Navigation Links
No Link Between Anti-Nausea Drug, Heart Trouble
Date:9/24/2007

Current warning for droperidol unwarranted, study suggests

MONDAY, Sept. 24 (HealthDay News) -- The current "black box" label warning for the anti-vomiting drug droperidol -- cautioning users against an increased risk of irregular heartbeat with use of the medication -- may be unnecessary, Mayo Clinic researchers conclude.

In late 2001, the U.S. Food and Drug Administration issued a black box warning regarding the risk of heart trouble called prolonged QT in surgical patients receiving droperidol. Prolonged QT can lead to a potentially fatal arrhythmia called torsades de pointes (TdP).

The authors of this study analyzed data on almost 140,000 patients who had surgery before the 2001 black box warning, plus 150,000 patients who had surgery after 2001. Before the black box warning, 12 percent of patients (about 16,791) received the drug. No patients received the drug after the warning.

The rate of prolonged QT, TdP, or sudden death (within 48 hours after surgery) among the first group of patients was 1.66 percent and 1.46 percent in the second group of patients. Overall, there were no documented cases of TdP among patients who took droperidol.

"We found no change in bad heart rhythms with the commonly used low-dose droperidol versus no droperidol use in a very large number of surgical patients," lead author Dr. Gregory A. Nuttall, of the Mayo Clinic in Rochester, Minn., said in a prepared statement.

He and his colleagues concluded that the black box warning for droperidol is "excessive and unnecessary."

The study is published in the October issue of the journal Anesthesiology.

More information

The Arizona Center for Education and Research on Therapeutics has more about TdP.



-- Robert Preidt



SOURCE: American Society of Anesthesiologists, news release, Sept. 24, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. CDC reveals relationship between prepregnant weight and heart defects in infants
2. Genetic differences found between Male and Female brains
3. Link between Constipation and Parkinsons Disease
4. Is there a link between bones and memory?
5. Comparison between warfarin and aspirin
6. No link between blood groups and prostate cancer
7. Link Between Infection And Heart Disease
8. Link between chlorine byproducts and pregnancy risks
9. No link between bad weather and rheumatism
10. Prescription Drug Use Varies Widely Between States
11. No connection between breast cancer and pill
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... While it’s often important to take certain medications during the night, finding ... identified a solution. , She developed a prototype for MOTION LIGHT-UP PILL BOX to ... the need to turn on a light when taking medication during the night, allowing ...
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of ... ElderCounsel, a national organization of elder law and special needs planning attorneys. “Membership in ... It also provides a forum to network with elder law attorneys nationwide,” said Somekh. ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids this ... by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited about ... ages; it is a non-competitive, non-timed event, which is all about having fun and ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and ... of published author, William Nowers. Captain Nowers and his wife, Millie, have six ... years in the Navy. Following his career as a naval aviator and carrier ...
(Date:10/12/2017)... ... 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one of ... innovative new design of the shoulder pad. The shoulder pad provides optimal support ... your pain while using cold therapy. By utilizing ice and water that is circulated ...
Breaking Medicine News(10 mins):
(Date:9/12/2017)... and NEW YORK , Sept. 12, 2017   ... for global supply chains, has published the first annual edition of its ... of more than 20,400 companies evaluated by EcoVadis, based on Scorecard Ratings ... 2016. ... CSR Risk & Performance Index ...
(Date:9/12/2017)... 2017  ValGenesis Inc., the global leader in ... to announce the appointment of Dr. Ajaz ... of Directors and Chairman of Advisory Board beginning ... companies to manage their entire validation lifecycle process ... this process. Furthermore, ValGenesis VLMS enables rigorous compliance, ...
(Date:9/9/2017)... Sept. 8, 2017 Dealmed Medical Supplies, ... of medical equipment, supplies, drugs, vaccines, and specialty medical ... into an agreement to acquire Vantage Medical Supplies, a ... Holtsville, New York . ... new and emerging medical practices, will operate under the ...
Breaking Medicine Technology: