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Noninvasive combination technique may reduce number of breast biopsies
Date:6/21/2010

e ultrasound locates the lesion, DOT is performed by shining infrared light into the area and measuring light absorption at two optical wavelengths.

"Infrared light penetrates deep into tissue, up to four centimeters," Dr. Zhu said.

Researchers computed total hemoglobin levels from the light absorption measured at two wavelengths and correlated the measurements with biopsy results. Laboratory examination of tissue samples revealed two in situ carcinomas, 35 carcinomas that measured less than two centimeters, 24 carcinomas greater than two centimeters and 114 benign lesions.

"Both maximum and average total hemoglobin levels were significantly higher in the malignant groups than in the benign group," Dr. Zhu said.

The sensitivity and specificity of the technique (92 percent and 93 percent, respectively) were greatest when evaluating cancers less than two centimeters in size.

"Based on our results, we believe that ultrasound-guided diffuse optical tomography holds promise as an adjunct to diagnostic mammography and ultrasound for distinguishing early-stage invasive breast cancers from benign lesions," Dr. Zhu said. "We expect this technology will be used to help radiologists evaluate small to intermediate size lesions that are harder to diagnose with conventional imaging technologies."

Ultrasound and near infrared procedures cost significantly less than magnetic resonance imaging (MRI), another technique used to evaluate suspicious breast lesions that cannot be diagnosed using mammography.

The next step in Dr. Zhu's research, which is supported by grants totaling $1.4 million from the National Institutes of Health with additional $600,000 support from the Donaghue Medical Research Foundation, is to design multi-institution clinical trials for ultrasound-guided DOT.


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Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

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