Navigation Links
No substitute for hard work: Creatine supplementation does not improve exercise outcomes in COPD
Date:8/1/2008

Creatine, a popular nutritional supplement renowned for enhancing athletic performance and muscle strength, does not improve exercise outcomes in patients with chronic obstructive pulmonary disease (COPD), according to a new study. The randomized, placebo-controlled, double-blind study provided the most powerful evidence to date that the effect of creatine (Cr) supplementation was negligible at best among these patients.

"We have evidence to suggest Cr uptake into muscles [in COPD patients] but are unable to explain why an increase in muscle Cr did not enhance training," wrote the study's lead author, Sarah Deacon, M.D., specialist registrar at the Institute for Lung Health at Glenfield Hospital in Leicester, England.

The results were published in the first issue for August of the American Journal of Respiratory and Critical Care Medicine by the American Thoracic Society (ATS).

Cr supplementation has been shown to improve short-burst, high-intensity exercise function in athletes, as well as enhancing isometric muscle strength, lower body endurance and lean body mass in the elderly. To determine whether Cr supplementation could similarly enhance the physical condition of COPD patients, Dr. Deacon and co-researchers recruited 100 patients with COPD to either receive Cr or a placebo over the course of a seven week pulmonary rehabilitation program.

Those who were randomized to the placebo group were give lactose supplements that appeared identical to the Cr-containing supplements. Following a five-day loading period (22g/d Cr or 24 g/d lactose) each subject followed maintenance dosing of 3.76 or 4 g of Cr or lactose respectively.

Of the original 100 subjects, 80 successfully completed the study. In both control and Cr groups, there were statistically significant improvements in functional and muscular performance during the loading phase, but no differences were seen between the groups. The Cr group also showed a greater, but non-significant percentage of improvement in the incremental shuttle walking test with loading and after pulmonary rehabilitation, but additional analysis still showed no overall effect between it and the placebo group.

"The most likely explanation is that any benefits of creatine have been submerged by the large training effect of physical training alone," wrote Dr. Deacon.

This study, therefore, further validates that there is no substitute for the old-fashioned hard work that is an essential element of pulmonary rehabilitation. "Those of us interested in pulmonary rehabilitation are happy to see confirmation of the beneficial effects of exercise training. This information indicates that creatine supplementation not be viewed as a good substitute for exercise traininggood news for adepts of pulmonary rehabilitation," wrote Francoise Maltais, M.D., Didier Saey, Ph.D., and Richard Debigare, Ph.D., all of the Centre de Recherche de l'Hospital Laval Quebec in Canada.

"Without minimizing the importance of the quest to optimize the results of pulmonary rehabilitation, we had to appreciate that only a small portion of patients with COPD actually engage in pulmonary rehabilitation.so improved [access] is important for PR to achieve its full potential from a public health perspective."

Dr. John Heffner, past president of the ATS, commented that "these and other studies are finally gaining recognition that pulmonary rehabilitation is an essential element of comprehensive care for patients with COPD. The weight of the evidence has succeeded in gaining Medicare payment for rehabilitation services, which has been one of our major hurdles to access."


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Blood Substitute Found Safe in Large Phase III Trial
2. Smokeless Tobacco: Not a Harmless Substitute
3. NuVasive Acquires First Stem Cell Bone Graft Substitute
4. Northfield Laboratories Inc. Comments on Article and Editorial on Hemoglobin-Based Blood Substitutes to be Published in May 21 JAMA
5. Experimental Blood Substitutes Unsafe, Study Finds
6. Sugar Substitutes May Contribute to Weight Gain
7. Transcutaneous cervical esophageal ultrasound can not substitute for 24-h pH monitoring or manometry
8. Compromise SCHIP Deal Substitutes Ideology for Common Sense
9. ISTO Technologies Receives 510(k) Clearance for a Novel Bone Graft Substitute and Bone Graft Extender
10. New Drug No Substitute for Standard Blood-Clot Therapy
11. Statement From Mens Health Network: U.S. Presidential Candidates Overlook Real Problem in U.K. & U.S. Health Policies Towards Men
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/17/2017)... ... February 17, 2017 , ... Smiles by Seese is a comprehensive ... Dr. Brian Seese leads the practice as a skilled and highly credentialed dentist who ... by Seese serves patients of all ages with excellence in general, restorative, and ...
(Date:2/17/2017)... ... February 17, 2017 , ... ... FDAnews Webinar**, Feb. 22, 2017 — 1:30 p.m. – 2:30 p.m. ET, ... should be asking before selecting an FDA approval pathway? , How should ...
(Date:2/17/2017)... ... February 17, 2017 , ... ... 2017 season , Trinity Health and the U.S. Soccer Foundation announced today that ... in underserved communities. Soccer for Success, the Foundation’s soccer mentoring program, teaches kids ...
(Date:2/17/2017)... ... 17, 2017 , ... Like most hospitals across the nation, Onslow Memorial Hospital ... the Hospital Readmission Reduction Program (HRRP), the return of a patient to the hospital ... the nation. While many providers are struggling to leverage limited resources and technology, Onslow ...
(Date:2/16/2017)... (PRWEB) , ... February 17, 2017 , ... ... their experience can last long after their final treatments. Physician researchers at ... neuro-emotional technique (NET), a mind-body therapy, for efficacy in reducing symptoms of traumatic ...
Breaking Medicine News(10 mins):
(Date:2/16/2017)... 2017  Express Scripts (NASDAQ: ESRX ) was recognized ... Companies within the Health Care: Pharmacy and Other Services category. ... World,s Most Admired Companies," said Tim Wentworth , CEO and ... passion of our 26,000 employees to make medicine more affordable and ... ...
(Date:2/16/2017)...  Prescription pain medications provided by "physicians in the ... long-term opioid use to take hold," according to a ... of The New England Journal of Medicine ... in acute pain than in almost any other medical ... of the American College of Emergency Physicians. "The challenge ...
(Date:2/16/2017)... , Feb. 16, 2017   Spectralink ... solutions for the healthcare, retail, manufacturing and hospitality ... on the performance and symbology support features of ... a dual-mode camera/barcode scanner. The study, conducted by ... the PIVOT:SC to two phones with dedicated hardware ...
Breaking Medicine Technology: