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Not All Colon Cancer Patients Need Chemotherapy: Study
Date:5/16/2008

ancer. These are patients who sometimes get chemo and sometimes do not," Sargent said. "We have sought for a long time to try to determine if there was a way to predict which patients might benefit from chemo and which might not."

But, Sargent added, "we felt that in order to really recommend this in clinical practice, we needed to validate it."

The new study analyzed data from 1,027 patients in the United States as well as Canada, France and Italy who had participated in previous trials. Sixteen percent had dMMR.

"The goal was to validate that the 15 percent of patients who have defective mismatch repair did not receive any benefit from 5-FU therapy, and that is indeed exactly what we found," Sargent said.

"We now feel this is appropriately validated for clinical use," he added.

In fact, there is already a simple test for this type of cancer.

"The test is available and, in a patient with stage 2 disease being considered for treatment with chemotherapy, we think that this test would be useful," Sargent said.

More information

The National Cancer Institute has more on colon cancer.



SOURCES: Daniel Sargent, Ph.D., professor of biostatistics, Mayo Clinic, Rochester, Minn.; May 15, 2008, presentation, American Society of Clinical Oncology annual meeting, Chicago


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