Navigation Links
Noninvasive liver tests may predict hepatitis C patient survival

Non-invasive tests for liver fibrosis, such as liver stiffness measurement or the FibroTest, can predict survival of patients with chronic hepatitis C, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute.

"Liver stiffness measurement and/or the FibroTest could replace liver biopsy for the evaluation of hepatitis C, regardless of the stage of the disease," said Victor de Ldinghen, MD, PhD, of the Centre d' Investigation de la Fibrose Hpatique and lead author of this study. "Thus, these tools may help physicians assess prognosis early and discuss specific treatments."

Findings of this study are of major importance since liver stiffness, as a good predictive factor of survival, may help physicians evaluate the severity of liver disease earlier, decide with stronger arguments on a liver transplant or a portosystemic shunt (to bypass the liver), and evaluate more precisely the surgical risk of cirrhotic patients.

In chronic liver diseases, fibrosis assessment predicts liver-related complications and survival. In this study, doctors evaluated the five-year prognostic value of liver stiffness, non-invasive tests of liver fibrosis and liver biopsy to predict overall survival and survival without liver-related death in chronic hepatitis C.

A total of 1,457 patients with chronic hepatitis C were included. At five years, 77 patients died (39 liver-related deaths) and 16 patients had liver transplantation. Overall survival was 91.7 percent and survival without liver-related death was 94.4 percent. Survival was significantly decreased in patients diagnosed with severe fibrosis, no matter which non-invasive method was used.

All methods were able to predict shorter survival times; liver stiffness measurement and results of the FibroTest had higher predictive values. Doctors assessed fibrosis and on the same day liver stiffness, performed noninvasive tests of fibrosis (FibroTest, the aspartate aminotransferase to platelet ratio index, FIB-4), and analyzed liver biopsy samples.

"To our knowledge, this study is the first showing that liver stiffness has a prognostic value for overall survival and survival without liver-related death in patients with chronic hepatitis C virus infection," added Dr. Ldinghen. "The present study independently validated the prognostic value of the FibroTest and showed that liver stiffness and FibroTest can predict survival."


Contact: Alissa J. Cruz
American Gastroenterological Association

Related medicine news :

1. Noninvasive diagnostics may offer alternative to liver biopsy for assessing liver fibrosis
2. Mayo Clinic reports new findings on noninvasive test for pancreatic cancer
3. GEN reports on novel noninvasive tests for early cancer detection
4. Noninvasive extenders are better than surgery for men who want a longer penis
5. Noninvasive Test May Identify Down Syndrome Early On
6. Noninvasive test for trisomy 21 closer at hand
7. Noninvasive Glaucoma Test Might Speed Up Detection
8. Noninvasive brain stimulation helps improve motor function in stroke patients
9. Noninvasive Test for Colon Cancer Shows Promise in Early Trial
10. Prediction tool helps estimate local recurrence in patients with noninvasive breast cancer
11. Noninvasive combination technique may reduce number of breast biopsies
Post Your Comments:
(Date:10/13/2015)... ... October 13, 2015 , ... Altec Products, ... Title Sponsorship of Synergy 2015. The annual WennSoft KEY2ACT user conference will take ... and will unite customers, partners, WennSoft team members and sponsors to facilitate the ...
(Date:10/13/2015)... ... , ... Tempe Dental Care, a leading Tempe dentists’ office, celebrates offering gentle, ... for more than 5 years. A leading cause of emergency room visits, school ... is not timely. , Sedation dentistry provides an anxiety-free dental experience ...
(Date:10/13/2015)... , ... October 13, 2015 , ... ... activities. Yet most people do not breathe correctly. According to T’ai Chi (also ... Steve Lauer, learning to breathe correctly, in concert with the 7,000 year old ...
(Date:10/13/2015)... , ... October 13, 2015 , ... ... communities, and the Florida Apartment Association (FAA) has partnered with the Florida Department ... meet the demand. , The FAA Smoke-Free Multifamily Housing Program launched last ...
(Date:10/13/2015)... ... , ... Curly Hair Solutions® is thrilled to be a ... featuring the newest products and services to hit the market for women. With ... to unveil their recent partnership with Trade Secrets, a leading Canadian beauty retailer. ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... LONDON , Oct. 12, 2015 ... eye, it is quite challenging to deliver an ophthalmic drug ... be overcome for a successful ocular drug delivery. These include ... by the lymphatic system of conjunctiva and drug permeation issues ... of the drug, in topical eye drops, is lost due ...
(Date:10/12/2015)... Oct. 12, 2015  The Pharmacy Compounding Accreditation ... Compounding Pharmacy in Costa Mesa ... of the pharmacy,s commitment to meeting and/or exceeding ... --> --> ... --> --> Harbor ...
(Date:10/12/2015)... 2015  MiMedx Group, Inc. (NASDAQ: MDXG ), ... and patent-protected processes to develop and market advanced products ... Sports Medicine, Ophthalmic, and the Dental sectors of healthcare, ... quarter of 2015, its guidance for the fourth quarter ... $50 million Senior Secured Credit Facility. ...
Breaking Medicine Technology: