Navigation Links
Non-Hormonal Therapies Aid Breast Cancer Patients

This applies to women with metastatic or recurrent inoperable disease, report says

TUESDAY, Dec. 9 (HealthDay News) -- Over the last 35 years, non-hormonal treatments have improved overall survival of patients with advanced breast cancer.

So say Greek researchers who conducted a review of 128 clinical trials that included more than 26,000 women with the disease.

The review showed that use of anthracycline regimens led to a 22 percent relative risk reduction in overall death, compared with older single-agent chemotherapy. Single drug taxane treatment led to a relative risk reduction of 33 percent, while a combination of a taxane with capecitabine or gemcitabine led to a 51 percent relative risk reduction over single-agent chemotherapy.

Most of the regimens appeared to be effective whether or not women had received a prior treatment.

"Our meta-analysis quantifies the progress achieved in the treatment of advanced breast cancer with nonhormonal systemic treatment in the last 35 years. Several regimens have shown effectiveness, and for some of them, the treatment effects are practically indistinguishable in magnitude," the review authors wrote. "Given that subsequent lines of treatment can confer similar relative benefits as the first-line setting, one can exploit the survival benefits conferred by several effective regimens used in sequential fashion."

The study was published Dec. 9 in the Journal of the National Cancer Institute.

This review is important because there has been no consensus regarding the best dosage, timing, sequence or combination of therapies for treatment of metastatic breast cancer, due to the fact that standard comparators haven't been available, Dr. Philippe Bedard and Dr. Martine Piccart-Gebhart, of the Jules Bordet Institute in Brussels, Belgium, wrote in an accompanying editorial.

The finding that many of the regimens have similar relative effectiveness in both untreated and previously treated patients means that other considerations, such as toxicity, will continue to help determine the choice of regimen for individual patients, the researchers said.

"Although this network meta-analysis is unlikely to alter routine clinical practice, it provides a solid evidence-based foundation to support the observation that the survival of women diagnosed with advanced breast cancer has improved because of more active systemic chemotherapy and targeted therapy," Bedard and Piccart-Gebhart wrote. "This should provide hope to patients, investigators, industrial sponsors, and regulatory agencies alike that well-designed clinical trials with novel systemic therapies can further alter the natural history of this devastating disease."

More information has more about recurrent and metastatic breast cancer.

-- Robert Preidt

SOURCE: Journal of the National Cancer Institute, news release, Dec. 9, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Bogus Stem Cell Therapies Sold on Internet
2. Market for Cellular Therapies Will Grow at a Robust Annual Rate of More Than 30 Percent in the United States Through 2017
3. Non-white med students reject therapies associated with their culture
4. Chemotherapy plus targeted therapies shows improved survival in advance-stage lung cancer patients
5. Stem cell therapies for heart disease -- 1 step closer
6. Texcel Introduces Innovative Programmable, Implantable Stimulation System for R&D of Specialty Stimulation Therapies
7. Study shows steroid therapies following transplant can be eliminated
8. Study Evaluates Laser Therapies for Hair Removal
9. New Journal to Explore Neurodegenerative, Neuroprotective and Euroregenerative Therapies!
10. New way to control protein activity could lead to cancer therapies
11. Session highlights of the 1st World Congress on Interventional Therapies for Type 2 Diabetes
Post Your Comments:
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term ... long-term care insurance companies have a waiver for care if the client has a ... when the family pays for care, is often waived, so the benefits from their ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has released ... understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a picture ... Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that is ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, ... Development, has been awarded a contract by the Center for Medicare and Medicaid ... to accelerate the enterprise use of Agile methodologies in a consistent and high ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: ... “America On The Brink” is the creation of published author, William Nowers. ... As a WWII veteran, he spent thirty years in the Navy. Following ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided an update ... Puerto Rico , where the company manufactures ... Following a comprehensive onsite assessment, the ... temporary loss of power and minimal water damage due ... have resumed, and the company expects to return to ...
(Date:10/7/2017)... --  Provista, a proven leader in the supply ... power, today announced a new resource area on ... is the online home for case studies, articles on ... releases, slideshows and events. ... at their fingertips, viewers can also watch short videos ...
(Date:10/4/2017)... 2017  According to the Centers for Disease Control and Prevention (CDC), ... PhysicianOne Urgent Care is helping communities across Massachusetts , ... by offering no-cost* flu shots through the end of the month. ... insurance regulations. ... get a flu shot is by the end of October, according to ...
Breaking Medicine Technology: