Navigation Links
Nobel laureate James Watson publishes novel hypothesis on curing late-stage cancers
Date:1/8/2013

eat Britain's Royal Society.

He proposes that the cell-killing ability of currently used anti-cancer therapies toxic chemotherapeutic agents such as Taxol as well as radiation treatment is mainly due to the action of ROS to induce apoptosis, or programmed cell death. This would explain "why cancers that become resistant to chemotherapeutic control become equally resistant to radiotherapy." The common feature would be their common dependence upon a ROS-mediated cell-killing mechanism.

Watson, who is Chancellor Emeritus of Cold Spring Harbor Laboratory, then takes up the case of cancer cells largely driven by mutant proteins such as RAS and MYC. These, he notes, are often hardest to get to respond to treatment. He suggests this could be due to their high levels of ROS-destroying antioxidants. He cites recent research showing up-regulation of a gene transcription factor called Nrf2 when cells proliferate as well as when oncogenes such as RAS, MYC and RAF are active. Nrf2 controls the synthesis of antioxidants, and "this makes sense because we want antioxidants present when DNA functions to make more of itself," Watson writes.

In calling for "a much faster timetable for developing anti-metastatic drugs," the Nobel laureate wants those reading his new paper to consider a proposition he considers grossly underexplored: "Unless we can find ways of reducing antioxidant levels, late-stage cancer 10 years from now will be as incurable as it is today."


'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Sanford-Burnhams Erkki Ruoslahti named to Thomson Reuters Nobel Prize watch list
2. Nobel laureate to keynote international pharmaceutical conference at URI
3. NAI Fellows Robert Langer, Leroy Hood and Member James Wynne receive US National Medals
4. Before Skyfall: 46 years of violence in James Bond movies
5. James George, MD: 2012 ASH Wallace H. Coulter Award for Lifetime Achievement in Hematology
6. Medical Tourism: Uncharted Territory for Patients James Goldberg, Author of the American Medical Money Machine, Is Offering a New Consulting Service to Medical Patients Considering “Medical Tourism” Treatment
7. Same-Sex Couples Might File Tax Refund Claims According to Watson CPA Group
8. Few Hours Left for Charitable Tax Deductions According to Watson CPA Group
9. Astro Clairvoyant Norah Guide for Premium Astrology Publishes New Blog Series on 2013 Predictions
10. Atlanta Surgeon for LASIK Eye Surgery Publishes Study on Website About Car Technology to Monitor Drowsiness
11. Zane Benefits Publishes "The Crisis in Employee Health Benefits 1999-2012"
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... 29, 2014, 2 PM US Eastern Time)The current ... inject antibodies, commonly produced in animals, to neutralize ... from safety to difficulties in developing, producing and ... New research led by Charles Shoemaker, Ph.D., professor ... Health at the Cummings School of Veterinary Medicine ...
(Date:8/29/2014)... The microbiology testing sector is one of the ... is also the hugest challenge facing suppliers during these ... of AIDS – still the world’s key health threat ... opportunistic infections (OIs); bioterrorism threat; advancements in technologies for ... Although for certain infections the etiology remains a mystery, ...
(Date:8/29/2014)... FRIDAY, Aug. 29, 2014 (HealthDay News) -- Prostate cancer ... good treatment decisions. This can lead to worse quality ... The study included 70 men, with a median age ... cancer. Poor understanding of the disease was associated ... less confidence that the treatment would be effective, the ...
(Date:8/29/2014)... 2014 Edvance360, a leading provider of ... online teaching, as well as 2011 winner and six-time-finalist ... Management System, announced that Brooke Education Services, Northwest Academy, ... Interactive Advertising Bureau of Canada (IAB Canada), StarSVCS, and ... are delighted to welcome each new client to the ...
(Date:8/29/2014)... is a U.S. Food and Drug Administration (FDA)-approved ... raloxifene is as effective at reducing fracture risk ... by suppressing bone loss. With the use of ... respectively), researchers carried out experiments at the U.S. ... at Argonne National Laboratory that revealed an additional ...
Breaking Medicine News(10 mins):Health News:Mice study shows efficacy of new gene therapy approach for toxin exposures 2Health News:Infectious Disease Testing Universe Examined in New VPG Research Report Available at MarketPublishers.com 2Health News:Infectious Disease Testing Universe Examined in New VPG Research Report Available at MarketPublishers.com 3Health News:Faced With Prostate Cancer, It Helps to Know the Enemy 2Health News:Edvance360 Continues to Experience Growth in Corporate, K-12, Health, and Non-Profit Sectors 2Health News:Revealing a novel mode of action for an osteoporosis drug 2
... ... Roberto Giraldo shows that AIDS is a result of multiple, repeated and chronic exposure to ... and most of all, emotional. , ... Oakland, CA (PRWEB) November 8, 2009 -- From Nov. 6 – 8, 2009, ...
... Nov. 7 Today, the House of Representatives passed ... amendment to the "Affordable Health Care for America Act" ... preventing federal funding for abortion and for benefits packages ... who receive affordability credits and those who do not, ...
... H.R. 3961 to Secure the Stability of Medicare , ... M.D., President, American Medical Association. , (Logo: http://www.newscom.com/cgi-bin/prnh/20081209/AMALOGO ... the House health reform bill, which will help improve the ... passage of H.R. 3961 to secure the stability of the ...
... Calif., Nov. 8 March of Dimes hosted the ... individuals who are celebrating the birth of their children ... commitment to improve the health of babies. As ... Month campaign, celebrities and special guests were urged to ...
... , Jacquelyn T. Coleman (CT), David A. Cook ... David L. Tarver (LA) Honored , CHICAGO, Nov. ... five medical society executive leaders with achievement awards to ... the medical profession. The awards were presented at the ...
... , WASHINGTON, Nov. 7 The U.S. bishops November ... vote for the Stupak-Ellsworth Amendment to the health care ... current federal law on abortion funding and conscience protections ... 3962)," they said. , The letter was signed by ...
Cached Medicine News:Health News:Revolutionary New Views on AIDS Highlight the Rethinking AIDS 2009 Congress; Emotional Issues can be a Significant Contributing Factor 2Health News:Revolutionary New Views on AIDS Highlight the Rethinking AIDS 2009 Congress; Emotional Issues can be a Significant Contributing Factor 3Health News:Family Research Council Praises Passage of Pro-life Amendment to Health Care Bill 2Health News:AMA Hails House Passage of Health Reform Bill (H.R. 3962) 2Health News:Hollywood Stars Joined in a Celebration of Babies 2Health News:Hollywood Stars Joined in a Celebration of Babies 3Health News:AMA Honors Medical Society Executives 2Health News:Bishops Urge Passage of Stupak-Ellsworth Anti-Abortion Amendment for Health Reform Bill 2
(Date:8/29/2014)... Research and Markets  has announced the ... Devices Market 2014-2018" report to their offering. ... cells that connect, support, or surround bones. There are ... ligaments, cartilage, fascia, and other fibrous tissues. Repetitive use, ... age result in wear and tear in these tissues. ...
(Date:8/28/2014)... 28, 2014 Reportlinker.com announces ... is available in its catalogue: ... Services Industry (U.S.): Analytics, Extensive Financial ... 2021, NAIC 541380 ... Testing Laboratories, Safety and Compliance Services ...
(Date:8/28/2014)... -- Pharmatech initiated enrollment for its AccessPPM program ... for matching cancer patients to cancer clinical trials. ... cancers, disease staging, and genetic mutations - which ... the first place. The challenge that the industry ... well known to the patient or even their ...
Breaking Medicine Technology:Global Orthopedic Soft Tissue Repair Devices Market 2014-2018: Key Vendors are ArthroCare, Biomet, DePuy Synthes and Smith & Nephew 2Global Orthopedic Soft Tissue Repair Devices Market 2014-2018: Key Vendors are ArthroCare, Biomet, DePuy Synthes and Smith & Nephew 3Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 2Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 3Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 4Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 5Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 6Enrollment in Pharmatech's Revolutionary AccessPPM Program Launches 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: