Navigation Links
No firm conclusions about HDL cholesterol can be drawn from JUPITER sub-analysis
Date:7/23/2010

Sophia Antipolis, 23 July 2010: The European Society of Cardiology (ESC) is concerned that interpretations of a paper about cholesterol, published in the Lancet (1), could act to deter ongoing research efforts into developing new therapeutic strategies to increase high density lipoprotein (HDL) cholesterol. Caution, the ESC experts advise, should be displayed in the interpretation of the results.

In the Lancet study, Paul Ridker and colleagues, from Brigham and Women's Hospital (Boston, MA, USA), undertook a retrospective post-hoc analysis of the JUPITER trial. The results show that if a normal, healthy individual has level of low density lipoprotein (LDL), known as "bad cholesterol", substantially lowered with a potent statin, then the level of HDL "good cholesterol" in that person no longer bears any relation to the remaining cardiovascular risk.

The original JUPITER trial (2) was designed to answer the critical question of whether rosuvastatin prevents cardiovascular disease among healthy people with normal LDL cholesterol levels, but increased levels of high-sensitivity C-reactive protein, a marker of chronic low level inflammation, considered a new risk factor for cardiovascular events.

The current Lancet study showed that when 17,802 subjects were divided into quartiles of HDL cholesterol concentrations, HDL cholesterol concentrations were inversely related to vascular risk at the end of study for individuals randomised to placebo, with the top quartile having a 46% reduced risk compared to the bottom quartile (p=0.0039). In contrast, however, among those subjects given active treatment with rosuvastatin, vascular risk was calculated to be similar for subjects in both the top and bottom HDL quartiles (p=0.82)

"Although measurement of HDLcholesterol concentration is useful as part of initial cardiovascular risk assessment, HDL-cholesterol concentrations are not predictive of residual vascular
'/>"/>

Contact: ESC Press Office
press@escardio.org
33-049-294-8627
European Society of Cardiology
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Diabetics Urged to Confer With Their Doctor About Avandia Use
2. New online community launched to help medical practices learn about meaningful use
3. Overwhelming Number of Americans Concerned About Their Weight
4. Los Angeles Alternative Fuel & Auto Expert Available To Speak About Significance of BP Oil Spill
5. Legendary Australian Actor, Garry McDonald Talks to AudioClinic about Hearing Loss
6. Experts Optimistic About Solving Puzzle of Alzheimers
7. Get All Your Questions About Women and Relationships Solved Online At WomanAdvice.com
8. Book Reveals the Truth about Six Pack Abs
9. U of Minnesota study: Americans worried about the quality of Gulf seafood
10. Kids Into Safe Skin (K.I.S.S) Officially Launches Today with a Mission to Create Awareness About Skin Cancer Detection and Prevention
11. Parents Ill-Informed About Kids Concussion Risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... Infectious Diseases (NIAID), part of the National Institutes ... of CRS3123, an investigational oral antibiotic intended to ... ) infection. CRS3123 (previously known as REP3123) is ... while sparing normal intestinal bacteria. , The Phase ... men and women ages 18 to 45 in ...
(Date:7/9/2014)... labels handed out by pharmacists may be misread ... according to new research by the University of ... Blind)., The study, published recently in the ... prescription medications dispensed by pharmacies do not consistently ... simply following recommended guidelines for font size, use ...
(Date:7/9/2014)... A study published in the scientific journal ... Bonin, two researchers at Universit Laval, reveals that it ... method that involves rekindling pain so that it can ... means to alleviate chronic pain. , The researchers from ... universitaire en sant mentale de Qubec (IUSMQ) were inspired ...
(Date:7/8/2014)... similar longevity and cardiovascular health as other healthy mature ... American Journal of Transplantation . The findings may ... the transplant professionals caring for them. , Over the ... 55 years and older has become more common. Given ... disease, the removal of a kidney could make older ...
(Date:7/8/2014)... team of clinicians from Plymouth, UK, and Sydney, Australia, ... July Australia) launched ACEmobile - a free-to-use app to ... ACEmobile is the first of its kind; an iPad-based ... provides support through the whole process, meaning more members ... this type of assessment. Designed by clinicians for clinicians, ...
Breaking Medicine News(10 mins):Health News:NIH launches Phase I clinical trial of novel drug to treat Clostridium difficile infection 2Health News:Most prescription labels fail to meet guidelines, risking dosage errors 2Health News:Discovery of a new means to erase pain 2Health News:Study finds kidney donation safe for healthy older adults 2Health News:New app widens opportunities for dementia assessments 2Health News:New app widens opportunities for dementia assessments 3
... - The New England Regional Spinal Cord Injury Center ... a Spinal Cord Injury Model System (SCIMS) by the ... grants are awarded in five-year cycles by the NIDRR ... sites. NIDRR supports innovative research in the delivery, ...
... Oct. 27 (HealthDay News) -- Americans need to take action ... Thursday. Someone in the world dies of a stroke ... every year. That number is about equivalent to the population ... Centers for Disease Control and Prevention. The agency,s message ...
... Ontarians 65 years and older did not see a dentist ... and a reduced quality of life , a new study ... the Institute for Clinical and Evaluative Sciences (ICES) shows. , ... and affect a person,s ability to chew and digest food ...
... attack (TIA), sometimes referred to as a "mini stroke", were ... first year if their care was co-ordinated by a special ... published in the November issue of the European Journal ... Neurology at Aarhus University Hospital in Denmark studied 306 patients ...
... News) -- Older people who walk more slowly than ... and disability following surgery, according to a new study. ... should assess the elderly differently than younger patients and ... "This approach may lead to a more individualized ...
... has found that a childhood behavioral intervention to lower ... increase consumption of foods that are good sources of ... levels and lower systolic blood pressure when study participants ... for publication in The Endocrine Society,s Journal of ...
Cached Medicine News:Health News:U.S. Health Officials Urge Lifestyle Changes to Cut Stroke Risk 2Health News:Nearly half of Ontario seniors do not see dentists regularly 2Health News:Hospital team significantly reduced risk of further vascular events after 'mini strokes' 2Health News:Hospital team significantly reduced risk of further vascular events after 'mini strokes' 3Health News: Slower Walking Speed Linked to Surgical Risk in Elderly 2Health News: Slower Walking Speed Linked to Surgical Risk in Elderly 3Health News:Childhood diet lower in fat and higher in fiber may lower risk for chronic disease in adulthood 2
(Date:1/14/2014)... HARRISBURG, Pa. , Jan. 14, 2014 Dynamic Healthcare ... ("GMH"), announced today that it acquired Progressive Home Medical Equipment, ... January 7, 2014. The terms of the acquisition were not ... medical equipment ("DME") company providing a wide range of sleep, ...
(Date:1/14/2014)... 14, 2014 Animal Emergency Critical Care, a LifeCentre partner practice, ... is the first in Loudoun County ... Dr. Susan M. Barnes , Medical Director, is a ... Dr. Cole Taylor , are avid scuba divers. "As altitude ...
(Date:1/14/2014)... 2014 NineSigma , Inc., the leading innovation ... Leadership Summit , May 14-16, 2014 at the Global ... . This is the premier ... breakthrough achievements through open innovation. Participants will learn how ...
Breaking Medicine Technology:Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4
... than doubled time without tumor growth and reduced the ... with placebo- Only once-daily oral cancer treatment to directly ... tumor cell division and blood vessel growth- Phase III ... additional cancersEAST HANOVER, N.J., March 30 Novartis announced ...
... Laboratory Response Network (LRN), the national laboratory system charged ... its first decade at its national meeting in Orlando, ... of Public Health Laboratories (APHL), the Centers for Disease ... Investigation (FBI) to test for agents of bioterrorism, the ...
Cached Medicine Technology:Video: Afinitor(R) Approved in US as First Treatment for Patients With Advanced Kidney Cancer After Failure of Either Sunitinib or Sorafenib 2Video: Afinitor(R) Approved in US as First Treatment for Patients With Advanced Kidney Cancer After Failure of Either Sunitinib or Sorafenib 3Video: Afinitor(R) Approved in US as First Treatment for Patients With Advanced Kidney Cancer After Failure of Either Sunitinib or Sorafenib 4Video: Afinitor(R) Approved in US as First Treatment for Patients With Advanced Kidney Cancer After Failure of Either Sunitinib or Sorafenib 5Video: Afinitor(R) Approved in US as First Treatment for Patients With Advanced Kidney Cancer After Failure of Either Sunitinib or Sorafenib 6Video: Afinitor(R) Approved in US as First Treatment for Patients With Advanced Kidney Cancer After Failure of Either Sunitinib or Sorafenib 7Video: Afinitor(R) Approved in US as First Treatment for Patients With Advanced Kidney Cancer After Failure of Either Sunitinib or Sorafenib 8Nation's Laboratory Response Network Marks First Decade of Protecting Public Health 2
Toxoplasma IgM II ELISA....
HSV 1 & HSV 2 DFA Test....
Herpes Simplex Virus 2 IgG ELISA....
Herpes Simplex Virus 1 IgG ELISA....
Medicine Products: