Navigation Links
No Increase in Clots With Drug-Eluting Stents
Date:3/29/2009

Risk appears the same for bare metal or drug-eluting devices, study found,,

SUNDAY, March 29 (HealthDay News) -- Despite initial concerns that stent thrombosis, a blood clot inside a stent, is more common with the drug-eluting device, there appears to be no difference in the clot risk for either drug-eluting or bare metal stents, a large new study found.

After a heart attack, many patients undergo a treatment called angioplasty, which opens the blocked coronary artery that caused the attack. With many of these procedures, the stent, a metallic mesh tube that props open the narrowed artery, is also inserted and left in place.

"We had a thrombosis rate of 3.3 percent over a year, which sounds high, but these are patients with acute [heart attacks] getting a stent," lead researcher Dr. George Dangas, an associate professor of medicine at Columbia University Medical Center in New York City, said during a Sunday morning teleconference at the American College of Cardiology's annual scientific sessions in Orlando, Fla. "So it's not that high after all."

"With any type of bare metal stent or drug-eluting stent, there was no difference after one year," Dangas added.

Bare metal stents -- as the name implies -- are bare tubes of metal mesh. Drug-eluting stents, in addition to keeping the artery open, slowly release a medication to prevent the build-up of scar tissue inside the stent.

A stent thrombosis can block blood flow through the stent and cause another heart attack or even death. Concerns have been raised that stent thrombosis might be more common in drug-eluting stents than bare-metal ones.

Dangas and his colleagues looked at data on 3,202 patients who participated in the HORIZONS-AMI trial; these patients received either bare metal stents or drug-eluting stents.

During the year after treatment, 107 patients (3 percent) developed stent thrombosis. The rate of stent thrombosis was the same for those treated with bare metal and those with drug-eluting stents, the researchers found.

Also, there was no difference in the rate of patients developing stent thrombosis whether they were taking the blood thinner Angiomax (bivalirudin) or heparin plus glycoprotein IIb/IIIa inhibitors, which also help prevent clots from forming.

Although patients treated with Angiomax had a higher rate of acute stent thrombosis, both groups had equal rates of stent thrombosis after a month, the researchers reported.

Dangas's group also collected information on factors that could lead to stent thrombosis, such as smoking, insulin-treated diabetes, implanting several stents, treatment of ulcerated lesions and complete blockage of the artery responsible for the heart attack.

For these patients, high doses of the anti-clotting drug Plavix (clopidogrel) protected against stent thrombosis.

A related presentation Saturday at the cardiology conference found that patients with coated stents had fewer cases of serious complications. The study -- the largest one ever to evaluate "real-world" stent patients -- included 217,675 patients over age 65 with coated stents and 45,025 patients with bare-metal devices, the Wall Street Journal reported.

The study found that patients with coated stents were significantly less susceptible to non-fatal heart attacks or death. And there were slightly fewer cases of repeat procedures with coated stent patients, while stroke rates were about the same in both groups of patients, the newspaper said.

More information

To learn more about stents, visit the American Heart Association.



SOURCES: March 29, 2009, teleconference with George Dangas, M.D., Ph.D, associate professor of medicine, Columbia University Medical Center, New York City; March 29, 2009, presentation, American College of Cardiology's annual scientific sessions, Orlando, Fla.


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. US Spinal Nonfusion Procedures Set to Increase Nearly Five Times From 2008 to 2013, According to Millennium Research Group
2. 3-drug chemotherapy combination increases organ preservation in patients with larynx cancer
3. Grand Canyon University Increases Academic Scholarships
4. AORN and Mercy Ships Collaborate to Increase Patient Care Aboard Hospital Ships
5. Despite Patent Expiries of Leading Therapies, New Product Launches Will Drive a $4.6 Billion Increase in the Coronary Heart Disease Market
6. GeoFitness Physical/Mental Stimulus Plan Helps Increase Results in School State Standardized Tests
7. Pennsylvania Sees Increase in Tuberculosis, Emphasizing Need for Awareness
8. Alcohol flush signals increased cancer risk among East Asians
9. Cathepsin B increases apoptosis in fulminant hepatic failure
10. How to increase the efficacy of local excision of rectal cancer
11. Stent 4 Life: A campaign is launched to increase the use of primary PCI in acute coronary patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... ... ... Journal of Pain Research has seen a significant increase in its ranking ... Scopus database (Elsevier B.V.) and is a measure of a journal's impact. It takes ... year period and also the importance of the journals where the citations came from. ...
(Date:2/11/2016)... , ... February 11, 2016 , ... ... will discuss how to improve care by making data on heart procedures public ... The Summit on Transparency and Public Reporting of Pediatric and Congenital Heart Disease ...
(Date:2/11/2016)... NJ (PRWEB) , ... February 11, 2016 , ... ... the call for nominations seeking candidates for the Board of Commissioners. Individuals interested ... passion, skills and experience with diversity of clinical practice settings and across allied ...
(Date:2/11/2016)... ... February 11, 2016 , ... Colorado spine surgeon, Donald Corenman, ... 334 spine surgeons to know in 2016 . The list consists of spine surgeons ... surgery. , Dr. Corenman understands the importance of clinical excellence; he has been ...
(Date:2/11/2016)... ... February 11, 2016 , ... The annual list showcases the ... of DataPoint’s team dedication and commitment to the SharePoint ecosystem. A panel ... list. The panel’s goal is to recognize and promote technology entrepreneurship. , The ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... Scientists from Silicon Biosystems Menarini today ... door to genetic analysis of previously preserved tumor ... isolate with 100 percent purity. Utilizing the com­pany,s ... various stages of development, the researchers were able ... are clinically relevant, and may change the way ...
(Date:2/11/2016)... 11, 2016  AcelRx Pharmaceuticals, Inc. (NASDAQ: ACRX ... made at the 38th annual John A. Boswick ... which is being held February 14-18, 2016 in ... latest advancements in wound healing, burn care, and infection ... Australian-New Zealand Burns Association, Academy of Physicians in Wound ...
(Date:2/11/2016)... 2016  Ampio Pharmaceuticals, Inc. (NYSE MKT: AMPE) announced ... a Controlled Equity Offering SM Sales Agreement with ... Macaluso , Chairman and CEO, stated "During our most ... currently raising money and that we have enough money ... still complete all of our current objectives and nothing ...
Breaking Medicine Technology: