Navigation Links
Non-human sugar in biotech drugs causes inflammation
Date:7/25/2010

Researchers at the University of California, San Diego School of Medicine have discovered that a kind of sugar molecule common to chimpanzees, gorillas and other mammals but not found in humans provokes a strong immune response in some people, likely worsening conditions in which chronic inflammation is a major issue.

This non-human sialic acid sugar is an ingredient in some biotechnology drugs, and may be limiting or undermining their therapeutic effectiveness in some patients, the scientists report in a letter published in the advance online July 25 edition of the journal Nature Biotechnology. However, they also propose a simple modification to the drug-making process that could solve the problem.

The presence of the non-human sialic acid sugar contaminant, called N-glycolyneuraminic acid or Neu5Gc, has long been known but ignored because it was believed healthy human immune systems did not react to it, said Ajit Varki, MD, professor of medicine and cellular and molecular medicine at UC San Diego School of Medicine. "Now we know that to be untrue." "We're all exposed to this non-human sugar," Varki added. "It's part of our diet, and especially abundant in red meat. We all develop antibodies to Neu5Gc, but this immune response varies greatly in people. Meanwhile, Neu5Gc from animal foods can get incorporated into the human body. For most people, this may not be a problem. But for some, the immune response to incorporated Neu5Gc may exacerbate a chronic inflammation process. This isn't the cause of any disease or condition, but we believe it might be akin to adding fuel to an existing fire."

Every animal cell is cloaked in sugar molecules, which serve as vital contact points for interaction with other cells and their surrounding environment. At the same time, the attached sugars are targets for infectious diseases like influenza, malaria and cholera.

"Sialic acids are required for survival, but they're also used t
'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Tight Blood Sugar Control in Older Diabetics May Not Reduce Heart Risk
2. Insulin Pump With Blood Sugar Sensor May Improve on Injections
3. Sensor and insulin pump results in better blood-sugar control in all age groups with diabetes
4. Mothers high blood sugar in pregnancy is linked to childrens reduced insulin sensitivity
5. Fructose sugar makes maturing human fat cells fatter, less insulin-sensitive
6. Junk Food Sugar May Help Some Fat Cells Proliferate
7. Key Blood Sugar Test Seems to Differ By Race
8. University of Pennsylvania: Contrary to popular models, sugar is not burned by self-control tasks
9. Glucose Tattoo Could Track Blood Sugar Levels for Diabetics
10. Fewer Sugary Drinks, Less High Blood Pressure
11. Sugar Before Shots Helps Infants Cope
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... are Key Issues Facing State, LOS ANGELES, April ... first of several statewide forums on,Thursday, in which experts ... healthcare infrastructure and potential solutions., The 2008 Quality ... in healthcare workers, the wide disparities in quality of ...
... excluded or under-represented, researchers say , , TUESDAY, April ... the American clinical trial process suggests that the ... or under-represented women, older people, minorities, disabled individuals ... a big problem," said Daniel S. Goldberg, chief ...
... April 1, 2008 Breckenridge announced,today that it has ... and manufacture a generic ANDA product. Under terms of ... U.S. Food and Drug,Administration (FDA) for the product which ... U.S. sales of approximately $279 million, and,is patent protected ...
... days without food primed them for chemical onslaught and ... (HealthDay News) -- Fasting for two days before chemotherapy ... of these powerful drugs by shielding healthy cells while ... "The side effects of chemotherapy are one of the ...
... Customer relationship management company MedicareCRM(R) launches first, Web-based solution as a ... ... data, PORTLAND, Ore., April 1, 2008 ... massive report,that Medicare Advantage plans depend on to track enrollments within their,service ...
... is killed or badly injured every six seconds, experts say ... people die each year on the world,s roadways -- more ... diabetes. , In response to this growing epidemic, the United ... on road safety, to be held next year in Russia. ...
Cached Medicine News:Health News:Report Claims Clinical Trials Miss Many Populations 2Health News:Report Claims Clinical Trials Miss Many Populations 3Health News:Report Claims Clinical Trials Miss Many Populations 4Health News:Fasting Before Chemo Protects Healthy Cells 2Health News:Fasting Before Chemo Protects Healthy Cells 3Health News:Fasting Before Chemo Protects Healthy Cells 4Health News:Medicare Advantage Plans Have New, Better Way to Access CMS Data 2Health News:U.N. Seeks to Curb World's Traffic Deaths 2Health News:U.N. Seeks to Curb World's Traffic Deaths 3Health News:U.N. Seeks to Curb World's Traffic Deaths 4
(Date:12/24/2014)... 23, 2014   Assurex Health, a personalized ... healthcare providers for behavioral health and chronic pain ... million in equity financing from new and existing ... President and Chief Executive Officer. The ... of Assurex Health,s GeneSight ®  products.  ...
(Date:12/24/2014)... BARBARA, Calif. , Dec. 23, 2014 In ... Junior Doctors, Association of Sierra Leone , ... Sierra Leone for the treatment of local health ... While a new dedicated Ebola care center was constructed ... virus, the facility is not available for local Sierra Leonean ...
(Date:12/22/2014)... 22, 2014 NxStage Medical, Inc. (NASDAQ: ... dialysis products, announced today that the U.S. Food ... One™ to perform hemodialysis overnight while the patient ... hemodialysis. NxStage,s® System One is the first and ... this indication. Home nocturnal hemodialysis ...
Breaking Medicine Technology:Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 2Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 3Assurex Health Secures $30 Million Financing Round to Continue Growth in Neuropsychiatric Pharmacogenomics 4First Ebola Treatment Unit for Local Health Workers Arrives in Sierra Leone 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 3
... New Study Results Show Antibodies Against Cancer-Causing Virus,Types ... Times Greater Than Natural,Infection Levels, CHICAGO, June 05, ... at 18 months after the first of a ... 55 vaccinated with the GlaxoSmithKline,(GSK) cervical cancer candidate ...
... Elixir,Pharmaceuticals, Inc., announced today new preclinical data,confirming ... regulating,metabolism, decreasing body weight and managing blood ... during ENDO 07, The,Endocrine Society's 89th Annual ... focused on the development of drugs to ...
Cached Medicine Technology:Cervarix, the GSK Cervical Cancer Candidate Vaccine, Provides,Sustained Immune Response in 100 Percent of Women up to 55 Years of,Age 2Cervarix, the GSK Cervical Cancer Candidate Vaccine, Provides,Sustained Immune Response in 100 Percent of Women up to 55 Years of,Age 3Cervarix, the GSK Cervical Cancer Candidate Vaccine, Provides,Sustained Immune Response in 100 Percent of Women up to 55 Years of,Age 4Cervarix, the GSK Cervical Cancer Candidate Vaccine, Provides,Sustained Immune Response in 100 Percent of Women up to 55 Years of,Age 5Elixir Pharmaceuticals Presents Additional Preclinical Data,Demonstrating the Potential of Ghrelin Antagonism to Regulate,Metabolism, Body Weight and Glycemic Control 2Elixir Pharmaceuticals Presents Additional Preclinical Data,Demonstrating the Potential of Ghrelin Antagonism to Regulate,Metabolism, Body Weight and Glycemic Control 3Elixir Pharmaceuticals Presents Additional Preclinical Data,Demonstrating the Potential of Ghrelin Antagonism to Regulate,Metabolism, Body Weight and Glycemic Control 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: