Navigation Links
No Osteoarthritis Seen in Obese Mice Without Leptin
Date:9/29/2009

Hormone linked to appetite may also influence arthritis risk, researchers find

TUESDAY, Sept. 29 (HealthDay News) -- The appetite-regulating hormone leptin may contribute to osteoarthritis in obese people, according to a new study that suggests that skeletal wear and tear caused by excess weight isn't the only cause of the painful and debilitating condition.

Duke University researchers found that extremely obese mice didn't develop osteoarthritis if their bodies didn't have leptin. In fact, joints in obese mice without leptin appeared healthier than those in normal mice.

The study appears in the Sept. 29 issue of the journal Arthritis & Rheumatism.

This is the first time that leptin has been identified as a "metabolic link" between obesity and altered cartilage metabolism in joints, according to a university news release.

"Although there was some earlier evidence that leptin might be involved in the arthritis disease process, we didn't think that there would be no arthritis at all" in the obese mice without leptin, said Farshid Guilak, director of orthopedic research in the Duke Department of Surgery, in the news release.

Leptin influences many osteoarthritis-related factors, such as body weight, inflammation and bone metabolism.

"With obesity and osteoarthritis, there are good similarities between humans and mice," Guilak said. "If we can find a pathway that links a high-fat diet with arthritis, then we can try to identify and block the inflammatory mediators that are linked with the dietary fat."

More information

The Arthritis Foundation has more about osteoarthritis.



-- Robert Preidt



SOURCE: Duke University, news release, Sept. 29, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. Study suggests obesity alone does not cause knee osteoarthritis in mice
2. Video: New National Campaign Launched to Raise Awareness of Osteoarthritis of the Knee and Encourage Patients to Get a Kick Out of Life
3. Hormone promises to keep joint injuries from causing long-term osteoarthritis
4. Women with strong thigh muscles protected from symptomatic knee osteoarthritis
5. Collagen-deficient mice show signs of osteoarthritis
6. Cognitive behavioral therapy improves sleep and pain in people with osteoarthritis
7. Biomarker Could Predict Severe Osteoarthritis
8. Protein level may serve as predictor of severe osteoarthritis
9. Detecting early signs of osteoarthritis
10. Excess Weight Speeds Up Osteoarthritis
11. Platelet Rich Plasma Therapy (PRP) Accelerates Healing of Joint Injuries, Osteoarthritis Pain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2017)... ... August 22, 2017 , ... PracticeMatch, a company that provides ... employers connect with physicians and advanced practitioners like nurse practitioners and ... in August through November of this year. The online career fairs will allow job ...
(Date:8/21/2017)... , ... August 21, 2017 , ... FCPX LUT Monochromatic ... Editors can quickly and easily add washed color grades to footage. A LUT is ... changes every pixel’s color to the corresponding color indicated by the table. This pack ...
(Date:8/21/2017)... ... August 21, 2017 , ... Duncan ... program serving the people of Michigan. The new initiative fundraises for the Kalamazoo ... the very forefront of animal protection and welfare by addressing the root causes ...
(Date:8/21/2017)... ... August 21, 2017 , ... San Diego physician and surgeon ... reform plan, has announced his candidacy for the 52nd Congressional District currently held by ... America’s Promise. Coming to this country at age eleven after suffering homelessness and hardship ...
(Date:8/20/2017)... , ... August 20, 2017 , ... ... HIPAA ComplyPAK™ Compliance Management System has assisted multiple clients in successfully ... Public Accountants, Service Organization Control Level 2 (AICPA SOC Level 2), and State ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), ... Board of Directors has approved the payment of a quarterly ... The cash dividend of ... 27, 2017 to stockholders of record as of the close ... are subject to approval of the Board of Directors and ...
(Date:8/4/2017)... Aug. 3, 2017  Agragen, LLC, a ... in the biopharmaceutical, nutraceutical, and aquacultural feed sectors, ... its lead drug candidates, AGR131.  This drug is ... from the blood of patients suffering from inflammatory ... bowel disease. ...
(Date:8/2/2017)... WASHINGTON , Aug. 2, 2017 CaryRx, a ... same day delivery service for patients in the ... the traditional retail pharmacy by providing delivery of medications through ... scheduled for future delivery or delivered within one hour to ... "We are excited to bring this invaluable service to ...
Breaking Medicine Technology: