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No increase in risk of death for patients with well-controlled HIV, reports AIDS journal
Date:3/11/2013

Philadelphia, Pa. (March 11, 2013) For HIV-infected patients whose disease is well-controlled by modern treatment, the risk of death is not significantly higher than in the general population, according to a study published in AIDS, official journal of the International AIDS Society. AIDS is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

The study suggests that patients with undetectable viral loads and near-normal levels of immune cells on state-of-the art antiretroviral therapy (ART) can expect to have about the same risk of death as people without HIV. The article is available on the AIDS journal homepage and in the March 13 print edition.

What's the Risk of Death with Well-Controlled HIV?

Dr Alison Rodger of University College London and colleagues assessed mortality rates in a group of patients with "optimally treated" HIV, drawn from two major trials of treatment for HIV infection: the ESPRIT and SMART trials. The analysis included nearly 3,300 patients who were not injecting drug users and who received continuous ART. On treatment, all had achieved undetectable HIV levels and had relatively high levels of CD4+ cells, a key population of immune cellsat least 350 cells/mm3. (A CD4+ cell count of 500 to 1,000 cells/mm3 is considered normal.)

The patients' average age was 43 years; 80 percent were men. Rates and causes of death in these patients with well-controlled HIV were compared with those in the general population.

During a median follow-up of about three years, 62 of the patients died. The most common causes of death were cardiovascular disease or sudden death, responsible for
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Contact: Connie Hughes
connie.hughes@wolterskluwer.com
646-674-6348
Wolters Kluwer Health
Source:Eurekalert

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