Navigation Links
Not all lung cancer patients who could benefit from crizotinib are identified by FDA-approved test
Date:8/28/2012

Break apart a couple worm-like chromosomes and they may reconnect with mismatched tips and tails such is the case of the EML4-ALK fusion gene that creates 2-7 percent of lung cancers. Almost exactly a year ago, the FDA approved the drug crizotinib to treat these ALK+ lung cancer patients, who were likely never smokers. Informed doctors use the test called a FISH assay to check for the EML4-ALK fusion gene, and then if the test is positive, ALK+ patients benefit greatly from crizotinib.

A recent University of Colorado Cancer Center case study published in the Journal of Thoracic Oncology describes the never-before-seen case of a patient who tested negative for EML4-ALK fusion based on the well-defined criteria for FISH assay as approved by FDA, but nevertheless experienced remission after treatment with crizotinib.

"The case implies that not all patients who might benefit from the drug are captured by the FDA-approved FISH assay. Perhaps despite the FDA pairing of crizotinib with FISH, other assays or other criteria for ALK/FISH positivity could be used," says paper co-author, Fred R. Hirsch, MD, PhD, investigator at the CU Cancer Center and professor of medical oncology and pathology at the CU School of Medicine.

In fact, it was by chance that after the patient's negative FISH, Hirsch and colleagues chose to look deeper. Besides using FISH to stain sections of chromosomes with the EML4-ALK fusion gene, the team used immunohistochemistry to look for the protein products of this fusion gene not the faulty plans but the faulty results. Sure enough, in this case, the patient had the EML4-ALK fusion protein but apparently without the typical EML4-ALK fusion gene that should code for it.

The team looked deeper, using next-gen sequencing to discover what, exactly, was going on in the short arm of chromosome number 2, which harbors the EML4-ALK fusion gene. What they found looked less like a pair of clean breaks that reatta
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Breast Cancer Drug Might Help Men on Prostate Cancer Therapy
2. Reducing the side effects of treatment for prostate cancer
3. Accuracy of narrow band imaging with colonoscopy allows for distal non-cancerous polyps to be left in place
4. Daily Aspirin May Help Fight Prostate Cancer, But Not Breast Cancer
5. WSU researcher documents links between nutrients, genes and cancer spread
6. Excess Pounds Raise Risk of Breast Cancer Recurrence, Death: Study
7. Johns Hopkins team finds ICU misdiagnoses may account for as many annual deaths as breast cancer
8. Compounds activate key cancer enzyme to interfere with tumor formation
9. Lack of sleep found to be a new risk factor for aggressive breast cancers
10. Cancer vaccine Special Focus series published in Human Vaccines & Immunotherapeutics
11. Obese and overweight women face increased risk of recurrence of most common type of breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... (PRWEB) July 29, 2014 Parker Waichman ... rights of victims injured by defective drugs and medical ... filed by plaintiffs in Canada who allege that they ... events with the low testosterone injection Delatestryl (Court ... 22, 2014 in the Ontario Superior Court of Justice. ...
(Date:7/29/2014)... Colorado (PRWEB) July 29, 2014 Daily Gossip ... a powerful and holistic system that will teach users how ... tried by thousands of people, from all over the world. ... the symptoms of this disorder in as quickly as 12 ... be gone faster than imagined. , The Fibroids Miracle ...
(Date:7/29/2014)... Daily Gossip indicates in its Natural Vitiligo ... by a popular nutritionist and health specialist. Michael Dawson ... this disorder, but none of them worked. , According ... having to look for an alternative vitiligo treatment, which ... method, too, to become vitiligo free. , To ...
(Date:7/29/2014)... July 29, 2014 (HealthDay News) --,The time at which ... their chances for survival, new research suggests. Showing ... or during holidays is associated with a 13 percent ... hours, researchers report. Every year, more than 250,000 ... severe type of heart attack, which is caused by ...
(Date:7/29/2014)... Randy Dotinga HealthDay Reporter ... When most children take on a task, various brain ... neuro-boosting activity in kids with autism, according to a ... symptoms of autism displayed even less of this "brain ... flexibility often causes difficulty when children with autism are ...
Breaking Medicine News(10 mins):Health News:Class Action Lawsuit in Canada Alleges Manufacturer of Delatestryl Testosterone Injection Failed to Warn of Cardiovascular Risks, Parker Waichman LLP Reports 2Health News:Class Action Lawsuit in Canada Alleges Manufacturer of Delatestryl Testosterone Injection Failed to Warn of Cardiovascular Risks, Parker Waichman LLP Reports 3Health News:Amanda Leto’s Fibroids Miracle Review Reveals Clinically Proven Uterine Fibroids Cure System 2Health News:Natural Vitiligo Treatment System Review Reveals Michael Dawson’s New Vitiligo Cure Program 2Health News:Heart Attack Patients Treated at Night, Weekends May Have Worse Outcomes 2Health News:Less Flexibility Seen in Brain Wiring of Kids With Autism: Study 2Health News:Less Flexibility Seen in Brain Wiring of Kids With Autism: Study 3
... study accepted for publication in The Endocrine Society,s ... demonstrated a novel and accurate test for early diagnosis ... to 2,000 female live births and early diagnosis allows ... conditions including cardiac and renal problems. Turner syndrome ...
... , TUESDAY, Dec. 7 (HealthDay News) -- Electronic cigarettes ... University of California researchers say. Their study ... devices that contain nicotine, flavorings and other chemicals. The ... and Drug Administration cited five e-cigarette distributors for poor ...
... Summit and Left Main Coronary Interventions Course is ... and new developments in therapeutic procedures essential for ... coronary occlusions and left main coronary interventions. Topics ... and why to open a chronic total occlusion ...
... 7 (HealthDay News) -- The presence of a certain biomarker ... increased risk of death from all causes, a new study ... T (cTnT) -- a heart-specific protein that serves as ... cTnT levels are associated with a number of chronic diseases ...
... TUESDAY, Dec. 7 (HealthDay News) -- Teens who are allowed ... smoking than teens whose parents bar them from viewing mature ... the study authors estimated that if 10- to 14-year-olds were ... to smoke could drop two to threefold. , However, ...
... Dec. 7 (HealthDay News) -- Teens who have health problems ... friendships are stronger than they actually are, new research shows. ... took part in a 1994-1996 survey that asked them about ... teens rated their health as "excellent" or "very good." The ...
Cached Medicine News:Health News:E-Cigarettes Should Be Banned Until Made Safe: Study 2Health News:CTO Summit & Left Main Coronary Interventions Course to be held Feb. 14-16, 2011, in NYC 2Health News:New Test Links Blood Protein to Heart Disease, Diabetes Risk 2Health News:Watching R-rated Movies Ups Odds of Teens Smoking 2Health News:Watching R-rated Movies Ups Odds of Teens Smoking 3Health News:Teens' Poor Health Linked to Fewer Friends 2
(Date:7/29/2014)... , July, 29  2014 ISPE—the International Society ... John Bournas as President and CEO, ... to leave the Society last fall.  Mr. Bournas ... in the healthcare association industry as well as ... a clear vision for the expansion of its ...
(Date:7/29/2014)... , July 29, 2014 McGraw-Hill Education ... for the science, technical, and medical communities, has announced ... first off-line mobile application of the world-renowned medical education ... new AccessMedicine App , available for download onto ... now be able to gain access to valuable ...
(Date:7/29/2014)... , July 29, 2014  Instrumentation Laboratory (IL) today announced ... new corporate logo. This is part of a comprehensive rebranding ... Founded in Boston, MA , in 1959, ... companies since 1992.  Other companies in the group include Inova ... Systelab ( Barcelona, Spain ).  Like IL, these ...
Breaking Medicine Technology:ISPE Hires Healthcare Association Exec as CEO 2ISPE Hires Healthcare Association Exec as CEO 3McGraw-Hill Education Professional's AccessMedicine App Delivers Instant Access to Essential Diagnostic Tools 2McGraw-Hill Education Professional's AccessMedicine App Delivers Instant Access to Essential Diagnostic Tools 3Instrumentation Laboratory Unveils New Corporate Brand 2Instrumentation Laboratory Unveils New Corporate Brand 3
... but,Underscore Need for Improved Patient Communication, Lifestyle,Management ... Elevated,Blood Pressure, NEW YORK, May 19, 2007 ... Harris Interactive(R) for the Hypertension Education,Foundation (HEF) ... Inc. (ASH) Twenty-Second Annual Scientific Meeting,and Exposition ...
... SAN FRANCISCO--(BUSINESS WIRE)--May 21, 2007 - Medical,professionals ... problem of,hospital-acquired gram-negative pneumonia may have a ... candidate being,developed by Nektar Therapeutics (Nasdaq:NKTR)., Results ... the use of,NKTR-061 (Inhaled Amikacin) to treat ...
Cached Medicine Technology:Hypertension Education Foundation Survey Results Announced At,American Society For Hypertension Annual Meeting Suggests Improved,Control Of High Blood Pressure, But Misconceptions Still Exist 2Hypertension Education Foundation Survey Results Announced At,American Society For Hypertension Annual Meeting Suggests Improved,Control Of High Blood Pressure, But Misconceptions Still Exist 3Hypertension Education Foundation Survey Results Announced At,American Society For Hypertension Annual Meeting Suggests Improved,Control Of High Blood Pressure, But Misconceptions Still Exist 4Hypertension Education Foundation Survey Results Announced At,American Society For Hypertension Annual Meeting Suggests Improved,Control Of High Blood Pressure, But Misconceptions Still Exist 5Hypertension Education Foundation Survey Results Announced At,American Society For Hypertension Annual Meeting Suggests Improved,Control Of High Blood Pressure, But Misconceptions Still Exist 6Hypertension Education Foundation Survey Results Announced At,American Society For Hypertension Annual Meeting Suggests Improved,Control Of High Blood Pressure, But Misconceptions Still Exist 7Nektar Threraputics Announces Phase 2a Clinical Results Regarding,the use of NKTR-061 (Inhaled Amikacin) to Treat Gram-Negative,Hospital-Acquired Pneumonia Presented at the Annual American,Thoracic Society International Conference 2Nektar Threraputics Announces Phase 2a Clinical Results Regarding,the use of NKTR-061 (Inhaled Amikacin) to Treat Gram-Negative,Hospital-Acquired Pneumonia Presented at the Annual American,Thoracic Society International Conference 3Nektar Threraputics Announces Phase 2a Clinical Results Regarding,the use of NKTR-061 (Inhaled Amikacin) to Treat Gram-Negative,Hospital-Acquired Pneumonia Presented at the Annual American,Thoracic Society International Conference 4Nektar Threraputics Announces Phase 2a Clinical Results Regarding,the use of NKTR-061 (Inhaled Amikacin) to Treat Gram-Negative,Hospital-Acquired Pneumonia Presented at the Annual American,Thoracic Society International Conference 5Nektar Threraputics Announces Phase 2a Clinical Results Regarding,the use of NKTR-061 (Inhaled Amikacin) to Treat Gram-Negative,Hospital-Acquired Pneumonia Presented at the Annual American,Thoracic Society International Conference 6Nektar Threraputics Announces Phase 2a Clinical Results Regarding,the use of NKTR-061 (Inhaled Amikacin) to Treat Gram-Negative,Hospital-Acquired Pneumonia Presented at the Annual American,Thoracic Society International Conference 7Nektar Threraputics Announces Phase 2a Clinical Results Regarding,the use of NKTR-061 (Inhaled Amikacin) to Treat Gram-Negative,Hospital-Acquired Pneumonia Presented at the Annual American,Thoracic Society International Conference 8Nektar Threraputics Announces Phase 2a Clinical Results Regarding,the use of NKTR-061 (Inhaled Amikacin) to Treat Gram-Negative,Hospital-Acquired Pneumonia Presented at the Annual American,Thoracic Society International Conference 9Nektar Threraputics Announces Phase 2a Clinical Results Regarding,the use of NKTR-061 (Inhaled Amikacin) to Treat Gram-Negative,Hospital-Acquired Pneumonia Presented at the Annual American,Thoracic Society International Conference 10Nektar Threraputics Announces Phase 2a Clinical Results Regarding,the use of NKTR-061 (Inhaled Amikacin) to Treat Gram-Negative,Hospital-Acquired Pneumonia Presented at the Annual American,Thoracic Society International Conference 11
... Advia 2400 has minimal ... (as low as 2 ... (40 L/hour) thus maximizing ... universal rack handler facilitates ...
Iron Total (TIBC) (Iron Buffer + Iron Color=Std.). An Automated analyzer test kits....
... For determination of HDL-cholesterol ... Hitachi 717. Specific immunochemical inhibition ... established reference methods. Endpoint assay. ... stable, ready-to-use reagent. Available with ...
Cholesterol/HDL with 200 tests....
Medicine Products: