Navigation Links
Non-dopaminergic drug preladenant reduces motor fluctuations in patients with Parkinson's disease
Date:2/10/2011

Tampa, FL (Feb. 10, 2011) -- Preladenant, a non-dopaminergic medication, reduces off time in patients with Parkinson's disease receiving standard dopamine therapy, an international study led by the University of South Florida found.

Results of the double-blind, randomized clinical trial are reported online today in the journal Lancet Neurology. The findings suggest that preladenant may offer a new supplemental treatment for Parkinson's disease without some of the complications of levodopa and other standard dopamine treatments.

"The goal of treatment is to provide the best possible function and quality of life to patients over time," said lead author Dr. Robert A. Hauser, director of the Parkinson's Disease and Movement Disorders Center at USF. "After a few years, many patients find that their traditional Parkinson's disease medications wear off after a few hours leading to a re-emergence of symptoms. In this study, preladenant was shown to reduce off time, thereby affording patients more time through the day with better function."

Dr. Hauser and colleagues evaluated the safety and effectiveness of a range of doses of preladenant in 253 patients experiencing "wearing off" symptoms from their levodopa therapy. The patients were also receiving other available anti-parkinsonian drugs, such as dopamine agonists and/or entacapone.

The 12-week study found that the addition of 5 and 10 mg of preladenant twice daily significantly reduced "off time" -- the re-emergence of troublesome motor symptoms such as slowness, stiffness, tremors, and immobility when compared to patients receiving similar doses of placebo. Futhermore, preladenant significantly increased "on time" the period during which patients' Parkinson's symptoms were adequately controlled --.without significantly worsening dyskinesia (involuntary twisting, turning movements). The doses were well tolerated, and the incidence of treatment-related adverse effects was
'/>"/>

Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3300
University of South Florida (USF Health)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Extra testosterone reduces your empathy
2. Surgery for obstructive sleep apnea reduces daytime drowsiness
3. Anti-estrogen medication reduces risk of dying from lung cancer
4. Drug reduces the increase in fear caused by previous traumatic experiences in mice
5. Loss of gene promotes brain-tumor development, reduces survival, study finds
6. Study shows that CPAP therapy reduces fatigue, increases energy in patients with sleep apnea
7. Low-dose aspirin reduces death rates from range of cancers by between 20 and 30 percent
8. Annual breast cancer screening beginning at age 40 reduces mastectomy risk
9. Regular exercise reduces large number of health risks including dementia and some cancers
10. Canola-type rapeseed oil reduces the level of fibrinogen, a cause of thrombosis and inflammation
11. National study shows CT screening of former, current smokers reduces lung cancer deaths
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... (PRWEB) April 18, 2015 Heritage Woods ... begin its Supportive Living Week Celebration on April 20 ... having a healthy mind, body and soul. , The ... McLeansboro, Illinois, serves older adults of all incomes, including ... their independence. , Supportive Living Week is observed every ...
(Date:4/17/2015)... April 17, 2015 Alcohol and Violence ... (NCADD) notes that drinking and driving has been the ... the same time, the link between alcohol and crime ... abuse and violence and sexual assault, and their relationship ... the NCADD, 5.3 million adults in America were drinking ...
(Date:4/17/2015)... 2015 Consumers who prefer to have ... can now use the Insurance Pros USA website for ... rates that are featured by leading companies quoting plans ... are offered are mixed between three of the most ... There are now term, universal and whole policies that ...
(Date:4/17/2015)... Most dental patients are not aware that ... overseas by foreign dental laboratories, according to the U.S. ... more than 40 states by their respective state boards ... Laboratories has created the “What’s In Your ... the consequences that could be associated with using poorly-made ...
(Date:4/17/2015)... The American College of Traditional Chinese Medicine (ACTCM) is a ... 29. The event will be held from 11 a.m. to 4 ... in San Francisco, CA. , The agenda for the day is ... campus (room F), 11:10 a.m. – Introduction and welcome by ... with current students, faculty and staff, 1 p.m. – Observe clinic ...
Breaking Medicine News(10 mins):Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 2Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 3Health News:Narconon Arrowhead Raises Awareness on Alcohol Related Prevention 2Health News:Narconon Arrowhead Raises Awareness on Alcohol Related Prevention 3Health News:General Life Insurance Policy Rates Added to Quotation System at Insurance Website Online 2Health News:National Association Urges Transparency in Dental Industry 2Health News:American College of Traditional Chinese Medicine Hosts Open House 2
... ROSEMONT, ILWhile low-level shoulder separations can commonly be treated ... review published in the April 2009 issue of the ... ( JAAOS ) finds that many surgeons still ... injuries that fall in between. , , Shoulder ...
... April 2009 In children with vascular birthmarks around ... to visual loss due to amblyopia. Now a ... infants too young for conventional vision testing, reports a ... Journal of Ophthalmology ( http://www.elsevier.com/locate/ajo ) published by ...
... These new insights represent an important contribution to future ... prestigious science journal Nature and will be ... molecular mechanisms of hematopoiesis, which will take place in ... findings on the molecular mechanisms of blood formation (hematopoiesis) ...
... Awareness Month. , ... Bethesda, MD (Vocus) April 1, ... showed nearly 80 percent of surveyed families with a child with ... achieve independence as an adult, occupational therapy practitioners can help. They ...
... Sodexo Organization for disAbilities Resources champions company,s effortsGAITHERSBURG, ... 2009 Disability Matters Award in the category of ... to supporting people with disabilities and their families. ... Magazine and Springboard Consulting. The integrated food and ...
... As the economic crisis deepens, SilverCensus.com Inc. ( ... web site for caregivers, senior citizens, and healthcare ... Veterans to investigate and take advantage of a ... and Attendance." http://www.silvercensus.com/index.php/articles/veterans-application-for-compensation-andor-pension ...
Cached Medicine News:Health News:Healing a shoulder separation 2Health News:Test allows early detection of vision problems in infants with hemangiomas of eyelids 2Health News:Last step leading to blood cell formation elucidated 2Health News:Occupational Therapy Practitioners Identify Early Signs Of Autism Spectrum Disorder, Help Families Participate In Daily Routines 2Health News:Occupational Therapy Practitioners Identify Early Signs Of Autism Spectrum Disorder, Help Families Participate In Daily Routines 3Health News:Sodexo Receives 2009 Disability Matters Award 2Health News:Sodexo Receives 2009 Disability Matters Award 3Health News:Little-Known VA Care Entitlement for Veterans Highlighted by SilverCensus.com 2Health News:Little-Known VA Care Entitlement for Veterans Highlighted by SilverCensus.com 3
(Date:4/17/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/kh5kqg/the_corporate ) ... Corporate Reputation of Pharma - The Patient Perspective ... to their offering. The Corporate Reputation ... its fourth edition. This report contains the latest ... annual Corporate Reputation report, the author surveys a ...
(Date:4/17/2015)... , April 17, 2015 TWi Pharmaceuticals, ... subsidiary, TWi Pharmaceuticals USA , has ... the United States.  It has been in close contact ... and expects to have its own label specialty generic ... in the U.S. pharma market. According to ...
(Date:4/16/2015)... Mass. , April 16, 2015  Hologic, ... important cervical cancer screening study i published ... a peer-reviewed journal of the American Cancer Society. ... Diagnostics and the University of Pittsburgh Medical Center, supports current ... which recommend that women 30-65 years of age ...
Breaking Medicine Technology:The Corporate Reputation of Pharma - The Global Patient Perspective in 2014 2Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 2Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 3Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 4
... and ... additional safety studies, LEVERKUSEN, Germany and WEST HAVEN, Conn., ... the Drug,Safety and Risk Management Advisory Committee to the U.S. Food ... profile of,Trasylol(R) (aprotinin injection), a Bayer drug used in coronary artery,bypass ...
... STEWARTVILLE, Minn., Sept. 12 Rochester,Medical Corporation ... publication of,results from a significant clinical study ... proprietary Infection Control Technology. The newly ... Internal Medicine",presents results of a randomized, double-blind, ...
Cached Medicine Technology:FDA Advisory Committees Recommend Continued U.S. Marketing Authorization for Trasylol(R) 2FDA Advisory Committees Recommend Continued U.S. Marketing Authorization for Trasylol(R) 3Rochester Medical Anti-Infection Foley Catheter Demonstrates Effectiveness in Randomized Trial 2Rochester Medical Anti-Infection Foley Catheter Demonstrates Effectiveness in Randomized Trial 3
Adjustable speed vortex with inter-changeable heads , 110 V...
Inquire...
Adjustable speed vortex with inter-changeable heads, 110 V...
Use the Mo Bio Vortex adapter to process multiple samples at the same time. The adapter holds tubes horizontally to increase cell lysis and mixing efficiency. Ideal for bead beating procedures....
Medicine Products: