Navigation Links
Normal weight obesity: An emerging risk factor for heart and metabolic problems
Date:3/27/2008

CHICAGO -- More than half of American adults considered to have normal body weight in America have high body fat percentages -- greater than 20 percent for men and 30 percent for women -- as well as heart and metabolic disturbances, new Mayo Clinic research shows. The finding conflicts with the widely held belief that maintaining a normal weight automatically guards against disorders such as high levels of circulating blood fats and a tendency to develop metabolic syndrome, which often leads to type 2 diabetes.

The researchers defined normal weight by body mass index (BMI). They found that people with normal BMI who had the highest percentage of body fat were also those who had metabolic disturbances linked to heart disease. The researchers use the phrase normal weight obesity to describe this new type of patient at risk for metabolism problems and risk factors for heart disease, but who rates as normal on standard weight charts. They defined normal weight obesity as a condition of having a normal BMI with high body fat percentage. The Mayo team will present its study results at the American College of Cardiologys Annual Scientific Session next week in Chicago.

Using the term normal weight obesity is really a way of being more precise about the changing conceptualization of obesity, because the real definition of obesity is excess body fat, says Francisco Lopez-Jimenez, M.D., a cardiologist on the Mayo research team. Our study demonstrates that even people with normal weight may have excessive body fat, and that these people are at risk for metabolic abnormalities that lead to diabetes and, eventually, to heart disease.

Significance of the Mayo Clinic Study

Heart disease remains the major cause of death and disability in westernized countries. Researchers around the world are striving to refine the relationship of body composition to heart health as a means of:

  • Designing more effective risk assessment tools

  • Improving public health programs for reducing risk

  • Designing new and better clinical rehabilitation programs for heart patients

While a focus on maintaining a healthy weight has long been a centerpiece of these efforts, Mayos new study suggests the focus may need to shift. Instead of tracking weight and BMI only, public health measures to prevent heart disease might benefit more from measuring the belly or by assessing percentage of body fat as more reliable risk factors of heart disease. Mayo studies in 2006 and 2007 suggested this criterion by demonstrating the inability of BMI to discriminate between body fat and lean muscle. Combined, the data from our earlier work and the current study suggest its time for a new measure of body fat as a risk factor of heart disease, says Dr. Lopez-Jimenez.

About the Study

The researchers studied 2,127 adults, equally divided between men and women, who had normal weight (BMI between 18.5 and 24.9 units). The participants body composition was assessed, and their risk factors for metabolic and heart disease were collected by the U.S. government in its Third National Health and Nutrition Examination Survey http://www.cdc.gov/nchs/products/elec_prods/subject/nhanes3.htm.

From this data, researchers found that normal weight obesity appears to be highly prevalent, affecting more than half of patients with a normal weight as defined by the BMI. After controlling for age, sex and race, normal weight obesity subjects had significantly higher rates of several alterations in blood chemistry that can negatively affect heart and metabolism health. These markers of disregulation include:

  • Altered blood lipid profile, such as cholesterol

  • High leptin, a hormone found in fat and other tissues and is involved in appetite regulation

  • Higher rates of metabolic syndrome


'/>"/>

Contact: Traci Klein
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Clinical depression linked to abnormal emotional brain circuits
2. Brain imaging reveals breakdown of normal emotional processing
3. Normal role for schizophrenia risk gene identified
4. Novadaq Resumes Normal Business Operations by Securing ICG for SPY
5. How Candida albicans transforms from its normally benign form into life-threatening form
6. Grant Supports Study of Abnormal Ring-Shaped Chromosomes
7. How shyness and other normal human traits became sickness
8. Key Cleaning Solutions Products Utilized to Combat Community Acquired - MRSA (CA-MRSA) Are Succeeding In Killing Superbugs Where Normal Cleaning Practices and Products Are Not
9. Normal tissue not spared in new forms of breast cancer radiotherapy
10. Abnormal immune cells may cause unprovoked anaphylaxis
11. Abnormal glutamine repeats interfere with key transcription factor, leading to neurodegeneration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2016)... ... December 05, 2016 , ... ... the company will provide alerting technology to Central Illinois Health Information Exchange ... million in federal funds as the sole sub-recipient participating with the Illinois ...
(Date:12/5/2016)... ... December 05, 2016 , ... BSI and Brenntag Canada have been appointed by ... distribution of their natural fruits and beverage colorants effective November 1, 2016. ... to our Life Sciences product portfolio,” said Steve Brauer, President of Brenntag Specialties, Inc. ...
(Date:12/5/2016)... (PRWEB) , ... December 05, 2016 , ... U.S. Apple ... nationwide as part of the second annual Apples for Education: Buy an Apple, ... food bank providing healthy food for students to take home to their families; solar ...
(Date:12/5/2016)... ... December 05, 2016 , ... Florida Hospital has named ... Florida Region. McGuinness brings experience in executive leadership and clinical practice, as well ... , In her new role, that officially begins December 12, 2016, she will ...
(Date:12/5/2016)... ... December 05, 2016 , ... “Life Will Never Be The ... family and friends. “Life Will Never Be The Same” is the creation of published ... writing children's books and holds a degree in Christian religion and philosophy from Judson ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... Health and Gateway Health proudly announce a dynamic collaboration that ... plan members with specific high risk needs. In ... group of consumers, Wellbridge combines technology and population expertise with ... members, daily behaviors and lifestyle. ... , , ...
(Date:12/5/2016)... , Dec. 5, 2016  New research ... ) Research Institute and the U.S. Department of ... Secretary for Preparedness and Response (ASPR), published online ... that automated pharmacy notifications encourage patients with chronic ... natural disaster. The study also affirms that public-private ...
(Date:12/5/2016)...  BD (Becton, Dickinson and Company) (NYSE: ... demonstrate an enhanced technology platform designed with the ability ... leading Pyxis™ and Alaris™ systems, at this year,s ... being held in Las Vegas ... show that approximately 68 percent of medication errors occur ...
Breaking Medicine Technology: