Navigation Links
No association found between vitamin D concentration in blood and risk of prostate cancer
Date:5/27/2008

High vitamin D concentration in the blood is not associated with a reduced risk of prostate cancer, researchers report in an article published online May 27 in the Journal of the National Cancer Institute.

Laboratory studies suggested that high doses of vitamin D may reduce the risk of prostate cancer, but epidemiological studies that have examined the relationship have reported inconsistent results.

In a nested case-control study, Jiyoung Ahn, Ph.D., and Richard Hayes D.D.S., Ph.D., of the National Cancer Institute in Bethesda, Md., and colleagues compared the vitamin D concentrations in the blood of 749 men diagnosed with prostate cancer with that of 781 men without prostate cancer. All of the men were participants in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial and were included in the regular screening arm. Vitamin D concentration was measured in a blood sample taken when the men enrolled in the study, and all prostate cancer cases included in the current analysis were diagnosed 1 to 8 years after the blood samples were taken.

The researchers found that there was no statistically significant difference in the risk of prostate cancer with increasing vitamin D concentration. The researchers did see some evidence of an increased risk of aggressive disease associated with higher concentration of vitamin D, but the trend was not statistically significant and the association did not show a linear dose-dependence.

Results from this large prospective study of men who underwent standardized prostate cancer screening in the context of a screening trial do not support the hypothesis that higher serum vitamin D status is associated with decreased risk of prostate cancer, the authors write. The study showed no association of vitamin D with nonaggressive disease; however, it raises the possibility that higher vitamin D level may be associated with increased risks for aggressive disease, although a clear monotonic doseresponse relationship was lacking.

In an accompanying editorial, Lorelei Mucci, Sc.D., and Donna Spiegelman, Sc.D., of the Harvard School of Public Health in Boston reviewed previous studies that have looked for a possible association between vitamin D and prostate cancer risk. The evidence to date does not strongly support an association between vitamin D status in adulthood and prostate cancer risk. They note that because prostate cancer is often diagnosed at an early stage and as low-grade disease, Ahn and colleagues effort to study the vitamins association with aggressive prostate cancer, which is the most important clinically, is valuable. The editorialists comment, however, that other groups have not seen a similar association, and Ahns data should be viewed in that context.


'/>"/>

Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Ohio Association of Health Plans Names Pinnacle Awards to Programs That Improve Health Care for Ohioans
2. American Lung Association Launches Online Photo Campaign to Expose Big Tobacco in Communities Nationwide
3. The Anxiety Disorders Association of America and The HealthCentral Network Form Alliance to Develop New Online Resources for Anxiety Disorders
4. Analysis of Millions of U.S. Births Shows Association Between Birth Defects and Preterm Birth
5. American Heart Association Ranks Americas Most Heart Friendly Cities for Women
6. Supreme Master Ching Hai International Association Delivering US$160,000 in Aid to Earthquake Survivors in China
7. American Academy of Pediatrics/American Heart Association Clarification of Statement on Cardiovascular Evaluation and Monitoring of Children and Adolescents With Heart Disease Receiving Medications for ADHD
8. Statement from Larry Minnix, President & CEO American Association of Homes and Services for the Aging, On the Government Accountability Offices (GAO) Nursing Home Oversight Report
9. Bankers Life and Casualty Company Named Corporate Honoree at Alzheimers Association Chicago Rita Hayworth Gala
10. The American College of Cardiology, American Heart Association and the Heart Rhythm Society Release Updated Cardiac Device-Based Therapy Guidelines
11. PA Homecare Association kicks off Annual Conference: Homecare advocates speak about the importance of re-balancing the healthcare system to ensure care to the citizens of the state
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... ... 27, 2017 , ... Elisa Guajardo Carothers is not your typical author. She went from working ... nun. Now, she writes about God, when she isn’t swimming as a performing mermaid. , ... is BS! (Before Satan),” she offers a comedic look at the dysfunctions of God’s family, ...
(Date:2/27/2017)... ... 26, 2017 , ... Miro is the ultimate smart media center that offers ... movies, TV shows and much more apps for user exploration. Its innovative acoustic design ... of 1280 x 720 provides crisp images with remarkable clarity and color. The WiFi ...
(Date:2/27/2017)... BC (PRWEB) , ... February 27, 2017 , ... ... drug rehabilitation and alcohol treatment programs in British Columbia, Canada, at https://www.sunshinecoasthealthcentre.ca/ ... to its team. The new hire, Mackenzie Alsager, showcases the Centre's commitment to ...
(Date:2/27/2017)... ... ... New Jersey ranks among the top five states in the entire nation ... advanced services is growing. , Project WE vs C is a focused two-year ... non-profit partners in their fight against cancer and in support of their shared mission ...
(Date:2/26/2017)... ... February 26, 2017 , ... This is an ... world’s first to be ISO/IEC 17025:2005 INAB accredited for Der p 1 (house ... is the globally recognised standard that sets out requirements for the technical competence ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... -- Period October – December 2016 Revenues ... SEK -16.4 (-6.4) million Result after tax amounted to SEK ... dilution Cash flow from operating activities amounted to SEK -8.3 ... Period full year ... Operating result amounted to SEK -39.5 (-29.5) million ...
(Date:2/24/2017)... -- Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), ... the Cowen and Company 37 th Annual Health ... Tuesday, March 7, 2017 at 11:20 a.m. Eastern Time. ... can be accessed at http://wsw.com/webcast/cowen38/zbh .  The webcast ... Zimmer Biomet,s Investor Relations website at http://investor.zimmerbiomet.com . ...
(Date:2/24/2017)...  In conjunction with DURECT Corporation,s (Nasdaq: ... you are invited to listen to a conference call ... Tuesday, March 14, 2017 at 4:30 pm Eastern Time ... webcast of the presentation will be available by accessing ... Relations."  If you are unable to participate during the ...
Breaking Medicine Technology: