Navigation Links
Non-invasive mapping helps to localize language centers before brain surgery
Date:4/8/2013

Philadelphia, Pa. (April 8, 2013) A new functional magnetic resonance imaging (fMRI) technique may provide neurosurgeons with a non-invasive tool to help in mapping critical areas of the brain before surgery, reports a study in the April issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

Evaluating brain fMRI responses to a "single, short auditory language task" can reliably localize critical language areas of the brainin healthy people as well as patients requiring brain surgery for epilepsy or tumors, according to the new research by Melanie Genetti, PhD, and colleagues of Geneva University Hospitals, Switzerland.

Brief fMRI Task for Functional Brain Mapping

The researchers designed and evaluated a quick and simple fMRI task for use in functional brain mapping. Functional MRI can show brain activity in response to stimuli (in contrast to conventional brain MRI, which shows anatomy only). Before neurosurgery for severe epilepsy or brain tumors, functional brain mapping provides essential information on the location of critical brain areas governing speech and other functions.

The standard approach to brain mapping is direct electrocortical stimulation (ECS)recording brain activity from electrodes placed on the brain surface. However, this requires several hours of testing and may not be applicable in all patients. Previous studies have compared fMRI techniques with ECS, but mainly for determining the side of language function (lateralization) rather than the precise location (localization).

The new fMRI task was developed and evaluated in 28 healthy volunteers and in 35 patients undergoing surgery for brain tumors or epilepsy. The test used a brief (eight minutes) auditory language stimulus in which the patients heard a series of sense and nonsense sentences.

Functional MRI scans were obtained to localize the brain areas activated by the language taskactivated areas would "light up," reflecting increased oxygenation. A subgroup of patients also underwent ECS, the results of which were compared to fMRI.

Non-invasive Test Accurately Localizes Critical Brain Areas

Based on responses to the language stimulus, fMRI showed activation of the anterior and posterior (front and rear) language areas of the brain in about 90 percent of subjectsneurosurgery patients as well as healthy volunteers. Functional MRI activation was weaker and the language centers more spread-out in the patient group. These differences may have reflected brain adaptations to slow-growing tumors or longstanding epilepsy.

Five of the epilepsy patients also underwent ECS using brain electrodes, the results of which agreed well with the fMRI findings. Two patients had temporary problems with language function after surgery. In both cases, the deficits were related to surgery or complications (bleeding) in the language area identified by fMRI.

Functional brain mapping is important for planning for complex neurosurgery procedures. It provides a guide for the neurosurgeon to navigate safely to the tumor or other diseased area, while avoiding damage to critical areas of the brain. An accurate, non-invasive approach to brain mapping would provide a valuable alternative to the time-consuming ECS procedure.

"The proposed fast fMRI language protocol reliably localized the most relevant language areas in individual subjects," Dr. Genetti and colleagues conclude. In its current state, the new test probably isn't suitable as the only approach to planning surgerytoo many areas "light up" with fMRI, which may limit the surgeon's ability to perform more extensive surgery with necessary confidence. The researchers add, "Rather than a substitute, our current fMRI protocol can be considered as a valuable complementary tool that can reliably guide ECS in the surgical planning of epileptogenic foci and of brain tumors."


'/>"/>

Contact: Connie Hughes
connie.hughes@wolterskluwer.com
646-674-6348
Wolters Kluwer Health
Source:Eurekalert

Related medicine news :

1. Non-invasive treatment for children with obstructive sleep apnea suggested by Ben-Gurion University study
2. Non-invasive diagnostic imaging costs to Medicare Part B down significantly since 2006
3. Illy Trieste Science Prize: Yuk Ming Dennis Lo awarded for non-invasive prenatal diagnosis
4. NHS should replace traditional autopsies with non-invasive alternative
5. Researchers develop non-invasive technique for predicting patients response to chemotherapy
6. From bullying to relationships: Mapping our online communications
7. 'LKLiveMapping' Improves Laboratory Operating Efficiency, Delivers a High First-Submission Approval of Claims, and Improves Collection
8. Engineering the future of health care -- from brain mapping to smarter limb prostheses
9. Public lecture at UC Riverside to address brain-mapping project
10. Brain mapping reveals neurological basis of decision-making in rats
11. Researchers decode biology of blood and iron disorders mapping out novel future therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... Caloifornia (PRWEB) , ... December 07, 2016 , ... ... present the fifth annual Business Architecture Innovation Summit in Reston, VA on March ... world who will share a range of experiences from a cross-section of industries ...
(Date:12/6/2016)... ... December 06, 2016 , ... People ... can be seen on a type of MRI, according to a study appearing ... of the central nervous system characterized by tremors or trembling and stiffness in ...
(Date:12/6/2016)... ... December 06, 2016 , ... According to a November 1 ... consuming too many mints or not drinking enough water, which can cause bad breath ... Care notes that good oral hygiene not only helps reduce the possibility of bad ...
(Date:12/6/2016)... , ... December 06, 2016 , ... Mount Sinai Health ... the Department of Neurosurgery, where clinicians can confer and order 3D models for their ... low-cost fee-for-service basis with quick turnaround times. This resource will be the first ...
(Date:12/6/2016)... , ... December 06, 2016 , ... CarriersEdge, providers of ... a new suite of Driver Wellness courses. Offered in three modules, the courses can ... point so fleets can educate drivers about how to stay healthy on the road. ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... 2016  "Blood Tests replace Surgical Biopsies. Single ... The Diagnostic, Monitoring and Screening Test opportunities are ... occurring using in vitro blood testing to identify ... backing, has announced a single blood test to ... than the market. New technology that definitively identifies ...
(Date:12/6/2016)... -- The pen needles market is projected to reach ... in 2016, growing at a CAGR of 11.2% during ... the years, the pen needles market has witnessed various ... demand for safety injections in the healthcare industry. These ... needles with an aim to reduce pain, increase comfort, ...
(Date:12/6/2016)... -- BTL Aesthetics today announced the release of a ... device was effectively redesigned for more efficient, predictable ... The result: Significantly better outcomes in abdominal fat ... versus BTL Vanquish. "We are committed ... with the most highly-advanced devices on the market," ...
Breaking Medicine Technology: