Navigation Links
Normal Cells May Predict Cancer Virulence
Date:8/28/2008

witch on different cancer genes.

Podsypanina and her colleagues performed a series of experiments in mice.

First, they injected normal mammary cells that contained cancer-inducing oncogenes, which could be switched on and off. These cells migrated through the bloodstream to the lungs, residing there for four months. They did not begin to grow aggressively until the oncogenes had been turned on, but they did so without first going through the stage of being a primary tumor.

Next, they injected normal cells without manipulating any oncogenes.

"Cells that did not have any oncogenes in them and do not transform spontaneously as per all published studies, we could see little colonies of these cells when we inspected the lungs," Podsypanina said. "At no point, never, did we see a solid vision that would resemble metastatic colonies, [but] it appears that every time we looked at the animal, the colonies appeared to be larger."

When these normal ectopic cells were injected back into a new generation of mice, they developed into normal mammary glands.

"It's a beginning," Podsypanina said. "It's an important step to show whether or not the first step of the metastatic cascade is something a normal cell can accomplish."

More information

Visit the American Cancer Society for more on oncogenes.



SOURCES: Katrina Podsypanina, M.D., Ph.D., senior research scientist, department of cancer biology and genetics, Memorial Sloan-Kettering Cancer Center, New York City; Claudine Isaacs, M.D., director, clinical breast cancer program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C.; Aug. 28, 2008, Science


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Clinical depression linked to abnormal emotional brain circuits
2. Brain imaging reveals breakdown of normal emotional processing
3. Normal role for schizophrenia risk gene identified
4. Novadaq Resumes Normal Business Operations by Securing ICG for SPY
5. How Candida albicans transforms from its normally benign form into life-threatening form
6. Grant Supports Study of Abnormal Ring-Shaped Chromosomes
7. How shyness and other normal human traits became sickness
8. Key Cleaning Solutions Products Utilized to Combat Community Acquired - MRSA (CA-MRSA) Are Succeeding In Killing Superbugs Where Normal Cleaning Practices and Products Are Not
9. Normal tissue not spared in new forms of breast cancer radiotherapy
10. Abnormal immune cells may cause unprovoked anaphylaxis
11. Abnormal glutamine repeats interfere with key transcription factor, leading to neurodegeneration
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Normal Cells May Predict Cancer Virulence
(Date:4/25/2015)... 2015 The URO CENTER of NEW YORK ... chosen by the New York Academy of Medicine to receive ... the field of Urology. , Dr. Ferdinand Valentine, born in ... diseases. He was a man of rare and attractive ... Not only did he devote his life to his ...
(Date:4/25/2015)... (PRWEB) April 25, 2015 On Friday, ... of RFID Journal’s annual Best Implementation Award. This ... demonstrated the best use of RFID technology to improve ... is the company that best demonstrates how RFID is ... presented at RFID Journal Live! 2015 in San Diego, ...
(Date:4/24/2015)... 2015 Bird B Gone, the leader in ... offers a complete line of bird control solutions to address ... New Flu Strains Threaten Pacific, Central and Mississippi Farms , ... , a number of highly pathogenic avian flus in the ... often spread when wild birds enter poultry farms. The USDA ...
(Date:4/24/2015)... Will County, Illinois (PRWEB) April 24, 2015 ... 2015 event includes septic tank pumping ( http://www.zeitersseptics.com/multi-customer-discount.html ) ... of 3-customers to start the program. This does not ... may be applicable. Save $25-$65 per person. If someone ... Aerobic/Mechanical unit, or two tanks totaling approximately 2500 gallons ...
(Date:4/24/2015)... Ranch, California (PRWEB) April 24, 2015 ... has a wide range of capabilities and services to ... , Ryadon's Quantity Discount Program will be offered ... as follows: , Order 4-19: Receive 10% discount - ... Benefit by Using the Drawer Slides Products, ...
Breaking Medicine News(10 mins):Health News:The 2015 Valentine Award Comes From The Heart and Goes To Famous New York Urologist 2Health News:The 2015 Valentine Award Comes From The Heart and Goes To Famous New York Urologist 3Health News:Seeonic’s Industry Leading Technology Powers Interstate Batteries to Winning Award 2Health News:Bird B Gone Offers Solutions to Bird Flu Threat to Poultry Farms 2Health News:Bird B Gone Offers Solutions to Bird Flu Threat to Poultry Farms 3Health News:Bird B Gone Offers Solutions to Bird Flu Threat to Poultry Farms 4Health News:Zeiter's Septics Inc. Offers Multi Customer Septic Tank Cleaning Program in Cook, Putnam & Will Counties in May 2015 2Health News:Zeiter's Septics Inc. Offers Multi Customer Septic Tank Cleaning Program in Cook, Putnam & Will Counties in May 2015 3Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 2Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 3
... Reporter , TUESDAY, Feb. 28 (HealthDay News) -- While ... boost your immune function and lower your risk of death, ... levels of selenium may contribute to the development of type ... of evidence finds. "There is a U-shaped relationship ...
... with diabetes could be adapted into a home DNA detector ... bacteria in human body fluids, in food and in other ... on this adaptation of the ubiquitous personal glucose monitor, typically ... Analytical Chemistry . Yi Lu and Yu Xiang ...
... This release is available in French . ... of Montreal and CHUM Hospital,s International Health, will be joining ... working on the funding of the fight against Noma. This ... children mostly in Sub-Saharan Africa. Despite the existence of a ...
... Feb. 28 (HealthDay News) -- Even when fast-food restaurants list ... hard time using the information to make healthy meal choices, ... the calorie listings for 200 food items on menu boards ... of Harlem. Too often, calorie counts were listed for ...
... HealthDay Reporter , TUESDAY, Feb. 28 (HealthDay News) -- ... adults or children to its aftereffects, Canadian researchers report. ... is essential for reading and calculating, and those effects ... authors found. "Contrary to the belief by some ...
... Reporter , TUESDAY, Feb. 28 (HealthDay News) -- Menstrual cramps are ... form of vitamin D may one day be added to the ... A small study in Italy found that a single, high dose ... to a marked reduction in menstrual cramps, with the largest benefits ...
Cached Medicine News:Health News:Selenium Supplements May Help -- or Harm 2Health News:Selenium Supplements May Help -- or Harm 3Health News:Montrealer heads to Congo to fight childhood disfigurement 2Health News:Many Gaps in Fast-Food Nutrition Information 2Health News:Teens May Fare Worse After Concussion Than Children or Adults 2Health News:Teens May Fare Worse After Concussion Than Children or Adults 3Health News:Vitamin D3 Might Ease Menstrual Cramps 2Health News:Vitamin D3 Might Ease Menstrual Cramps 3
(Date:4/24/2015)... Allowing more basic emergency medical service (EMS) staff to ... opioids, according to a Centers for Disease Control and ... Medical Service Providers and the Burden of Drug Overdose ... of Public Health . In 2013, more ... involved prescription opioids, and more than 8,000 ...
(Date:4/24/2015)... 24, 2015  A new study shows an "alarming rise" ... used to slow the progression of multiple sclerosis or reduce ... researchers at Oregon Health & Science University (OHSU) and Oregon ... number of MS drugs in the marketplace over the past ... costs for patients who use those drugs. Researchers found the ...
(Date:4/24/2015)... 2015  New technologies and online platforms have ... themselves about products and companies. Likewise, these same ... to market researchers seeking insights into consumer behavior. ... imperative that organizations adjust their consumer marketing playbook ... niches and growth fronts. To ...
Breaking Medicine Technology:Expanding Naloxone use could reduce drug overdose deaths and save lives 2Expanding Naloxone use could reduce drug overdose deaths and save lives 3Researchers find alarming rise in cost of MS drugs over past two decades 2Researchers find alarming rise in cost of MS drugs over past two decades 3Researchers find alarming rise in cost of MS drugs over past two decades 4Pharmaceutical Industry Using New Technologies to Adjust Their Marketing and Research Approaches for Consumers 2
... While much has been reported about an end to ... being felt in the veterinary community.  Fifty-one percent of veterinarians ... two years, while 42 percent said that revenues decreased in ... that has been documented over the last decade, even while ...
... Medical, Inc. (OTCBB: HASC), www.mysouthernmed.com , a managed ... Mississippi, announced the launch of a newly redesigned  web ... Vans of America ( www.WCvans.com ). ... more customer friendly.   MobilityFreedom.com now provides an ...
Cached Medicine Technology:Bayer Study Reveals Gaps in Perception of Veterinary Care Between Vets and Pet Owners 2Bayer Study Reveals Gaps in Perception of Veterinary Care Between Vets and Pet Owners 3Bayer Study Reveals Gaps in Perception of Veterinary Care Between Vets and Pet Owners 4Bayer Study Reveals Gaps in Perception of Veterinary Care Between Vets and Pet Owners 5HASCO Medical Announces New Redesigned Websites for Mobility Freedom and Wheelchair Vans of America 2
... Deluxe Transport beds feature folding head end and foot ... With the head end and foot end deck panels ... to approximately 67". This compact length makes storage, delivery ... ,This feature is not available on Model 4748B, Basic ...
... safety. Patient dignity. A single solution., ... to provide added safety where its needed. ... to help protect the caregiver and patient ... bed functions just like other TotalCare® beds, ...
... 1000ML 0.45% Sodium Chloride ... performance and ease of use. You can obtain ... to 100% FIO 2 . We offer a ... USP; 0.45% sodium chloride inhalation, USP; and 0.9% ...
... Sterile H 2 O W/O Adapter., ... inhalation, these humidifier systems feature a dual-purpose reservoir ... opening for secure attachment of a humidifier adapter. ... particulate from reaching oxygen delivery tubing. An audible ...
Medicine Products: