ... 2017 , ... Marathon running has surged in popularity in ... running increases exposure to ultraviolet radiation, a carcinogen that promotes skin cancer. Studies ... half may be adequately protecting themselves with proper clothing and sunscreen. , ...
Breaking Medicine News(10 mins):
(Date:8/4/2017)... Aug. 3, 2017  Agragen, LLC, a ... in the biopharmaceutical, nutraceutical, and aquacultural feed sectors, ... its lead drug candidates, AGR131.  This drug is ... from the blood of patients suffering from inflammatory ... bowel disease. ...
(Date:8/2/2017)... Aug. 2, 2017 CaryRx, a next-generation full-service pharmacy, ... service for patients in the Washington D.C. ... pharmacy by providing delivery of medications through the convenience of ... delivery or delivered within one hour to any location in ... to bring this invaluable service to Washington D.C. ...
(Date:7/28/2017)... 2017 Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), ... ended June 30, 2017, and updated its financial outlook ... For the fiscal third quarter, Hill-Rom reported earnings ... diluted share in the prior-year period. These results reflect ... diluted share primarily related to the non-cash write-down of ...
Breaking Medicine Technology: