Navigation Links
Norwegian brain researchers share Horwitz prize
Date:12/6/2013

Edvard and May-Britt Moser of the Norwegian University of Science and Technology (NTNU), and John O'Keefe, from University College London have been awarded the 2013 Louisa Gross Horwitz Prize for discoveries that have illuminated how the brain calculates location and navigation.

The Horwitz Prize is Columbia University's top honor for achievement in biology and biochemistry research. It is widely considered to be a precursor to a Nobel. Of the 91 Horwitz Prize winners to date, 43 have gone on to receive Nobel prizes.

The researchers' work, conducted in animal models, may lead to new treatments for Alzheimer's and other neurological disorders that affect the brain's spatial capabilities.

"How the brain records and recalls its trajectory through space is fundamental to understanding spatial memory," said Nobel laureate Eric R. Kandel, MD, who is University Professor & the Kavli Professor of Brain Science, co-director of the Mortimer B. Zuckerman Mind Brain Behavior Institute, and director of the Kavli Institute for Brain Science at Columbia University and senior investigator at the Howard Hughes Medical Institute.

"We are pleased to award our 2013 Horwitz Prize to Drs. Edvard Moser, May-Britt Moser, and John O'Keefe for the significant advancements they have made to the field of neuroscience," said Lee Goldman, MD, dean of the faculties of health sciences and medicine at Columbia University Medical Center and executive vice president for health and biomedical sciences at Columbia University.

Deeply honored

"We are deeply honored" said Edvard Moser. "The award recognizes the dedicated work and cooperation of many great scientists over several decades. It also highlights how basic science contributes pieces to solutions that yield cures for diseases."

"The Horwitz award is yet another acknowledgement of the scientific merits of May-Britt and Edvard Moser. Only the very best receive such an honor, and we at the Norwegian University of Science and Technology are very proud," said Stig Slrdahl, Dean of the Faculty of Medicine at the university.

"John O'Keefe's finding that part of the brain functions as a cognitive map was an important early milestone in the development of cognitive neuroscience, and the theoretical model of how the brain calculates its locationrefined by Edvard and May-Britt Moseris today a critical component of the study of hippocampal function," said Gerard Karsenty, MD, PhD, chair of the Horwitz Prize Committee and of the Department of Genetics and Development at Columbia University Medical Center.

"The contributions of these three scientists to neuroscience make them worthy recipients of the 2013 Horwitz Prize," said Michael Purdy, PhD, executive vice president for research, Columbia University. "Their theoretical insightsas well as the fact that John O'Keefe trained Edvard and May-Britt Moser in a research technique that became pivotal to their workconfirm the value of encouraging young scientists to connect with mentors in their field to learn technical skills and research strategies."

Computing cells

In 1971, Dr. O'Keefe discovered specific cells in the hippocampus that record location. These place cells, as they are called, register the locations of specific landmarks, such as the laboratory, or the corner deli. While recording the firing of neurons in rats as they moved from one location to another, he found that each location was logged by its own unique set of nerve cells in the CA1 region of the hippocampus, suggesting that the cells form a virtual map of the animal's location. The firing location of each cell was stable over time, and moving the animal to another location caused it to form a new map, using some of the same cells, in addition to new ones. When the animal was returned to its original location, it replayed the initial map that it had formed.

In 1996, Drs. Edvard Moser and May-Britt Moser, longtime collaborators who are married to each other, worked with Dr. O'Keefe, who became their mentor, to learn how to record the activity of cells in the hippocampus.

Nearly a decade later, in 2005, the Moser team discovered cells in the entorhinal cortex region in the brains of rats that function as a navigation system. These grid cells, as they are called, are responsible for the animals' knowing where they are, where they have been, and where they are going; they are constantly working to create a map of the outside world. Constructed in the nervous system from tactile, visual, and other sensory input, grid cells have provided fundamental insights into how spatial location and memory are computed in the brain. The mapping information flows from the entorhinal cortex to the hippocampus and then back, and scientists are now working to understand how the grid cells inform place cells, and vice versa.

Because the entorhinal cortex, which contains the grid cell navigation system, is often damaged in the early stages of Alzheimer's disease, the work by the Mosers and Dr. O'Keefe on how memory and cognitive ability are lost has great potential significance for Alzheimer's research. Scientists think that these findings may explain why getting lost is frequently an early sign of Alzheimer's and why memory fails as the disease progresses. Dr. O'Keefe's group has already shown that the place cells in a mouse model of dementia are less accurate at identifying the animal's location and that the magnitude of neuronal impairment correlates with deficits in spatial memory, as well as the amount of neuropathological amyloid plaque.


'/>"/>

Contact: Edvard Moser
edvard.moser@ntnu.no
47-930-54884
Norwegian University of Science and Technology
Source:Eurekalert  

Related medicine news :

1. ReNew Life Introduces Norwegian Gold® Krill Omega—an Advanced Krill and Fish Oil Formula with 2x More Omega-3 Per Softgel than the Leading Krill Oil Brand
2. ReNew Life Launches Norwegian Gold EPA 1000 Omega, the Highest Potency EPA-only Fish Oil Supplement Sold in Health Food Stores
3. Norwegian scientists win Perl-UNC Neuroscience Prize
4. The Chris Elliott Fund Announces Partnership with Coldwell Banker Bain Agents Anastasia Miles and Michele Schuler in the Fight to End Brain Cancer
5. State Farm Insurance Agent, Richele Brainin, Announces Holiday Shoe Drive for Soles4Souls
6. Penn study delivers protein across blood-brain barrier to degrade Alzheimers plaques
7. Brain cancer cells hide while drugs seek
8. Who is the culprit to cause memory impairment during brain aging?
9. C8 Sciences’ Activate Brain Training Program Receives Blue Ribbon Designation From IBCCES
10. Neuro-Oncology Pioneer Who Defined Standard of Care for Brain and Spinal Tumors Joins Capital Institute for Neurosciences
11. Parkinsons disease patients following subthalamic nucleus deep brain stimulation: fully understanding of social maladjustment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Norwegian brain researchers share Horwitz prize
(Date:7/22/2020)... ... July 22, 2020 , ... Healthcare data curation and ... Curation as a Service (DCaaS) solution for payers, providers, healthcare systems, and OEM ... curation parameters and are custom tailored to provide clients a clear, trusted, comprehensive ...
(Date:7/18/2020)... ... ... With government legislation stating that hospitality and retail businesses cannot open unless they ... visor, there has been a drastic increase in demand for PPE. However, with such ... in single-use plastic products being produced. , Due to the fear of transmission ...
(Date:7/18/2020)... (PRWEB) , ... July 18, 2020 , ... When the ... created a huge opportunity for small and some bigger businesses to obtain a PPP ... and members of the “GIG Economy” do not realize they are eligible. , ...
(Date:7/10/2020)... TROY, Mich. (PRWEB) , ... July 10, 2020 ... ... can be overwhelming for people with spinal cord disease or injury and social ... the COVID-19 pandemic can induce symptoms of anxiety, depression, distress, and PTSD amongst ...
(Date:7/10/2020)... PLEASANTON, Calif. (PRWEB) , ... July 10, 2020 ... ... (NYSE:TFX) focused on addressing unmet needs in the field of urology, today announced ... been designated as a UroLift® Center of Excellence. The designation recognizes that Dr. ...
Breaking Medicine News(10 mins):
(Date:7/7/2020)... Nova Scotia (PRWEB) , ... July 07, 2020 ... ... rebrand. Established in 2017, the company began as a hair service provider. Now ... both in-office and work-from-home employees. Bright’s expanded offering includes beauty amenities as well ...
(Date:7/2/2020)... ... July 02, 2020 , ... AllenComm, the leader in ... and four Omni Awards for visually compelling compliance training , onboarding , ... meet and exceed client and industry expectations as a digital transformation partner for learning ...
(Date:7/2/2020)... ... July 02, 2020 , ... Realty ... a four-part health series on its live agent Town Halls, furthering its commitment ... work. The series includes special guests and Realty ONE Group leadership discussing social, ...
Breaking Medicine Technology: