Navigation Links
No 'brakes' -- Study finds mechanism for increased activity of oncogene in certain cancers
Date:1/6/2014

PITTSBURGH, Jan. 6, 2014 The increased activation of a key oncogene in head and neck cancers could be the result of mutation and dysfunction of regulatory proteins that are supposed to keep the gene, which has the potential to cause cancer, in check, according to a new study led by researchers at the University of Pittsburgh School of Medicine. The findings, published in the early online version of the Proceedings of the National Academy of Sciences, suggest a new target for drugs to treat head and neck tumors, as well as other cancers.

Many research teams have found activation and increased signaling of a protein known as Signal Transducer and Activator of Transcription 3 (STAT3) in different kinds of cancers, and it is associated with poor prognosis, said senior author Jennifer Grandis, M.D., Distinguished Professor of Otolaryngology, Pitt School of Medicine, and director of the Head and Neck Program at the University of Pittsburgh Cancer Institute (UPCI), partner with UPMC CancerCenter. In adult tissues, STAT3 triggers the production of other proteins that promote the growth and survival of cancer cells.

"Until now, the question of why STAT3 could be hyperactivated has gone unanswered," Dr. Grandis said. "Our findings reveal a possible mechanism for this abnormal activity, which could help us develop new cancer drugs."

Noting that gene aberrations in STAT3 itself rarely occurred in head and neck cancers, she and her colleagues looked for mutations in other proteins associated with increased activity of STAT3. To be activated, STAT3 must be phosphorylated, meaning a phosphate group is added to it. Many cancer drugs work by inhibiting enzymes called kinases that encourage this process. The team focused instead on the other side of the biochemical seesaw in which enzymes called phosphatases deactivate proteins by removing phosphates.

To their surprise, they found head and neck tumors with elevated STAT3 were associated with mutations
'/>"/>

Contact: Anita Srikameswaran
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Putting the brakes on pain
2. Study: Half of black males, 40 percent of white males arrested by age 23
3. Stratford Career Institute Updates Medical Billing Home Study Course
4. Study identifies factors associated with pain 1 year after breast cancer surgery
5. New Study Shows That Vitamin E May Benefit Alzheimer's Patients in Daily Activities and Savings In CareGiver Time
6. Loyola bioethics study finds medical students concerned about desensitization to dying patients
7. Kessler Foundation awarded grant to study self-generated learning in multiple sclerosis
8. Study identifies potential new strategy to improve odds of corneal transplant acceptance
9. New study: High mortality in Central Southern states most likely due to smoking
10. Contract Research Organization WCCT Global Announces Milestone for Clinical Study Completion
11. As Tylenol Lawsuits Mount, Bernstein Liebhard LLP Notes New Study Finding that Acetaminophen Combined With Alcohol May Increase Risk for Kidney Damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2015)... Rocket Pure , a manufacturer of natural body care ... natural sunscreen. They are offering the sunscreen in both ... with a bonus lip balm sunscreen. , The new products ... Click to see the natural sunscreen on Amazon . , ... with non-nano zinc oxide and provides broad-based protection against UVA ...
(Date:3/28/2015)... March 28, 2015 Coffee could not only ... protect you from gum disease, researchers have found. , They ... disease. , Coffee contains antioxidants. Antioxidants fight gum disease. Does ... researchers at Boston Univ. Henry M. Goldman School of Dental ... August 2014 issue of the Journal of Periodontology. , “This ...
(Date:3/28/2015)... Could genetic code determine someone’s coffee habit? ... by researchers at the Harvard T.H. Chan School of ... the Coffee and Caffeine Genetics Consortium and published ... the study—one of several recent HSPH investigations of the ... than 120,000 regular coffee drinkers of European and African ...
(Date:3/28/2015)... "Necrorun" was featured on NewsWatch as part of ... latest and coolest applications on the market for iOS, ... and technology expert, conducted the app review and shared ... game with knights, nature, and peasants. , The ... to Eurogamer. The popularity of these games grew over ...
(Date:3/28/2015)... (PRWEB) March 28, 2015 Take a ... system kicks into action. Acids tumble into the stomach, ... a faulty valve-like structure lets these acids run amok, ... an extremely common symptom. More than 60 million Americans ... slides examine where heartburn starts, and how it can ...
Breaking Medicine News(10 mins):Health News:Rocket Pure Releases New Natural Sunscreens For Athletes 2Health News:Rocket Pure Releases New Natural Sunscreens For Athletes 3Health News:New Research Impliments Coffee May Help Fight Gum Disease and Increasing Benefits With Tylers Coffee 2Health News:How Coffee Habits Relate to Our Genetic Code and Enhancing the Caffeine Experience 2Health News:How Coffee Habits Relate to Our Genetic Code and Enhancing the Caffeine Experience 3Health News:A Grim Endless Runner Game Was Featured on NewsWatch Television on January 30, 2015 2Health News:Bypass Your Heartburn Worries This Easter With Tylers Coffee 2
... SOA integration, and Complex-Event Processing (CEP) Technologies Unified ... 30 First Choice Professionals, LLC., today announced ... TIBX ), to provide healthcare organizations with ... solution. FCP,s renowned healthcare integration group will combine ...
... Inc. (NYSE: IMA ), a global leader in ... through the merger of rapid diagnostics and health management, announced ... C. DIFF QUIK CHEK COMPLETE (TM) rapid test as ... difficile associated disease (CDAD). This follows TECHLAB(R), Inc.,s recent ...
... Sheets: IMMB) has completed a reverse merger with a ... a 100 to 1 reverse split of stock. ... the total number of issued and outstanding shares to ... IMMB.Immunotech Laboratories, Inc. has indefinite licensing rights of the ...
... at a rate not seen in more than twenty years, creating ... insurance for small business is being called a top priority at ... and (NFIB) and America,s Health Insurance Plans (AHIP). , ... ...
... MONDAY, March 30 (HealthDay News) -- Babies who gain weight ... more prone to obesity as toddlers, Harvard researchers report. , ... much younger," said study author Dr. Elsie M. Taveras. "Even ... start guiding parents about how to prevent rapid weight gain ...
... Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN ) today ... Annual Meeting of Stockholders. Over the past several months, ... independent directors, engaged in a rigorous process to identify ... the Board strongly believes will best serve the interests ...
Cached Medicine News:Health News:First Choice Professionals and TIBCO Announce Strategic Partnership to Advance Healthcare Integration 2Health News:Inverness Medical Innovations Launches New FDA Cleared C. DIFF QUIK CHEK COMPLETE(TM) Rapid Test 2Health News:Inverness Medical Innovations Launches New FDA Cleared C. DIFF QUIK CHEK COMPLETE(TM) Rapid Test 3Health News:Inverness Medical Innovations Launches New FDA Cleared C. DIFF QUIK CHEK COMPLETE(TM) Rapid Test 4Health News:Immunotech Completes Merger Acquisition 2Health News:BestHealthcareRates.com Reports Highest Cancellation Rate of Employee Benefit Plans in More Than Two Decades 2Health News:BestHealthcareRates.com Reports Highest Cancellation Rate of Employee Benefit Plans in More Than Two Decades 3Health News:BestHealthcareRates.com Reports Highest Cancellation Rate of Employee Benefit Plans in More Than Two Decades 4Health News:Rapid Infant Weight Gain Linked to Childhood Obesity 2Health News:Amylin Pharmaceuticals Announces Slate of Directors for Annual Meeting of Stockholders 2Health News:Amylin Pharmaceuticals Announces Slate of Directors for Annual Meeting of Stockholders 3Health News:Amylin Pharmaceuticals Announces Slate of Directors for Annual Meeting of Stockholders 4
(Date:3/27/2015)... 2015 BioCorRx, Inc. ( BICX ... is a healthcare solutions organization, which focuses solely ... $22 billion in the U.S. alone. The Company created a ... in a specially compounded form for outpatient surgical implantation. The ... and New Zealand ) to the specially ...
(Date:3/27/2015)... CHAPEL HILL, N.C. , March 27, 2015 /PRNewswire/ ... function is essential to meeting challenges in clinical development, ... and face tighter regulations, the Medical Affairs function is ... charted by mature markets. According to ... market study participants have a group dedicated to Medical ...
(Date:3/27/2015)... , March 27, 2015  The quality function ... description: ensure products meet quality standards at every stage ... escalating regulations, quality leaders also have the challenge of ... Those who don,t effectively balance these priorities ... well as marketplace failure and regulatory scrutiny. ...
Breaking Medicine Technology:Small Cap IR Correction -- BioCorRx Inc. Positions Itself Through Strategic Partnerships To Gain Market Share Of The $22 Billion Substance Abuse Treatment Market In The U.S. 2Medical Affairs Capabilities Expanding in Emerging Marketplaces 2New Medical Device Quality Study Finds Regulatory Environment is Boosting Quality Spending, Especially for Large Companies 2
... YORK, May 25, 2011 Amgen (NASDAQ: ... ) today announced new results from multiple studies of ... efficacy and safety profile of ENBREL, the most prescribed ... abstracts across four indications, including moderate-to-severe rheumatoid arthritis (RA), ...
... ST. LOUIS, May 25, 2011 Building on its ... Materials Science , a strategic growth initiative of ... the establishment of a permanent endowment through the Materials ... Researcher Award. Intended to honor individuals who have ...
Cached Medicine Technology:Data Presented at Two Global Medical Congresses Reinforce Benefit of Enbrel® (etanercept) for Patients with Chronic Inflammatory Conditions 2Data Presented at Two Global Medical Congresses Reinforce Benefit of Enbrel® (etanercept) for Patients with Chronic Inflammatory Conditions 3Data Presented at Two Global Medical Congresses Reinforce Benefit of Enbrel® (etanercept) for Patients with Chronic Inflammatory Conditions 4Data Presented at Two Global Medical Congresses Reinforce Benefit of Enbrel® (etanercept) for Patients with Chronic Inflammatory Conditions 5Data Presented at Two Global Medical Congresses Reinforce Benefit of Enbrel® (etanercept) for Patients with Chronic Inflammatory Conditions 6Data Presented at Two Global Medical Congresses Reinforce Benefit of Enbrel® (etanercept) for Patients with Chronic Inflammatory Conditions 7Data Presented at Two Global Medical Congresses Reinforce Benefit of Enbrel® (etanercept) for Patients with Chronic Inflammatory Conditions 8Data Presented at Two Global Medical Congresses Reinforce Benefit of Enbrel® (etanercept) for Patients with Chronic Inflammatory Conditions 9Data Presented at Two Global Medical Congresses Reinforce Benefit of Enbrel® (etanercept) for Patients with Chronic Inflammatory Conditions 10Data Presented at Two Global Medical Congresses Reinforce Benefit of Enbrel® (etanercept) for Patients with Chronic Inflammatory Conditions 11Data Presented at Two Global Medical Congresses Reinforce Benefit of Enbrel® (etanercept) for Patients with Chronic Inflammatory Conditions 12Data Presented at Two Global Medical Congresses Reinforce Benefit of Enbrel® (etanercept) for Patients with Chronic Inflammatory Conditions 13Aldrich Materials Science Endows New Materials Research Society Mid-Career Researcher Award 2Aldrich Materials Science Endows New Materials Research Society Mid-Career Researcher Award 3
... ELISA products for autoimmune testing feature single-well ... well as specific reflex tests including dsDNA, ... SS-A (Ro), SS-B (La), Scl-70 and Jo-1. ... a full line of products for Cardiolipins ...
... eye provides stability for contact lenses during ... tabs that are precisely positioned to provide ... sutures. They are constructed from implant grade ... and are compatible with all Volk indirect ...
... glass technologies and designs, the Digital ... views of the mid and far ... will provide image quality previously unattainable ... examination for more detailed and comprehensive ...
Latex agglutination slide test for the qualitative or quantitative determination of Cryptococcus neoformans antigen in CSF and serum....
Medicine Products: