Navigation Links
Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
Date:4/9/2012

Combining two strategies designed to improve the results of cancer treatment antiangiogenesis drugs and nanomedicines may only be successful if the smallest nanomedicines are used. A new study from Massachusetts General Hospital (MGH) researchers, appearing in Nature Nanotechnology, finds that normalizing blood vessels within tumors, which improves the delivery of standard chemotherapy drugs, can block the delivery of larger nanotherapy molecules.

"We found that vascular normalization only increases the delivery of the smallest nanomedicines to cancer cells," says Vikash P. Chauhan, of the Steele Laboratory of Tumor Biology in the MGH Radiation Oncology Department, lead author of the report. "We also showed that the smallest nanomedicines are inherently better than larger nanomedicines at penetrating tumors, suggesting that smaller nanomedicines may be ideal for cancer therapy."

Tumors need to generate their own blood supply to continue growing, but vessels supplying tumors tend to be disorganized, oversized and leaky. Not only does this prevent the delivery of chemotherapy drugs to cells not close to tumor vessels, but the leakage of plasma out of blood vessels increases pressure within the tumor, further reducing the ability of drugs to penetrate tumors. Treatment with drugs that inhibit angiogenesis the process by which new vessels are generated reduces some of these abnormalities, a process called vascular normalization that has been shown to improve treatment of some cancers with standard chemotherapy drugs.

Nanomedicines are actually designed to exploit tumor vessel abnormality. While the molecules of standard chemotherapy drugs are about one nanometer a billionth of a meter nanomedicine molecules are from 10 to 100 times larger, too large to penetrate the pores of blood vessels in normal tissues but small enough to pass through the oversized pores of tumor vessels. Since the size of nanomedicines should k
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Novel Method Eyed for Normalizing Blood Sugar
2. Improved Stem Cell Line May Avoid Tumor Risk: Study
3. Oxygen in tumors predicts prostate cancer recurrence
4. 2 targeted therapies act against Ewings sarcoma tumors
5. Freezing Secondary Breast Cancer Tumors Shows Promise
6. Cancer treatment system sculpts radiation beam to match shape of a tumor
7. How cancer cells start new tumor sites
8. Rare medical phenomenon of systemic tumor disappearance following local radiation treatment reported in a patient with metastatic melanoma
9. Study shows advance in using patients own tumor-fighting cells to knock back advanced melanoma
10. A culprit behind brain tumor resistance to therapy
11. Vitamin D shrinks fibroid tumors in rats
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/6/2015)... ... July 06, 2015 , ... ... 100% of all acids, chemicals and impurities; it also properly mineralizes the water ... it contains harmful contaminants.  These harmful contaminants are a byproduct of how the ...
(Date:7/6/2015)... ... July 06, 2015 , ... In ... medicine, the American Orthopaedic Society for Sports Medicine ( AOSSM ) will present ... Orlando, FL. As a leader in orthopaedic sports medicine, AOSSM annually provides ...
(Date:7/6/2015)... ... 06, 2015 , ... Acara Partners, a leading business team ... its complimentary educational webinar series for the summer of 2015. ... their clients through targeted marketing, sales, digital communications, branding and business development programs. ...
(Date:7/6/2015)... ... ... The Asian-Pacific market for rheumatoid arthritis therapeutics reached a value of more ... of over 3.2 percent in the years to come to hit the USD 6.9 ... an anticipated launch of a number of promising pipeline candidates and an increase in ...
(Date:7/6/2015)... ... ... doTERRA, the leading global essential oils company, is pleased to announce the ... position as Director of the Hinckley Institute at the University of Utah, a position ... states that he was ready for a new challenge, and out of many potential ...
Breaking Medicine News(10 mins):Health News:Pristine Water Filters.com Offers The 1st Water Revival System That Re-Mineralizes Drinking Water and Eliminates All Impurities and Chemicals 2Health News:American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting 2Health News:American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting 3Health News:American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting 4Health News:American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting 5Health News:American Orthopaedic Society for Sports Medicine (AOSSM) Presents Prestigious Research Awards at Annual Meeting 6Health News:Acara Partners Announces Complimentary Educational Webinar Series for Cosmetic Medical Practices and MedSpas 2Health News:Acara Partners Announces Complimentary Educational Webinar Series for Cosmetic Medical Practices and MedSpas 3Health News:APAC Rheumatoid Arthritis Therapeutics Market to Reach Value of USD 6.9 Billion by 2021, Says GBI Research in Its New Report Now Available at MarketPublishers.com 2Health News:doTERRA Welcomes Kirk Jowers to Its Executive Team 2Health News:doTERRA Welcomes Kirk Jowers to Its Executive Team 3Health News:doTERRA Welcomes Kirk Jowers to Its Executive Team 4
... CHICAGO, July 8 The Hispanic ... its 75 city tour, including the top 10,Hispanic cities, to ... The tour recently cruised through Chicago hosting free,events to encourage ... well,with nature,s wellness drink: milk. , ...
... ... Can Promote Prostate Health , ... Jacksonville, Fla. (Vocus) July 8, 2009 -- On June 30th, the ... effectiveness" research. Among the 100 different questions posed, high on the list was ...
... , WEDNESDAY, July 8 (HealthDay News) -- Though researchers aren,t ... longer, they hope a drug used to prevent rejection of ... , Middle-age mice that were given the drug rapamycin (Sirolimus) ... didn,t get the drug. , The findings, disclosed in a ...
... , WASHINGTON and EVANSTON, Ill., July 8 ... a data integration partnership facilitating integration of a ... SimCapture(R). SimCapture is an all-in-one solution for capturing, ... encounters. Mentice, manufacturer of the Mentice VIST(TM) endovascular ...
... patients rely on drugs to prevent graft rejection, ... The class of immunosuppressive drugs known as calcineurin ... patients, kidneys and lead to high blood pressure, ... can effectively replace calcineurin inhibitors in preventing graft ...
... SAN FRANCISCO, July 8 For the third ... one of the top medical groups in California as measured ... is the nation,s largest professional organization of physician groups practicing ... as being one of the best medical groups in California ...
Cached Medicine News:Health News:The Hispanic got milk? Campaign Visits Chicago from July 2 - July 10 2Health News:'Comparative Effectiveness' Research Addresses Options for Treating Prostate Cancer 2Health News:'Easter Island' Drug Adds Years to Mice 2Health News:B-Line Medical(R) and Mentice, Inc. Announce Data Integration Partnership 2Health News:B-Line Medical(R) and Mentice, Inc. Announce Data Integration Partnership 3Health News:Post-transplant combo can replace toxic immune-suppressing drugs in monkeys 2
(Date:7/6/2015)... 2015  OncoSec Medical Inc. ("OncoSec") (NASDAQ: ONCS ... announced the appointment of Joann V. Lofgren ... Market Development, effective July 6, 2015. In this role, ... executing on the company,s market and product development strategy ... to welcome Joann to the OncoSec team and have ...
(Date:7/5/2015)... TOKYO , July 6, 2015 ... first international symposium on Medical-Engineering Collaboration "Medicine ... on July 10, 2015 in Tokyo, ... or its medical applied research will present their ... technology and a new industry produced with 8K ...
(Date:7/4/2015)... Adding SIR-Spheres® Y-90 resin ... metastatic colorectal cancer in the liver (mCRC) further ... Patients with unresectable metastatic colorectal cancer (mCRC) that ... greatest improvement in Progression-Free Survival (PFS) in the ... microspheres to a current first-line chemotherapy regimen, according ...
Breaking Medicine Technology:OncoSec Medical Appoints Joann V. Lofgren as Vice President of Market Development 2OncoSec Medical Appoints Joann V. Lofgren as Vice President of Market Development 3Nihon University to Host International Symposium on Medical-Engineering Collaboration 2Nihon University to Host International Symposium on Medical-Engineering Collaboration 3New SIRFLOX Study Data Presented at World Congress of Gastrointestinal Cancer 2New SIRFLOX Study Data Presented at World Congress of Gastrointestinal Cancer 3New SIRFLOX Study Data Presented at World Congress of Gastrointestinal Cancer 4
... MATEO, Calif., Feb. 28, 2011 Nile Therapeutics, Inc. ... the development of novel therapeutics for heart failure patients, ... MDT ) on the clinical development of ... failure and renal disease applications. "We are ...
... 2011 Hotspur Technologies announced today that Dr. ... clinical use of its Keeper™ Embolectomy Catheter.  The ... within arteries, while also incorporating the capability of ... The Keeper Catheter combines a compliant ...
Cached Medicine Technology:Nile Therapeutics to Collaborate with Medtronic on Clinical Development of Cenderitide for Heart Failure and Renal Disease 2Nile Therapeutics to Collaborate with Medtronic on Clinical Development of Cenderitide for Heart Failure and Renal Disease 3Hotspur's Keeper Embolectomy Catheter Deployed for First Time 2
Round solid 15 mm wide lower plate. Open upper plate with inside diameter 12 mm. Serrated handle with locking thumb screw and polished finish....
Round solid 10 mm wide lower plate. Open upper plate with inside diameter 8 mm. Serrated handle with locking thumb screw and polished finish. Most popular size or model....
The popular E2002 Utrata Capsulorhexis Forceps with fine angled sharp tips. Angled 12 mm shafts with an iris stop. Flat handle with dull finish....
Fine angled tips ideal for grasping delicate capsule. Angled 12 mm shafts with iris stop allows ease of movement in the anterior chamber. Flat handle with dull finish. Manufactured in titanium....
Medicine Products: