Navigation Links
No increase in commonest preventable cause of intellectual disability over 20 years
Date:7/18/2011

This release is available in French.

A new study that was prompted by recent reports of an increase in cases of congenital hypothyroidism in the United States, and aimed at assessing the incidence of this condition among Quebec newborns, suggests that the increase is entirely artifactual. CH is characterized by inadequate thyroid hormone production and is the most common cause of preventable intellectual disability. The results were published in the Journal of Clinical Endocrinology and Metabolism by Dr. Johnny Deladoy, a pediatric endocrinologist and researcher in metabolic and genetic diseases at CHU Sainte-Justine Research Center and an assistant professor of pediatrics and biochemistry at University of Montreal.

The increase in the number of cases identified may be an artifact due to changes in screening methods and results in the treatment of some children who may, in fact, not benefit from treatment. "Overly sensitive screening methods that identify mild cases of CH represent an obvious shift in neonatal screening from its original purpose, which was to identify severe cases in which the benefits from treatment would be clearly documented", Deladoy said. "This might explain why, in the United States, more than a third of children labelled as having CH on the basis of neonatal screening no longer receive treatment after four years of age."

The lack of consensus about the thresholds on which to base detection has always presented a challenge for CH screening. Quebec pioneered universal screening for CH in newborns, being the first jurisdiction on the globe to initiate such a program in 1973. Quebec strategies and methodologies have proven to deliver reliable results and may serve as a model in the standardization of CH screening and diagnosis worldwide.

Thanks to a contribution rate of more than 90 % of hospitals and physicians to a provincial database over a period of 20 years, the results from the detection and diagnosis of 620 cases of CH could be analyzed.

Details about the study:

Historical data were analyzed for the study jointly with the Qubec newborn blood screening laboratory located at the Centre hospitalier universitaire de Qubec (CHUQ). More precisely, of the 1,660,857 newborns tested over the 20-year period, 620 cases of CH were detected, diagnosed and treated. During the second half of the period, a slightly more sensitive detection threshold was applied in addition to those expected, 49 further cases of CH were detected, representing an 18 % increase. Most of these additional cases had mild functional disorders whose impact on mental development is uncertain. Most importantly, the number of detected cases would have remained stable throughout the period studied if the screening threshold had been unchanged.

The study was published ahead of print on June 1, 2011 in the Journal of Clinical Endocrinology and Metabolism by Dr. Johnny Deladoey of the CHU Sainte-Justine Research Center and University of Montreal, jointly with Dr. Guy Van Vliet, also of the CHU Ste-Justine, and Dr. Jean Ruel and Dr. Yves Gigure, of the Qubec newborn blood screening laboratory at the CHUQ.


'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Related medicine news :

1. Massachusetts health-care reform increased access to care, particularly among disadvantaged
2. Long-term NSAID use by hypertensive patients with CAD increases risk of adverse events
3. Loss of motion after knee surgery may increase osteoarthritis risk, research suggests
4. Obesity May Increase Risk of Surgical Complications
5. Previous cancer history increases chances of clotting disorders after knee surgery, study suggests
6. Medicaid increases use of health care, decreases financial strain, improves health
7. Increased investment in thoracic surgical expertise increased UK lung cancer resection rate
8. Varenicline for smoking cessation linked to increased risk of serious harmful cardiac events
9. Chantix associated with 72 percent increased risk of serious CV events
10. IASLC: Adjunctive use of 3-D imaging system increases utility of CT lung cancer screening
11. Study uncovers novel genetic variation linked to increased risk of sudden cardiac arrest
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Conference and Scientific Sessions in Dallas that it will receive two significant new ... the grants came as PHA marked its 25th anniversary by recognizing patients, medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, ... and the Road To Recovery® program to drive cancer patients to and from their ... to ensure the highest quality of life and ongoing independence. Getting to and ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... today at the Clinical Decision Making in Emergency Medicine conference in Ponte Vedra ... authored journal articles published in Emergency Medicine Practice and Pediatric Emergency ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... feeding the Frederick area economy by obtaining investment capital for emerging technology companies. ... 2½ years that have already resulted in more than a million dollars of ...
(Date:6/24/2016)... Gaithersburg, MD (PRWEB) , ... June 24, 2016 ... ... and protocols for human induced pluripotent stem (iPS) cells and other difficult to ... PluriQ™ G9™ Cloning Medium. The PluriQ™ G9™ Gene Editing System is ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Belgium , June 24, 2016 /PRNewswire/ ... announced the appointment of Dr. Edward Futcher ... a Non-Executive Director, effective June 23, 2016.Dr. Futcher ... and Nominations and Governance Committees.  As a non-executive ... provide independent expertise and strategic counsel to VolitionRx ...
(Date:6/23/2016)... Research and Markets has announced the ... to 2022" report to their offering. ... patients with kidney failure, it replaces the function of kidneys ... blood and thus the treatment helps to keep the patient ... Increasing number of ESRD patients & substantial ...
(Date:6/23/2016)... , June 23, 2016  In a startling report released today, ... their residents by lacking a comprehensive, proven plan to eliminate prescription ... definitive ranking of how states are tackling the worst drug crisis ... four states – Kentucky , New ... Vermont . Of the 28 failing states, three – ...
Breaking Medicine Technology: