Navigation Links
Non-dopaminergic drug preladenant reduces motor fluctuations in patients with Parkinson's disease
Date:2/10/2011

similar for patients receiving preladenant and placebo.

In Parkinson's disease, the brain's dopamine-producing cells falter and die, leading to movement-related or motor symptoms such as tremors, stiffness, slowness, and balance problems.

Levodopa, a compound converted into dopamine in the brain, is still the gold standard therapy for Parkinson's, but as the disease advances this standard drug works for increasingly shorter time periods. As a result, patients begin to experience impaired movement before their next scheduled dose of medication. The re-emergence of symptoms accompanying this "off-time" can make it difficult for patients to perform even the most basic functions, such as walking and dressing. In addition, over time patients tend to develop a sensitivity to levodopa therapy during "on-time" resulting in involuntary twisting, turning movements known as dyskinesia.

Currently available drugs widely used to treat Parkinson's disease correct for the loss of the neurotransmitter dopamine either by boosting available dopamine in the brain or directly stimulating dopamine receptors. New ways to treat the disease that better address motor fluctuations without adverse side effects continue to be sought. Preladenant is a non-dopaminergic medication that targets adenosine A2A receptors in the motor control areas of the brain. It may offer advantages over dopamine medications, possibly including fewer side effects.

The clinical trial was conducted at 44 sites in 15 countries. Preladenant is an investigational medicine and is not approved for use.


'/>"/>

Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3300
University of South Florida (USF Health)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Extra testosterone reduces your empathy
2. Surgery for obstructive sleep apnea reduces daytime drowsiness
3. Anti-estrogen medication reduces risk of dying from lung cancer
4. Drug reduces the increase in fear caused by previous traumatic experiences in mice
5. Loss of gene promotes brain-tumor development, reduces survival, study finds
6. Study shows that CPAP therapy reduces fatigue, increases energy in patients with sleep apnea
7. Low-dose aspirin reduces death rates from range of cancers by between 20 and 30 percent
8. Annual breast cancer screening beginning at age 40 reduces mastectomy risk
9. Regular exercise reduces large number of health risks including dementia and some cancers
10. Canola-type rapeseed oil reduces the level of fibrinogen, a cause of thrombosis and inflammation
11. National study shows CT screening of former, current smokers reduces lung cancer deaths
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/3/2015)... EMBARGOED FOR RELEASE UNTIL 2 P.M. ET, WEDNESDAY, ... of Mother’s Home to Gas Wells , PITTSBURGH, June 3, ... of natural gas wells drilled with hydraulic fracturing were more ... living farther from such wells, according to a University ... southwestern Pennsylvania birth records. , The finding does not ...
(Date:6/3/2015)... The Canton Group, a leading web and software ... that Tim Dodge has joined the company as Chief ... Group as it implements an ambitious growth strategy ... is a tech industry veteran who has developed and ... Before joining The Canton Group, Tim was Vice President ...
(Date:6/3/2015)... On the heels of a report predicting ... ( click here to review news coverage about the ... has the talent to become a world-leading center of ... other biological data are collected and analyzed to help scientists ... the elements of a perfect storm for bioinformatics leadership,” said ...
(Date:6/3/2015)... June 03, 2015 Alberto Grignolo, PhD, ... DIA’s upcoming Annual Meeting. DIA’s Global Inspire Award program ... of excellence, and commitment to service on a global ... Connector Award that annually recognizes one DIA member for ... the mission of DIA to foster innovation to improve ...
(Date:6/3/2015)... Z-Medica®, LLC, a leading developer and ... been designated as National Safety Month by the National ... Department for its commitment to public safety. , ... First Aid Kits (IFAK) over 100 times in the ... or traffic accidents. Each kit is equipped with what’s ...
Breaking Medicine News(10 mins):Health News:Fracking Proximity Associated with Lower Birth Weight 2Health News:Fracking Proximity Associated with Lower Birth Weight 3Health News:Fracking Proximity Associated with Lower Birth Weight 4Health News:The Canton Group Appoints Tim Dodge as Chief Marketing Officer 2Health News:Baltimore Poised to Become a World-Leading Hub of Multi-Billion Dollar Bioinformatics Industry 2Health News:Baltimore Poised to Become a World-Leading Hub of Multi-Billion Dollar Bioinformatics Industry 3Health News:Longtime DIA Champion and PAREXEL Executive Honored with Global Inspire Award at DIA’s Annual Meeting 2Health News:Longtime DIA Champion and PAREXEL Executive Honored with Global Inspire Award at DIA’s Annual Meeting 3Health News:Z-Medica Commends Tucson Police Department for Trauma Kit Utilization 2
... hardest hit states by this,legislation, WASHINGTON, July ... significant funding cuts under,legislation being considered in Congress, ... Plans., As Congress considers ways to halt ... are looking at the Medicare Advantage program to,pay ...
... Washington State Medical,Association (WSMA) opposes Initiative-1000, the measure ... was,emphatically voted on at the WSMA,s annual meeting ... fundamentally incompatible,with the role of physicians as healers," ... their trust in physicians and that bond of ...
... Dimes and Kmart--Working Together for Stronger, Healthier,Babies, WHITE ... birth rises in the U.S., Kmart,s partnership with March ... associates and customers,have raised an unprecedented $71 million through ... year, Kmart,s 2008 March for Babies,campaign topped the charts ...
... reflects concern for environment, MELROSE PARK, Ill., July ... announced today that it has surpassed the,sale of 1 ... the environment., "We are seeing more and more ... president of Jewel-Osco. "This is,likely due to the heightened ...
... long periods of time continue to be at increased ... new study in the July 15 issue of ... is an antibiotic-resistant bacterium that can cause a variety ... nostrils, although it can be found in other body ...
... Va., July 2 Paramount,Health Care Company, ... Antonio, Texas, has partnered with Silverchair Learning ... for their,organization,s employee training., Silverchair,s Learning ... programs for senior care organizations. The program ...
Cached Medicine News:Health News:Proposed Congressional Legislation Would Cut $222 Million from the Medicare Advantage Program in Massachusetts 2Health News:As I-1000 Signatures are Counted, Washington State Medical Association Opposition to Physician-Assisted Suicide Reiterated 2Health News:4 Million Babies Born Each Year in United States; $8 Million That Shows You Care About All of Them! 2Health News:Jewel-Osco: 1 Million Reusable Shopping Bags Sold 2Health News:Being an MRSA carrier increases risk of infection and death 2Health News:Paramount Health Care Company Partners With Silverchair Learning Systems 2
(Date:6/3/2015)... , June 3, 2015 AVT, Inc. (OTC ... automated retailing systems, announced today that their customer, Pharmabox, ... The unique self-service kiosk carries over 140 top selling ... Target, CVS, Walgreen,s or Rite Aid-type store. ... Journal , Miami -based Pharmabox worked ...
(Date:6/3/2015)... Research and Markets  ( http://www.researchandmarkets.com/research/dg23tb/global ) has announced the ... report to their offering. The Global ... 5.9% over the period 2014-2019. One key ... in demand for vials and ampules. The Parenteral Containers ... all the segments at a CAGR of 8.83 percent ...
(Date:6/3/2015)... DALLAS , June 3, 2015  VA ... today with the successful patient implant of vBloc, a technology-based, ... vBloc is a pacemaker-like implant called the Maestro® ... signals or transmission of messages involving food intake ... Maestro System is wireless and customizable to meet ...
Breaking Medicine Technology:Pharmabox Introduces New Concept with a Boldly Designed Automated Retailing System 2Global Pharmaceutical Packaging Market 2015-2019 with Amcor, Bemis Healthcare Packaging, Gerresheimer, MeadWestvaco, Owens-Illinois & West Pharmaceutical Services Dominating 2VA North Texas First VA in the Country to Perform vBloc Implant, a Cutting-Edge Weight Loss Therapy 2VA North Texas First VA in the Country to Perform vBloc Implant, a Cutting-Edge Weight Loss Therapy 3
... July 1 Caraco Pharmaceutical Laboratories, Ltd. (NYSE ... capsules. These products, approved by the US Food and ... Application (ANDA), are therapeutically equivalent to Exelon® capsules from ... to moderate Alzheimer,s dementia and mild to moderate Parkinson,s ...
... BEIJING , July 1 /PRNewswire-Asia-FirstCall/ ... the development, assembly, marketing and,sale of medical devices and homecare medical products ... Financial Officer, and Sam Shuguang Gui, Vice,President of Strategic Development, will present ... San Francisco, CA. , , ...
Cached Medicine Technology:Caraco Pharmaceutical Laboratories, Ltd. Markets Generic Exelon® Capsules 2Dehaier Medical Systems to Present to Investors at Global Hunter Securities 2010 China Investor Conference in San Francisco 2Dehaier Medical Systems to Present to Investors at Global Hunter Securities 2010 China Investor Conference in San Francisco 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: