Navigation Links
Non-human sugar in biotech drugs causes inflammation
Date:7/25/2010

Researchers at the University of California, San Diego School of Medicine have discovered that a kind of sugar molecule common to chimpanzees, gorillas and other mammals but not found in humans provokes a strong immune response in some people, likely worsening conditions in which chronic inflammation is a major issue.

This non-human sialic acid sugar is an ingredient in some biotechnology drugs, and may be limiting or undermining their therapeutic effectiveness in some patients, the scientists report in a letter published in the advance online July 25 edition of the journal Nature Biotechnology. However, they also propose a simple modification to the drug-making process that could solve the problem.

The presence of the non-human sialic acid sugar contaminant, called N-glycolyneuraminic acid or Neu5Gc, has long been known but ignored because it was believed healthy human immune systems did not react to it, said Ajit Varki, MD, professor of medicine and cellular and molecular medicine at UC San Diego School of Medicine. "Now we know that to be untrue." "We're all exposed to this non-human sugar," Varki added. "It's part of our diet, and especially abundant in red meat. We all develop antibodies to Neu5Gc, but this immune response varies greatly in people. Meanwhile, Neu5Gc from animal foods can get incorporated into the human body. For most people, this may not be a problem. But for some, the immune response to incorporated Neu5Gc may exacerbate a chronic inflammation process. This isn't the cause of any disease or condition, but we believe it might be akin to adding fuel to an existing fire."

Every animal cell is cloaked in sugar molecules, which serve as vital contact points for interaction with other cells and their surrounding environment. At the same time, the attached sugars are targets for infectious diseases like influenza, malaria and cholera.

"Sialic acids are required for survival, but they're also used t
'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Tight Blood Sugar Control in Older Diabetics May Not Reduce Heart Risk
2. Insulin Pump With Blood Sugar Sensor May Improve on Injections
3. Sensor and insulin pump results in better blood-sugar control in all age groups with diabetes
4. Mothers high blood sugar in pregnancy is linked to childrens reduced insulin sensitivity
5. Fructose sugar makes maturing human fat cells fatter, less insulin-sensitive
6. Junk Food Sugar May Help Some Fat Cells Proliferate
7. Key Blood Sugar Test Seems to Differ By Race
8. University of Pennsylvania: Contrary to popular models, sugar is not burned by self-control tasks
9. Glucose Tattoo Could Track Blood Sugar Levels for Diabetics
10. Fewer Sugary Drinks, Less High Blood Pressure
11. Sugar Before Shots Helps Infants Cope
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... 2014 Top10BestSEOHosting.com, a leading review ... and GreenGeeks are the most recommended hosting suppliers ... high quality hosting products. , “Don’t waste ... we recommend two great hosting companies to you,” ... that iPage and GreenGeeks are the most recommended ...
(Date:9/20/2014)... Recently, UWDress.com, a professional company of women’s dresses and ... announced evening cocktail dresses . As a matter ... are very popular among worldwide customers. Now, all its ... to 65 percent off). , All UWDress.com’s employees ... outfits for the global clients. The company is famous ...
(Date:9/20/2014)... Weight Destroyer , a weight ... Michael Wren that has already helped tens of thousands ... conditions like high blood pressure, high cholesterol, and accelerated ... an investigative review. , “Weight Destroyer is totally ... by showing people what is truly effective when it ...
(Date:9/20/2014)... Atlanta, GA (PRWEB) September 20, 2014 ... September 20, 2014. The first poster looked at the ... per cardiac cycle for calculating diastolic function. In conjunction ... with end-stage renal disease and normal LVEF by echo ... high-dose stress protocol, and standard SPECT. Emory Toolbox ...
(Date:9/20/2014)... 20, 2014 Villa del Palmar at ... not experience any damage in relation to Hurricane Odile ... available. , Hurricane Odile struck Cabo San Lucas the ... and powerful surf conditions. Located on the east side ... Loreto experienced some heavy rain, but no damage whatsoever ...
Breaking Medicine News(10 mins):Health News:Leading Review Website Top10BestSEOHosting.com Unveils The Best Hosting Suppliers In September 2Health News:Cheap Evening Cocktail Dresses Recently Introduced At UWDress.com 2Health News:Weight Destroyer: Review Exposes Michael Wren’s Guide to Effective Weight Loss and Improved Health 2Health News:Weight Destroyer: Review Exposes Michael Wren’s Guide to Effective Weight Loss and Improved Health 3Health News:Versatility of Emory Toolbox 4.0 Shown at ASNC in Scientific Posters 2Health News:Versatility of Emory Toolbox 4.0 Shown at ASNC in Scientific Posters 3Health News:Villa del Palmar at the Islands of Loreto Fully Functioning After Hurricane 2Health News:Villa del Palmar at the Islands of Loreto Fully Functioning After Hurricane 3
... counts soar when evergreens are brought indoors, researchers find , , ... live Christmas tree marks the beginning of the holiday season ... trigger weeks of suffering for some, a new study shows. ... a live Christmas tree rose to five times the normal ...
... LOS ANGELES, Nov. 16 Neutrogena(R), a worldwide ... cosmetics, announced today that actress Diane Lane has ... Ms. Lane is a captivating and inspiring ... beauty and daring spirit. In her new,role, she ...
... Allscripts, the leading,provider of clinical software, ... improve healthcare, on behalf of the National,ePrescribing ... for Medicare and Medicaid Services (CMS) proposal ... used by participants in the Medicare,prescription drug ...
... Directors and Reject ... Ramius, Opposition Slate, ... today mailed the following letter to all shareholders from,Lawrence Saper, ... the Company,s Annual Meeting of Shareholders scheduled for,Thursday, December 20, ...
... 16 Schering-Plough,Corporation (NYSE: SGP ) today ... U.S. Federal Trade Commission (FTC) regarding its,planned acquisition ... as,announced March 12, 2007. Organon BioSciences is ... Intervet, the animal health business. It also,includes Nobilon, ...
... Research &,Instrumentation, Inc. (CRi) announced today that their ... Mitalipov to successfully transfer,nuclear genetic material from somatic ... to generate cloned macaque embryos. In a soon ... Oregon National Primate,Research Center and the Oregon Stem ...
Cached Medicine News:Health News:Live Christmas Trees Can Trigger Mold Allergies 2Health News:Live Christmas Trees Can Trigger Mold Allergies 3Health News:Update: Oscar-Nominated Actress Signs on as Neutrogena(R) Brand Ambassador 2Health News:National ePrescribing Patient Safety Initiative Supports Medicare Proposal to Adopt Additional Standards for ePrescribing 2Health News:National ePrescribing Patient Safety Initiative Supports Medicare Proposal to Adopt Additional Standards for ePrescribing 3Health News:National ePrescribing Patient Safety Initiative Supports Medicare Proposal to Adopt Additional Standards for ePrescribing 4Health News:National ePrescribing Patient Safety Initiative Supports Medicare Proposal to Adopt Additional Standards for ePrescribing 5Health News:Datascope Mails Letter to Shareholders 2Health News:Datascope Mails Letter to Shareholders 3Health News:Datascope Mails Letter to Shareholders 4Health News:Datascope Mails Letter to Shareholders 5Health News:Datascope Mails Letter to Shareholders 6Health News:Datascope Mails Letter to Shareholders 7Health News:Datascope Mails Letter to Shareholders 8Health News:Schering-Plough Receives Clearance From U.S. Federal Trade Commission for Planned Acquisition of Organon Biosciences N.V. 2Health News:Oosight Imaging System Enables a Breakthrough: The Viable Transfer of Genetic Material for Stem Cell Nuclear Reprogramming in Primates 2
(Date:9/19/2014)... 19, 2014  Alere Inc. (NYSE: ALR ... following statement today in support of President Barack ... "As the global leader in rapid diagnostics for infectious ... strategy to address the serious threat of antibiotic resistance. ... Administration on initiatives to promote the development of rapid ...
(Date:9/19/2014)... , Sept. 19, 2014  The body of ... the publication of two papers this past week.  The ... Head and Neck Surgery , finds that withholding ... subjective measures of sleep disordered breathing, leading the paper,s ... in obstructive sleep apnea severity and improvement of quality ...
(Date:9/19/2014)... Sept. 19, 2014  CytRx Corporation (Nasdaq: ... in oncology, today announced that David J. Haen ... 2014 NewsMakers in the Biotech Industry Conference on Friday, September ... conference will take place at the Millennium Broadway Hotel ... A live and archived webcast of the presentation ...
Breaking Medicine Technology:Alere Applauds President's Executive Order Combating Antibiotic-Resistant Bacteria 2New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 2New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 3New Data shows Reductions in obstructive sleep apnea (OSA) severity and improvement of quality of life with Inspire therapy 4CytRx to Present at BioCentury's 2014 NewsMakers in the Biotech Industry Conference 2CytRx to Present at BioCentury's 2014 NewsMakers in the Biotech Industry Conference 3
... of Atlanta is the first hospital in Georgia to ... an advanced radiosurgery device specifically designed to treat brain ... , A gentler alternative to traditional brain surgery, ... radiation beams to one or more targets in a ...
... , FRANKLIN, Mass., Oct. 1 Echo Therapeutics, Inc. ... company developing the needle-free Symphony(TM) tCGM System as a ... the Prelude(TM) SkinPrep System for transdermal drug delivery, announced ... Executive Officer, will present at the 4th Annual JMP ...
Cached Medicine Technology:Saint Joseph's Hospital First in Georgia to Offer Noninvasive Treatment of Brain Disorders with Leksell Gamma Knife Perfexion 2Saint Joseph's Hospital First in Georgia to Offer Noninvasive Treatment of Brain Disorders with Leksell Gamma Knife Perfexion 3Echo Therapeutics to Present at 4th Annual JMP Securities Healthcare Conference 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: