Navigation Links
Non-IV-administered medication just as effective in stopping seizures
Date:6/7/2010

CINCINNATIWhen seizures strike, the most immediate goal for caregivers is to get appropriate medication to the patient as quickly as possible to stop the seizing activity.

In a paper published in the June Academic Emergency Medicine, UC emergency medicine assistant professor Jason McMullan, MD, found that the best means of stopping status epilepticus (SE) may be with the least direct medication.

In the meta-analysis, McMullan compiled the results of six studies featuring 774 patients. His analysis compared the efficacy of two seizure medications, diazepam and non-intravenous midazolam, in stopping SE in children and young adults.

Both medications are in a class of drugs called benzodiapines, with diazepam the more commonly used anti-seizure drug in pre-hospital settings. While diazepam is typically administered by either suppository or IV, midazolam can be administered by a shot in the muscle or intranasally.

In the minutes after a seizure, the method of administration can make a big difference, says McMullan.

"Establishing IV access can be challenging, if not impossible, in convulsing patients," he says. While an intravenous medication may access the bloodstream faster, it can take a long time before the patient actually gets the medicine.

"Suppositories present another challenge," adds McMullan, because some caregivers may be unwilling to administer a suppository to a seizing child in a public place.

"It may be a little bit slower for midazolam administered via shot or nasal spray to work," he says, "but when you factor in the time to start the IV or administer a suppository, then it becomes a lot quicker."

During a seizure, time saved often translates into a better outcome for the patient.

"Most seizures stop on their own, but there times that they don'tand when they don't, that's a true emergency," says McMullan. "If a person is seizing for five or more minutes, the chances of the seizure stopping on its own are far less. During that time the person can suffer brain damage, muscle damage, a lack of oxygen, kidney damage, any number of things. The sooner that person is treated, the better they're going to do and the less medicine that they need."

In the analysis, McMullan found that midazolam, administered by any route, was superior to diazepam for stopping seizures, by any route. Not only was midazolam administered faster that diazepam, it had no greater rate of respiratory side effects.

While McMullan cautions that further studies including adult patients and comparing other anti-seizure medications are needed, he is optimistic about what this means for advancing the standard of care in seizures.

"In broad strokes, these results mean midazolam could be a good idea for seizure treatment. It's no worse than the gold standard of putting the drug directly into the bloodstream, it's no more dangerous and it's quicker. The real promise if that it may open the possibility for more EMS agencies to use this medication."


'/>"/>

Contact: Katy Cosse
kathryn.cosse@uc.edu
513-558-0207
University of Cincinnati Academic Health Center
Source:Eurekalert

Related medicine news :

1. PharmMD Secures Investments to Fund New Opportunities in Medication Therapy Management
2. Northeast Chiropractic, PC Revolutionizes Pain Management Without Medication, Now Offering New and Unique Blend of Treatments
3. Pharmacists Encourage Consumers to Practice Safe Medication Storage and Disposal
4. Anti-spasticity medications need further research
5. Study highlights lack of patient knowledge regarding hospital medications
6. Pathological Gambling May Be Successfully Treated With Medications for Substance Addiction
7. Medicine-On-Time Partners With QuickMAR to Streamline Medication Management and Improve Patient Care
8. Herpes medication does not reduce risk of HIV transmission, UW-led international study finds
9. A novel computational model -- how Parkinsons medications affect learning and attention
10. First Oral Medications For MS Show Promise
11. Racial differences in medication use
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... ... February 27, 2017 , ... Much attention has been paid to the ... dependent on opioid painkillers has fallen short. From 1999 until 2010, fatal overdoses from ... in fatal overdoses in male populations.(1) , The proportion of women using illicit drugs ...
(Date:2/27/2017)... Shenzhen, China (PRWEB) , ... February 26, 2017 , ... ... , This pioneer sound and video system brings songs, movies, TV shows and much ... 3D sound offers clear, high-definition sound. An immersive view of 1280 x 720 provides ...
(Date:2/27/2017)... ... February 27, 2017 , ... Silicon Valley Hair Institute, ... announce an upgrade to the company's Yelp listing. Bay Area residents struggling from ... diverse as Platelet Rich Plasma (PRP) therapy, hair transplantation techniques such as Follicular ...
(Date:2/26/2017)... ... February 26, 2017 , ... NuevaCare, a leading home care agency based in ... Palo Alto, is proud to announce an important upgrade to its geographic information pages, ... care close to home, and by having city-specific pages, NuevaCare is answering that information ...
(Date:2/26/2017)... ... February 26, 2017 , ... Functional imaging data ... to a study released today at the 1st Pan American Parkinson’s and Movement ... to be effective in improving cognitive function in PD patients. This study, led ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... DUBLIN , Feb. 24, 2017 Research and ... Analysis & Trends - Industry Forecast to 2025" report to their ... The Global Empty ... over the next decade to reach approximately $2.9 billion by 2025. ... all the given segments on global as well as regional levels presented ...
(Date:2/24/2017)... HILL, N.C. , Feb. 24, 2017 /PRNewswire/ ... are exploring ways to increase their self-service capabilities ... Health Care Providers (HCPs). New research ... many pharma organizations have developed self-service website portals ... electronically.  This is just one of many findings ...
(Date:2/24/2017)... le 24 février 2017 ITL Limited, ( ASX : ITD ... est ravie d,annoncer les excellents résultats semestriels clos le ... correspondante. Une présentation complète « Résultats et mise à jour ... ici . Faits marquants ... 2015 : 1,04 million $ ; en hausse de 104 %) ...
Breaking Medicine Technology: