Navigation Links
No increase in commonest preventable cause of intellectual disability over 20 years
Date:7/18/2011

This release is available in French.

A new study that was prompted by recent reports of an increase in cases of congenital hypothyroidism in the United States, and aimed at assessing the incidence of this condition among Quebec newborns, suggests that the increase is entirely artifactual. CH is characterized by inadequate thyroid hormone production and is the most common cause of preventable intellectual disability. The results were published in the Journal of Clinical Endocrinology and Metabolism by Dr. Johnny Deladoy, a pediatric endocrinologist and researcher in metabolic and genetic diseases at CHU Sainte-Justine Research Center and an assistant professor of pediatrics and biochemistry at University of Montreal.

The increase in the number of cases identified may be an artifact due to changes in screening methods and results in the treatment of some children who may, in fact, not benefit from treatment. "Overly sensitive screening methods that identify mild cases of CH represent an obvious shift in neonatal screening from its original purpose, which was to identify severe cases in which the benefits from treatment would be clearly documented", Deladoy said. "This might explain why, in the United States, more than a third of children labelled as having CH on the basis of neonatal screening no longer receive treatment after four years of age."

The lack of consensus about the thresholds on which to base detection has always presented a challenge for CH screening. Quebec pioneered universal screening for CH in newborns, being the first jurisdiction on the globe to initiate such a program in 1973. Quebec strategies and methodologies have proven to deliver reliable results and may serve as a model in the standardization of CH screening and diagnosis worldwide.

Thanks to a contribution rate of more than 90 % of hospitals and physicians to a provincial database over a period of 20 years, the results from the detection and diagnosis of 620 cases of CH could be analyzed.

Details about the study:

Historical data were analyzed for the study jointly with the Qubec newborn blood screening laboratory located at the Centre hospitalier universitaire de Qubec (CHUQ). More precisely, of the 1,660,857 newborns tested over the 20-year period, 620 cases of CH were detected, diagnosed and treated. During the second half of the period, a slightly more sensitive detection threshold was applied in addition to those expected, 49 further cases of CH were detected, representing an 18 % increase. Most of these additional cases had mild functional disorders whose impact on mental development is uncertain. Most importantly, the number of detected cases would have remained stable throughout the period studied if the screening threshold had been unchanged.

The study was published ahead of print on June 1, 2011 in the Journal of Clinical Endocrinology and Metabolism by Dr. Johnny Deladoey of the CHU Sainte-Justine Research Center and University of Montreal, jointly with Dr. Guy Van Vliet, also of the CHU Ste-Justine, and Dr. Jean Ruel and Dr. Yves Gigure, of the Qubec newborn blood screening laboratory at the CHUQ.


'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Related medicine news :

1. Massachusetts health-care reform increased access to care, particularly among disadvantaged
2. Long-term NSAID use by hypertensive patients with CAD increases risk of adverse events
3. Loss of motion after knee surgery may increase osteoarthritis risk, research suggests
4. Obesity May Increase Risk of Surgical Complications
5. Previous cancer history increases chances of clotting disorders after knee surgery, study suggests
6. Medicaid increases use of health care, decreases financial strain, improves health
7. Increased investment in thoracic surgical expertise increased UK lung cancer resection rate
8. Varenicline for smoking cessation linked to increased risk of serious harmful cardiac events
9. Chantix associated with 72 percent increased risk of serious CV events
10. IASLC: Adjunctive use of 3-D imaging system increases utility of CT lung cancer screening
11. Study uncovers novel genetic variation linked to increased risk of sudden cardiac arrest
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)... (PRWEB) , ... December 06, 2016 , ... ... advisory organization, is proud to announce it has added CXC Solutions (CXC) as ... management solutions. These solutions are tailored to help benefits advisors reduce operating ...
(Date:12/6/2016)... ... December 06, 2016 , ... ... portal for all the knowledge resources, including white papers, guides, handbooks, case studies, ... , To access more than 9,000 documents, webinars and videos available online, ...
(Date:12/6/2016)... ... December 06, 2016 , ... “Tatiana Sibirskaya: A Life ... story of sacrifice and enlightenment. , “Tatiana Sibirskaya: A Life Devoted ... looking for creative outlets, Carolyn gravitated toward writing through the inspiration of her ...
(Date:12/6/2016)... ... December 06, 2016 , ... U.S. Security Associates (USA) ... 125 for their industry leading training methods that engage their associates and link ... the global elite in employer-sponsored training and development programs. , “The 2017 Training ...
(Date:12/5/2016)... ... December 06, 2016 , ... For many years, Andrew G. Zubinas ... thin. The beauty of the Lithuanian language and its poetry inspired him ... book, Zubinas lyrically explores all aspects of a living, breathing forest where nothing ever ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... 2016  CVS Health, the nation,s largest pharmacy innovation ... score of 100 percent on the Corporate Equality Index ... an annual national benchmarking survey and report on corporate ... the Human Rights Campaign Foundation. "Our ... colleagues, customers and suppliers bring to CVS Health," said ...
(Date:12/5/2016)... 2016  New research by the CVS Health ... the U.S. Department of Health and Human Services, ... Response (ASPR), published online today in JAMA ... encourage patients with chronic conditions to refill medications ... also affirms that public-private partnerships can facilitate timely ...
(Date:12/5/2016)... 5, 2016 For the third consecutive year, ... Human Rights Campaign Foundation,s (HRC) annual ... national benchmarking tool used to rate companies on policies ... employee equality. For the last 15 years, ... gauge their equality efforts, culture and business practices. The ...
Breaking Medicine Technology: