Navigation Links
Northwestern Memorial Successfully Completes Rare Four-Way Domino Paired Kidney Exchange Transplant Surgery
Date:4/8/2008

Four kidney donors and four recipients simultaneously underwent surgery

CHICAGO, April 8, 2008 /PRNewswire-USNewswire/ -- On Thursday, April 3, transplant surgeons at Northwestern Memorial Hospital successfully completed a rare procedure known as a four-way domino paired kidney exchange involving a total of eight patients. The surgery is among the nation's largest paired exchanges and involved four kidney donors and four recipients who underwent simultaneous transplant surgery. The donors were two women and two men, as were the recipients. All are recovering well following surgery, which involved a total of 32 clinicians -- six of them surgeons -- working between four operating rooms and took more than 10 hours to complete.

"This is a landmark surgery for our transplant team," said Joseph Leventhal, MD, PhD, transplant surgeon and director of the living donor kidney transplant program at Northwestern Memorial. "We are excited to have coordinated and successfully completed the region's first four-way exchange, and the largest paired exchange to ever occur at our hospital."

Northwestern Memorial's transplant team had previously performed what's known as a two-way paired exchange. This type of transplant is made possible when a kidney donor and their intended recipient are incompatible, but are matched with another donor and recipient in the same situation. But even paired kidney exchanges involving four patients are incredibly rare due to numerous compatibility requirements including blood type matching, tissue matching and crossmatching.

Events leading to last Thursday's "domino" exchange began to unfold when three transplant candidates came to Northwestern Memorial with donors, but all pairs discovered they were incompatible after testing. Simultaneous to these events, a Good Samaritan who always intended to be a living donor presented himself to the hospital's transplant program and offered one of his kidneys to whoever was in the greatest need. Unbeknownst to him, his act of kindness was the catalyst that set off a chain of compatibility for several recipients, because by adding a fourth transplant candidate who was at the top of the United Network for Organ Sharing (UNOS) organ recipient list the transplant team was able to arrange a four-way swap using a living donor matching system. In effect, all four recipients ultimately received compatible kidneys, but they were from donors they had never met.

"More than one-third of living kidney donor-recipient pairs are not compatible," said John Friedewald, MD, transplant nephrologist at Northwestern Memorial. "Paired exchange programs have the potential to dramatically increase the number of patients that receive transplants and reduce time spent on the waiting list."

Thursday's surgery crossed ethnic, gender, racial and language lines and brought together eight individuals that otherwise would never have met, but now are connected for life. Patients ranged in age from 25-65 years and hailed from Chicago and neighboring suburbs, Washington, D.C., and Puerto Rico.

"The diverse patient population that we transplanted in this four-way exchange speaks to the larger transplant community and the potential for individuals, regardless of background, to come together in order to donate life by helping others receive the organs they need," said Dr. Leventhal.

Doug Penrod, the Good Samaritan, or altruistic donor, is a Northwestern Memorial employee and 17-year member of the transplant team. He decided to donate his kidney blindly after his intentions to donate to a friend fell through. "After agreeing to donate my kidney once, and then not being able to, I felt I should still go through with the surgery and help out someone else in need," commented Penrod. "I've seen firsthand the good a transplant can do, and I know the risks to the donor are very minimal in both the short and long term. It was the right thing to do."

One of the recipients, Pierre Kattar Sr., reflected on his surgery, "After waiting so long, I'm thankful to have finally received a kidney." Kattar Sr. unsuccessfully tried to find a kidney match three times prior to Thursday's surgery. "Dialysis is draining, I felt washed out after every session and had no quality of life," he added.

Another recipient, Niral Patel, was incompatible with his donor due to a positive crossmatch. Northwestern Memorial is one of two hospitals in Illinois and only a handful nationwide that offer the capability to transplant ABO, blood type incompatible, or crossmatch incompatible donors and recipients. Transplant physicians desensitized Patel's blood before the transplant took place through a process called plasmapheresis, which cleans the antibodies in the blood so they do not attack the new kidney after the surgery. Patel went through several plasmapheresis treatments in the weeks preceding surgery, as well as additional treatments afterwards to ensure that the transplanted organ is not rejected. "I was able to find a kidney, and it took seven other people coming together to make this happen. It's clearly a miracle," commented Patel after the surgery.

"We are proud to have achieved this milestone and are committed to building our paired exchange program further," said Michael Abecassis, MD, MBA, chief of the division of organ transplantation at Northwestern Memorial Hospital. "These programs provide more options for those in need of a transplant, which means more lives saved."

About Northwestern Memorial Hospital

Northwestern Memorial Hospital is one of the country's premier academic medical centers and is the primary teaching hospital of the Northwestern University Feinberg School of Medicine. Northwestern Memorial and its Prentice Women's Hospital and Stone Institute of Psychiatry have 897 beds along with 1,424 affiliated physicians and 6,464 employees. Northwestern Memorial is recognized for providing state-of-the-art patient care and exemplary clinical and surgical advancements in the areas of cardiothoracic and vascular care, gastroenterology, neurology and neurosurgery, oncology, organ and bone marrow transplantation, and women's health.

Northwestern Memorial received the prestigious 2005 National Quality Health Care Award and is listed in eight specialties in U.S. News & World Report's 2007 rankings for "America's Best Hospitals." For seven years running, Northwestern Memorial has been rated among the nation's "100 Best Companies for Working Mothers" by Working Mother magazine and has been chosen by Chicagoans for more than a decade as their "most preferred hospital" according to the National Research Corporation's annual survey. Northwestern Memorial carries the Magnet status designation in nursing, the highest recognition possible for patient care and nursing excellence.


'/>"/>
SOURCE Northwestern Memorial Hospital
Copyright©2008 PR Newswire.
All rights reserved

Related medicine news :

1. Evanston-Northwestern Study Proves Effectiveness of MRSA Screening to Reduce Hospital Infections
2. Northwestern Memorial Hospital, CAPS, and p4ps Host Consumer Forum to Advance Partnerships to Improve Healthcare Patient Safety
3. Northwestern Mutual Is Americas Most Admired for an Unprecedented 25th Year
4. Lauren Debrauwere Released from Northwestern Memorial Hospital
5. Northwestern Memorial Hospitals Steven J. Stryker MD Unveils Campaign With Empower Public Relations
6. Northwestern Memorial HealthCare and Northwestern Memorial Foundation Elect New Members to Board of Directors
7. Northwestern Memorials Heart Center Pioneers Minimally Invasive Surgery That Corrects Irregular Heart Beat
8. Royalty Pharma Acquires a Portion of Northwestern Universitys Royalty Interest in Lyrica(R) for $700 Million
9. Northwestern University and ACORN Commence National Enrollment for Metastatic Breast Cancer Study
10. Northwestern exposing most deadly infectious diseases in 3-D
11. Northwestern Memorial Hospital Completes Move Into Its New Prentice Womens Hospital
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... December 08, 2016 , ... CURE Media Group, the nation’s leading ... has aligned with Upstage Lung Cancer in efforts to combat lung cancer, announced CURE ... Hennessy, Jr said, “CURE Media Group is honored to team up with Upstage Lung ...
(Date:12/8/2016)... , ... December 08, 2016 ... ... Suite 10.2 version gives development continuity to its innovative Unified Instance Manager ... management capacity. In addition, this new version optimizes the unattended auto-dialing system ...
(Date:12/8/2016)... ... December 08, 2016 , ... Today’s patients are encouraged to ... mind, SIGVARIS has created a new line of anti-embolism stockings to help prevent ... the benefits of graduated compression when transitioning from recovery to early rehabilitation. , ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... from offices headquartered in Jefferson County, is announcing the launch of a charity ... , The number of homeless women and children in Birmingham has grown steadily ...
(Date:12/8/2016)... ... December 08, 2016 , ... Bill Mull Agencies, a Wichita-based ... and around central Kansas, is joining the Youth Horizons organization for a charity ... Headquartered in Wichita, Youth Horizons works to empower area children from unstable, troubled, ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... A Small Business Innovative Research (SBIR) grant ... (NIH) to Phoenix -based NeuroEM Therapeutics, ... grant will seek to determine an optimal set of ... waves to treat Alzheimer,s Disease. The grant will also ... treat other neurologic disorders such as Parkinson,s Disease and ...
(Date:12/8/2016)... -- Economic growth in the United States will continue in ... in their December 2016 Semiannual Economic Forecast. Expectations are ... in mid-2009, as indicated in the monthly ISM ® ... manufacturing sector is optimistic about growth in 2017, with ... the non-manufacturing sector indicates that 14 of its industries ...
(Date:12/8/2016)... LOS ANGELES , Dec. 8, 2016 /PRNewswire/ ... and manufacturing of dissolution testing and diffusion testing ... has been acquired by Teledyne Instruments, Inc. ("Teledyne"). ... Hanson,s long-proven line of precision testing instruments, as ... while accelerating development of new products and services. ...
Breaking Medicine Technology: