Navigation Links
No association found between vitamin D concentration in blood and risk of prostate cancer
Date:5/27/2008

High vitamin D concentration in the blood is not associated with a reduced risk of prostate cancer, researchers report in an article published online May 27 in the Journal of the National Cancer Institute.

Laboratory studies suggested that high doses of vitamin D may reduce the risk of prostate cancer, but epidemiological studies that have examined the relationship have reported inconsistent results.

In a nested case-control study, Jiyoung Ahn, Ph.D., and Richard Hayes D.D.S., Ph.D., of the National Cancer Institute in Bethesda, Md., and colleagues compared the vitamin D concentrations in the blood of 749 men diagnosed with prostate cancer with that of 781 men without prostate cancer. All of the men were participants in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial and were included in the regular screening arm. Vitamin D concentration was measured in a blood sample taken when the men enrolled in the study, and all prostate cancer cases included in the current analysis were diagnosed 1 to 8 years after the blood samples were taken.

The researchers found that there was no statistically significant difference in the risk of prostate cancer with increasing vitamin D concentration. The researchers did see some evidence of an increased risk of aggressive disease associated with higher concentration of vitamin D, but the trend was not statistically significant and the association did not show a linear dose-dependence.

Results from this large prospective study of men who underwent standardized prostate cancer screening in the context of a screening trial do not support the hypothesis that higher serum vitamin D status is associated with decreased risk of prostate cancer, the authors write. The study showed no association of vitamin D with nonaggressive disease; however, it raises the possibility that higher vitamin D level may be associated with increased risks for aggressive disease, although a clear monotonic doseresponse relationship was lacking.

In an accompanying editorial, Lorelei Mucci, Sc.D., and Donna Spiegelman, Sc.D., of the Harvard School of Public Health in Boston reviewed previous studies that have looked for a possible association between vitamin D and prostate cancer risk. The evidence to date does not strongly support an association between vitamin D status in adulthood and prostate cancer risk. They note that because prostate cancer is often diagnosed at an early stage and as low-grade disease, Ahn and colleagues effort to study the vitamins association with aggressive prostate cancer, which is the most important clinically, is valuable. The editorialists comment, however, that other groups have not seen a similar association, and Ahns data should be viewed in that context.


'/>"/>

Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Ohio Association of Health Plans Names Pinnacle Awards to Programs That Improve Health Care for Ohioans
2. American Lung Association Launches Online Photo Campaign to Expose Big Tobacco in Communities Nationwide
3. The Anxiety Disorders Association of America and The HealthCentral Network Form Alliance to Develop New Online Resources for Anxiety Disorders
4. Analysis of Millions of U.S. Births Shows Association Between Birth Defects and Preterm Birth
5. American Heart Association Ranks Americas Most Heart Friendly Cities for Women
6. Supreme Master Ching Hai International Association Delivering US$160,000 in Aid to Earthquake Survivors in China
7. American Academy of Pediatrics/American Heart Association Clarification of Statement on Cardiovascular Evaluation and Monitoring of Children and Adolescents With Heart Disease Receiving Medications for ADHD
8. Statement from Larry Minnix, President & CEO American Association of Homes and Services for the Aging, On the Government Accountability Offices (GAO) Nursing Home Oversight Report
9. Bankers Life and Casualty Company Named Corporate Honoree at Alzheimers Association Chicago Rita Hayworth Gala
10. The American College of Cardiology, American Heart Association and the Heart Rhythm Society Release Updated Cardiac Device-Based Therapy Guidelines
11. PA Homecare Association kicks off Annual Conference: Homecare advocates speak about the importance of re-balancing the healthcare system to ensure care to the citizens of the state
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned ... developed to enhance the health of felines. The formula is all-natural and is made ... in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery ... of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. , ... for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey ...
(Date:6/25/2016)... ... 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned ... the David Geffen School of Medicine at UCLA. He trained in Internal Medicine at ... fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... people are unfamiliar with. The article goes on to state that individuals are now ... of these less common operations such as calf and cheek reduction. The Los Angeles ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary ... Dallas that it will receive two significant new grants to support its work ... marked its 25th anniversary by recognizing patients, medical professionals and scientists for their ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016  MedSource announced today that it ... software solution of choice.  This latest decision demonstrates ... to their clients by offering a state-of-the-art electronic ... establishes nowEDC as the EDC platform of choice ... clients.  "nowEDC has long been a preferred EDC ...
(Date:6/23/2016)... , June 23, 2016 Research ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, ... (Oral, Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is ... a CAGR of 6.1% in the forecast period 2016 ...
(Date:6/23/2016)... Research and Markets has announced the ... 2016 - Forecast to 2022" report to their offering. ... up to date financial data derived from varied research sources ... with potential impact on the market during the next five ... comprises of sub markets, regional and country level analysis. The ...
Breaking Medicine Technology: