Navigation Links
Nontoxic nanoparticle can deliver and track drugs
Date:11/18/2008

own to inhibit cell growth associated with vascular disease.

Several drugs have been shown in cultures to be promising for reducing hardening of the arteries and narrowing of blood vessels after balloon angioplasty. The problem has been in delivering any of these drugs to a target, Butler says.

Ceramide, a chemotherapeutic molecule that initiates cell death in cancer cells, has the ability to slow growth in healthy cells.

Mark Kester, professor of pharmacology, and Jong Yun, associate professor of pharmacology, both at Penn State College of Medicine, have optimized ceramide for both cancer and vascular disease.

Their groups found that by using human vascular smooth muscle cells in vitro, ceramide encapsulated in calcium phosphate nanoparticles reduced growth of muscle cells by up to 80 percent at a dose 25 times lower than ceramide administered freely, without damaging the cells.

The calcium phosphate nanoparticles were developed by James Adair, professor of materials science and engineering, and his students. The nanoparticles have several benefits other drug delivery systems do not, according to lead author Thomas Morgan, graduate student in chemistry.

Unlike quantum dots, which are composed of toxic metals, calcium phosphate is a safe, naturally occurring mineral that already is present in substantial amounts in the bloodstream.

"What distinguishes our method are smaller particles (for uptake into cells), no agglomeration (particles are dispersed evenly in solution), and that we put drugs or dyes inside the particle where they are protected, rather than on the surface," says Morgan. "For reasons we don't yet understand, fluorescent dyes encapsulated within our nanoparticles are four times brighter than free dyes.

"Drugs and dyes are expensive," he continues, "but an advantage of encapsulation is that you need much less of them. We can make high concentrations in the lab, and dilute them way down and still be effective. We eve
'/>"/>

Contact: A'ndrea Elyse Messer
aem1@psu.edu
814-865-9481
Penn State
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Nanoparticles trigger cell death?
2. Consumers Union Urges FDA to Conduct Full Scale Safety Review of Nanoparticles in Sunscreen
3. Researchers use nanoparticles to deliver treatment for brain, spinal cord injuries
4. New disease-fighting nanoparticles look like miniature pastries
5. Nanoparticles + light = dead tumor cells
6. Using magenetic nanoparticles to combat cancer
7. Nanoparticle Stops Cancer From Spreading
8. Smart bomb nanoparticle strategy impacts metastasis
9. Nanoparticles aid bone growth
10. Magnetic nanoparticles: Suitable for cancer therapy?
11. Brown chemists create cancer-detecting nanoparticles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... Plugin and template developers from Pixel ... for Final Cut Pro X. , “TransPack Volume 5 gives ... pull off an industry professional look” Said Christina Austin, CEO ... TransPack Volume 5, a new level of professionalism will become ... over 50 Final Cut Pro X transitions featuring organic animations. ...
(Date:12/26/2014)... December 26, 2014 DW-InductionHeating.com (DaWei Induction ... designing, researching and developing, producing and marketing of a ... the business announces their new series of induction ... of the company, induction brazing refers to ... special filler material and heat. The manager says that ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 “Every three months the trends for ... sweetheart evening dress will be one of the hottest styles ... Yunx.co.uk says. Today, the company releases 26 A-line sweetheart evening ... 80% off. , “We are trying our best to ... our latest designs. Along with affordable prices, we provide discounted ...
(Date:12/25/2014)... 2014 Recently, BellasDress has ... its wedding dresses. BellasDress has chosen their best-selling lace ... choices for the holiday season. , Now, BellasDress.com ... wedding gowns here at discount prices. The business hopes ... its website. , “All our elegant products ...
Breaking Medicine News(10 mins):Health News:Today a new plugin was announced from Pixel Film Studios, TransPack Volume 5 for Final Cut Pro X 2Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2
... suggests that a urine test can help in both ... raises the possibility of treating these with anti-angiogenesis drugs ... Pediatrics, has published an article about vascular anomalies in ... of newly born infants and include both vascular malformations ...
... gambling behavior may share their personality// profiles with substance ... been able to identify personality traits of problem gambling ... those of substance abusers. Researchers in their research have ... problem gambling behavior may not represent the entire gamut ...
... recent research paper on chronic obstructive pulmonary disease ... useful for patients of this disease to have ... pulmonary disease (COPD) are lung diseases involving restricted ... inflammation, air sac enlargement etc. some common forms ...
... that it will promote a culture of openness and ... vision, FDA will create a new independent Drug Safety ... issues, and will provide emerging information to health providers ... ,Specific proposals for immediate and fundamental steps to ...
... journal Epidemiology has published a major retrospective study that indicates ... is associated infertility. ,Dr. Louise A. Brinton, of ... 12,193 U.S. women treated for infertility between 1965 and ... of the general population. The women were followed for a ...
... a short term a single drug may be used to ... ,Bipolar disorder is a psychotic disorder characterized by successive feelings ... affects 3 to 4 5 of the global adult population. ... have multiple occurrences of the condition for most of their ...
Cached Medicine News:Health News:Simple Urine Test Can Help To Monitor Disfiguring Birthmarks, 2Health News:Monitoring Drug Safety 2
(Date:12/24/2014)... 2014   Assurex Health, a personalized medicine ... providers for behavioral health and chronic pain conditions, ... in equity financing from new and existing investors, ... and Chief Executive Officer. The financing ... Assurex Health,s GeneSight ®  products.  GeneSight,s ...
(Date:12/24/2014)... Tianyin Pharmaceutical Co., Inc. (NYSE MKT: ... biopharmaceutical, modernized traditional Chinese medicine (mTCM), branded generics ... the Company achieved the Public Notice (Gong Shi) ... of TPI,s Qionglai Facility (QLF) from the China ... period is a significant procedure of GMP certification ...
(Date:12/24/2014)... 23, 2014  Medical Science Liaisons play a large ... between the medical device industry and key stakeholders, the ... coming years as the device industry relies on them ... research by benchmarking firm, Best Practices, LLC, one area ... edge is by harnessing new technology to enable education. ...
Breaking Medicine Technology:Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4TPI QLF Achieved Public Notice Status of GMP Certification 2TPI QLF Achieved Public Notice Status of GMP Certification 3Role of Medical Science Liaisons Evolving in Medical Device Sector 2
... RICHMOND, Va., Feb. 5 Insmed Inc. (Nasdaq:,INSM), ... that it has launched a broad education campaign ... the U.S. for large molecule,protein-based drugs, known as ... as biosimilars or biogenerics., The scientific, regulatory, ...
... MOUNTAIN VIEW, Calif., Feb. 5 Alexza,Pharmaceuticals, Inc. ... has initiated,a Phase 1 clinical trial with AZ-007 ... developed for the treatment of insomnia,patients who have ... middle of the night and have difficulty falling ...
Cached Medicine Technology:Insmed Launches National Awareness Campaign Surrounding Follow-On Biologics 2Insmed Launches National Awareness Campaign Surrounding Follow-On Biologics 3Alexza Initiates AZ-007 (Staccato(R) Zaleplon) Phase 1 Clinical Trial and Updates Clinical Pipeline Development Status 2Alexza Initiates AZ-007 (Staccato(R) Zaleplon) Phase 1 Clinical Trial and Updates Clinical Pipeline Development Status 3Alexza Initiates AZ-007 (Staccato(R) Zaleplon) Phase 1 Clinical Trial and Updates Clinical Pipeline Development Status 4Alexza Initiates AZ-007 (Staccato(R) Zaleplon) Phase 1 Clinical Trial and Updates Clinical Pipeline Development Status 5Alexza Initiates AZ-007 (Staccato(R) Zaleplon) Phase 1 Clinical Trial and Updates Clinical Pipeline Development Status 6Alexza Initiates AZ-007 (Staccato(R) Zaleplon) Phase 1 Clinical Trial and Updates Clinical Pipeline Development Status 7
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: