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Nose-spray vaccine against botulism effective in first tests
Date:1/8/2009

n, all mice (8/8, or 100 percent) that received larger dose (2 107 pfu) of the BoNT/C-HC50 vaccine had survived by seven weeks after toxin challenge with no botulism symptoms, whereas none of the mice that received vector control without Hc50 survived. The protective immunity in mice could last for seven months after vaccination, researchers said.

Along with Zeng, the work was led in Rochester by Qingfu Xu, DVM, Ph.D., an instructor in the Department of Microbiology and Immunology at the University of Rochester School of Medicine and Dentistry. Lance Simpson, Ph.D., director of Center for Research on Bioterrorism and Biodefense at Thomas Jefferson University, Leonard Smith, Ph.D., chief of the Department of Molecular Biology, Integrated Toxicology Division at USAMRIID and Michael Pichichero, M.D., a partner at Legacy Pediatrics in Rochester, N.Y., were major contributors as well. The work was supported by the National Institute of Allergy and Infectious Diseases.

"We have demonstrated for the first time that a single, intranasal vaccination of an adenovirus-based vector encoding a humanized HC 50 of BoNT/C can provide full protection in vaccinated mice against botulinum neurotoxin type C," Zeng said. "We look forward to finalizing a vaccine, the most likely candidates for which would be active military and emergency responding personnel in forward areas."


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Contact: Greg Williams
Greg_Williams@urmc.rochester.edu
585-273-1757
University of Rochester Medical Center
Source:Eurekalert

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