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Noninvasive colorectal cancer screening tool shows unprecedented detection rates
Date:3/19/2014

at greatest risk to progress to cancer (i.e., those containing high-grade dysplasia).

  • Cologuard detected significantly more cancers and significantly more precancerous polyps than did FIT.

    "The most important finding of the study is the high sensitivity of Cologuard for curable stage colorectal cancer, which represents the highest sensitivity of any noninvasive test to date," says Thomas Imperiale, M.D., a Professor of Medicine at Indiana University Medical Center in Indianapolis and a study author. "It is also significant to note that these results were achieved in a robustly conducted multicenter study."

    Colorectal cancer is often considered the most preventable, yet least prevented, cancer. Nearly 50 percent of adults age 50 and older have not been screened as recommended and, as a result, colorectal cancer has become the second-leading cause of cancer death in the United States. Colorectal cancer is highly treatable if found early, and it is preventable if the precancerous polyps at greatest risk of progressing can be detected.

    "Dr. Ahlquist's work exemplifies our goal at Mayo Clinic, which is the relentless pursuit of innovation aimed to help our patients. This research will transform how we think about colorectal cancer screening going forward," says Vijay Shah, M.D., chair of Mayo Clinic's Division of Gastroenterology and Hepatology.

    Cologuard works by testing a patient's stool for altered DNA shed during digestion. Altered DNA is known to occur within colorectal cancers and precancerous polyps. The test also examines the stool for the presence of blood, another possible indicator of colorectal cancer. Combining the data from the stool DNA test and the blood test into a single result provides a comprehensive, powerful screening approach, which is reflected in the study results.

    Because of its accessibility and ease of use, researchers hope the test will increase the number of people who will choos
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  • Contact: Brian Kilen
    newsbureau@mayo.edu
    507-284-5005
    Mayo Clinic
    Source:Eurekalert

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