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Nobel laureates Brown, Goldstein to give inaugural Stadtman award lecture
Date:4/7/2011

BETHESDA, Md., April 7, 2011 The American Society for Biochemistry and Molecular Biology has named Nobel laureates Michael S. Brown and Joseph L. Goldstein, pioneers in the study of cholesterol metabolism, the joint winners of its first Earl and Thressa Stadtman Distinguished Scientist Award.

Brown and Goldstein will present their award lecture, "The SREBP Pathway: Stadtman's Paradigm Applied to Cholesterol," at 2:40 p.m. April 11 at the Experimental Biology 2011 Conference at the Walter E. Washington Convention Center.

Ira Pastan of the National Cancer Institute, who nominated the pair for the award, says their "sustained record of joint discoveries places them at the forefront of regulatory biochemistry, the field that was pioneered by Earl Stadtman."

Brown and Goldstein, both of the University of Texas Southwestern Medical Center at Dallas, shared the 1985 Nobel Prize in medicine or physiology for their discovery of the low-density lipoprotein, or LDL, receptor and the process of receptor-mediated endocytosis. In recent years, they discovered sterol regulatory element-binding proteins and the process of regulated intramembrane proteolysis.

"Joe and Mike are towering intellects and leaders in the field of biomedical sciences," says Phillip Sharp, a professor at the Koch Institute for Integrative Cancer Research at the Massachusetts Institute for Technology. "They are among the most recognized and celebrated scientists of their generation and remain active, producing excellent science on contemporary topics."

The researchers met at Massachusetts General Hospital in Boston in the 1960s and have collaborated ever since. From 1968 to 1971, Brown worked at the National Institutes of Health, initially as a clinical associate in gastroenterology and hereditary disease and later in the biochemistry laboratory headed by Earl Stadtman himself. Meanwhile, Goldstein spent 1968 through 1970 at the NIH as well, working in th
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Contact: Angela Hopp
ahopp@asbmb.org
301-634-7389
American Society for Biochemistry and Molecular Biology
Source:Eurekalert  

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Nobel laureates Brown, Goldstein to give inaugural Stadtman award lecture
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