Not All Colon Cancer Patients Need Chemother... (ancer. These are patients who sometimes ...)

Not All Colon Cancer Patients Need Chemotherapy: Study

Date:5/16/2008

ancer. These are patients who sometimes get chemo and sometimes do not," Sargent said. "We have sought for a long time to try to determine if there was a way to predict which patients might benefit from chemo and which might not."

But, Sargent added, "we felt that in order to really recommend this in clinical practice, we needed to validate it."

The new study analyzed data from 1,027 patients in the United States as well as Canada, France and Italy who had participated in previous trials. Sixteen percent had dMMR.

"The goal was to validate that the 15 percent of patients who have defective mismatch repair did not receive any benefit from 5-FU therapy, and that is indeed exactly what we found," Sargent said.

"We now feel this is appropriately validated for clinical use," he added.

In fact, there is already a simple test for this type of cancer.

"The test is available and, in a patient with stage 2 disease being considered for treatment with chemotherapy, we think that this test would be useful," Sargent said.

More information

The National Cancer Institute has more on colon cancer.

SOURCES: Daniel Sargent, Ph.D., professor of biostatistics, Mayo Clinic, Rochester, Minn.; May 15, 2008, presentation, American Society of Clinical Oncology annual meeting, Chicago

0

GOOD

Page: 1 2
Related medicine news :

1. Study Suggests Green Tea May Support the Medical Treatment of Stomach and Colon Cancer
2. Discovery of a novel mechanism for the development of colon cancer
3. Protein May Trigger Colon Cancer
4. Monoclonal antibody Hb3: A marker for colon cancer progression or as a therapeutic target?
5. $450,000 sweetener in colon cancer battle
6. Study finds that competency in colonoscopy requires experience with 150 cases or more
7. USC study finds evidence of gender-related differences in development of colon cancer
8. New Drug Duo Helps Cut Colon Cancer Risk
9. New Drug Duo Helps Fight Colon Cancer
10. New Treatments Help Fight Liver, Colon Cancer
11. Colon cancer risk perception associated with screening behavior

Post Your Comments:

(Date:1/8/2009)..., study suggests , , THURSDAY, Jan. 8 (...rongly they would react to racist acts, a new Cana...y participants at York University, in Toronto, sti... person rather than a black one, even after their ...rson when he left the room. , "And the racist...

(Date:1/8/2009).../ -- Allscripts-Misys Healthcare,Solutions, Inc.,...llscripts or,the Company), today announced its fi...d November 30, 2008. , (Logo: http://www.n...) , The Company,s results for the three and...ts from legacy Allscripts for the period of Octobe...

(Date:1/8/2009)...wire/ -- A new educational Web site offers expert ...ical products and medical devices from the Agency ...Education and Research on Therapeutics (CERTs), a ...eading research centers nationwide. The Clinician...AIN ) http://www.chainonline.org links clinician...

(Date:1/8/2009)...Call/ -- Heska Corporation (Nasdaq: HSKA ) annou... Heska Corporation Invites You to Join Its Fourth... Conference Call on the Web, When: Monda... www.heska.com (click on the Q4 and Year-End 200...age of this website)., How: Live over t...

[0] Many Turn Blind Eye to Racism [0] Allscripts Reports Fiscal 2009 Second Quarter Results [0] AHRQ Announces New Web Site on Emerging Issues in Medical Therapeutics [0] Webcast Alert: Heska Announces Fourth Quarter and Year-End 2008 Earnings Conference Call Webcast

...esearchers say eating fish could help keep ones mi... high intake of cholesterol and saturated fat have...middle age. More and more research is showing what... for dementia. For example, studies have shown tha...

... risk factor, which accounts for about half of the...e is now a more dependable, less expensive test to... the NMP22 tumor marker assay in 1,331 patients at...s found that of the 79 patients shown to have blad...

...ound in the air in many inner-city homes could be ...n children say researchers. According to researche...ously exposed to the allergy-causing substance fou... the air and exposure increases their risk for dev...

...sted early onset wheezing is associated with high ...d bronchial hyper-responsiveness. Children with th... more severe asthma. However, some children who de...ith the same characteristics as those who begin wh...

Other Medicine News:

Consumption Of Fish Could Reduce The Risk Of Dementia More Dependable Screening Test For Bladder Cancer Mouse Allergen Found In Homes Could Trigger Asthma In Kids Childhood Wheezing Could Be Hereditary

(Date:1/7/2009)... ImQuest Life Sciences announced today the success...nd Drug Administration to initiate human clinical ...r IQP-0410. ImQuest anticipates initiating their P...410 is a novel small molecule inhibitor of HIV whi...criptase inhibitor (NNRTI). The compound possesses...

(Date:1/6/2009)...from prior U.S., U.K. and China Trials , , SAN .... (VTI), a development stage company targeting liv... begun for a randomized, controlled, multi-center,...orporeal Liver Assist Device (ELAD) as a treatment... three protocols. The study is open for enrollment...

(Date:1/6/2009)...ewswire/ -- Sequella, Inc., a clinical-stage bioph...ic potential, announced today that SQ109, its lead...(TB), was the first drug approved for evaluation i...port Vaccine Company LLC and Quintiles Transnation...e of Allergy and Infectious Diseases (NIAID), Nati...

(Date:1/5/2009)...ne Pharmaceuticals announced today that it has ini...otein kinase inhibitor, CX-4945, in patients with ...tiple myeloma. The primary endpoints of the oral d...tolerance and PK properties of CX-4945 and to sele...dition, multiple mechanism-related pharmacodynamic...

Breaking Medicine Technology:ImQuest Submits Investigational New Product Application to the Food and Drug Administration to Initiate HIV Therapeutic Clinical Trials with IQP-0410 2 ELAD(R) Liver Support System Study Initiated at Multiple U.S. Centers 2 ELAD(R) Liver Support System Study Initiated at Multiple U.S. Centers 3 Sequella Lead Drug Compound SQ109 Selected for Phase 1B Clinical Trial Program 2 Sequella Lead Drug Compound SQ109 Selected for Phase 1B Clinical Trial Program 3 Cylene Pharmaceuticals Initiates Phase I Trial With CX-4945 -Breakthrough First-in Class Inhibitor of CK2 2 Cylene Pharmaceuticals Initiates Phase I Trial With CX-4945 -Breakthrough First-in Class Inhibitor of CK2 3 PLC Systems Receives Full FDA Approval for Pivotal Study of RenalGuard 28TM 29 in The U S 3500 1 PLC Systems Receives Full FDA Approval for Pivotal Study of RenalGuard 28TM 29 in The U S 3500 2 PLC Systems Receives Full FDA Approval for Pivotal Study of RenalGuard 28TM 29 in The U S 3500 3 PLC Systems Receives Full FDA Approval for Pivotal Study of RenalGuard 28TM 29 in The U S 3500 4 China Nepstar Chain Drugstore Reports Third Quarter 2008 Results 30671 1 China Nepstar Chain Drugstore Reports Third Quarter 2008 Results 30671 2 China Nepstar Chain Drugstore Reports Third Quarter 2008 Results 30671 3 China Nepstar Chain Drugstore Reports Third Quarter 2008 Results 30671 4 China Nepstar Chain Drugstore Reports Third Quarter 2008 Results 30671 5 China Nepstar Chain Drugstore Reports Third Quarter 2008 Results 30671 6 China Nepstar Chain Drugstore Reports Third Quarter 2008 Results 30671 7 China Nepstar Chain Drugstore Reports Third Quarter 2008 Results 30671 8 China Nepstar Chain Drugstore Reports Third Quarter 2008 Results 30671 9 China Nepstar Chain Drugstore Reports Third Quarter 2008 Results 30671 10 China Nepstar Chain Drugstore Reports Third Quarter 2008 Results 30671 11 Sentillion Appoints New UK Sales Manager 30669 1 Sentillion Appoints New UK Sales Manager 30669 2 Lt Col Weinstein New Book 3A Universal Health Care Will Not Work Unless 30664 1 Lt Col Weinstein New Book 3A Universal Health Care Will Not Work Unless 30664 2 Lt Col Weinstein New Book 3A Universal Health Care Will Not Work Unless 30664 3 Lt Col Weinstein New Book 3A Universal Health Care Will Not Work Unless 30664 4

[0] ImQuest Submits Investigational New Product Application to the Food and Drug Administration to Initiate HIV Therapeutic Clinical Trials with IQP-0410 [0] ELAD(R) Liver Support System Study Initiated at Multiple U.S. Centers [0] Sequella Lead Drug Compound SQ109 Selected for Phase 1B Clinical Trial Program [3] Cylene Pharmaceuticals Initiates Phase I Trial With CX-4945 -Breakthrough First-in Class Inhibitor of CK2

...gress of European Hematology,Association (EHA) -, ...ll/ --,Immunomedics, Inc. , a biopharmaceutical co...to treat cancer and other serious,diseases, today ...,of EHA in Vienna, Austria, showed positive respon...treated with a new,radioimmunotherapy (RAIT) using...

...--Jun 11, 2007 - Geron,Corporation (Nasdaq:GERN) t...s indicating that GRNOPC1, the company,s human,emb...treatment of,spinal cord injury, evades a direct a...ron scientist Ross Okamura at the Federation of,Cl...the findings,could mean that patients treated with...

Other Medicine Technology:Fractionated Radioimmunotherapy With (90)Y-epratuzumab in,Non-Hodgkin's Lymphoma Appears Safe and Active in a Phase I/II,Study 2 Fractionated Radioimmunotherapy With (90)Y-epratuzumab in,Non-Hodgkin's Lymphoma Appears Safe and Active in a Phase I/II,Study 3 Fractionated Radioimmunotherapy With (90)Y-epratuzumab in,Non-Hodgkin's Lymphoma Appears Safe and Active in a Phase I/II,Study 4 Fractionated Radioimmunotherapy With (90)Y-epratuzumab in,Non-Hodgkin's Lymphoma Appears Safe and Active in a Phase I/II,Study 5 Research Indicates Geron's Human Embryonic Stem Cell-Based,Therapeutic for Spinal Cord Injury Evades Direct Attack by the,Human Immune System 2 Research Indicates Geron's Human Embryonic Stem Cell-Based,Therapeutic for Spinal Cord Injury Evades Direct Attack by the,Human Immune System 3

Fractionated Radioimmunotherapy With (90)Y-epratuzumab in,Non-Hodgkin's Lymphoma Appears Safe and Active in a Phase I/II,Study Research Indicates Geron's Human Embryonic Stem Cell-Based,Therapeutic for Spinal Cord Injury Evades Direct Attack by the,Human Immune System

...ference laboratory and a worldwide leader in innov...fers an extensive test menu of highly complex and ...ology. Owned by the University of Utah, ARUP Labor...ion's university teaching hospitals and children's...

Medicine Products:

Allergens, Inhalants, Midwest Comprehensive 2 Allergens, Inhalants, Environmental Profile 10 Allergens, Inhalants, Comprehensive Profile Allergens, Inhalants, California Environmental

Not All Colon Cancer Patients Need Chemother...(ancer. These are patients who sometimes ...),Health