Navigation Links
No Increase in Clots With Drug-Eluting Stents
Date:3/29/2009

Risk appears the same for bare metal or drug-eluting devices, study found,,

SUNDAY, March 29 (HealthDay News) -- Despite initial concerns that stent thrombosis, a blood clot inside a stent, is more common with the drug-eluting device, there appears to be no difference in the clot risk for either drug-eluting or bare metal stents, a large new study found.

After a heart attack, many patients undergo a treatment called angioplasty, which opens the blocked coronary artery that caused the attack. With many of these procedures, the stent, a metallic mesh tube that props open the narrowed artery, is also inserted and left in place.

"We had a thrombosis rate of 3.3 percent over a year, which sounds high, but these are patients with acute [heart attacks] getting a stent," lead researcher Dr. George Dangas, an associate professor of medicine at Columbia University Medical Center in New York City, said during a Sunday morning teleconference at the American College of Cardiology's annual scientific sessions in Orlando, Fla. "So it's not that high after all."

"With any type of bare metal stent or drug-eluting stent, there was no difference after one year," Dangas added.

Bare metal stents -- as the name implies -- are bare tubes of metal mesh. Drug-eluting stents, in addition to keeping the artery open, slowly release a medication to prevent the build-up of scar tissue inside the stent.

A stent thrombosis can block blood flow through the stent and cause another heart attack or even death. Concerns have been raised that stent thrombosis might be more common in drug-eluting stents than bare-metal ones.

Dangas and his colleagues looked at data on 3,202 patients who participated in the HORIZONS-AMI trial; these patients received either bare metal stents or drug-eluting stents.

During the year after treatment, 107 patients (3 percent) developed stent thrombosis. The rate of stent thrombosis was the same for those treated with bare metal and those with drug-eluting stents, the researchers found.

Also, there was no difference in the rate of patients developing stent thrombosis whether they were taking the blood thinner Angiomax (bivalirudin) or heparin plus glycoprotein IIb/IIIa inhibitors, which also help prevent clots from forming.

Although patients treated with Angiomax had a higher rate of acute stent thrombosis, both groups had equal rates of stent thrombosis after a month, the researchers reported.

Dangas's group also collected information on factors that could lead to stent thrombosis, such as smoking, insulin-treated diabetes, implanting several stents, treatment of ulcerated lesions and complete blockage of the artery responsible for the heart attack.

For these patients, high doses of the anti-clotting drug Plavix (clopidogrel) protected against stent thrombosis.

A related presentation Saturday at the cardiology conference found that patients with coated stents had fewer cases of serious complications. The study -- the largest one ever to evaluate "real-world" stent patients -- included 217,675 patients over age 65 with coated stents and 45,025 patients with bare-metal devices, the Wall Street Journal reported.

The study found that patients with coated stents were significantly less susceptible to non-fatal heart attacks or death. And there were slightly fewer cases of repeat procedures with coated stent patients, while stroke rates were about the same in both groups of patients, the newspaper said.

More information

To learn more about stents, visit the American Heart Association.



SOURCES: March 29, 2009, teleconference with George Dangas, M.D., Ph.D, associate professor of medicine, Columbia University Medical Center, New York City; March 29, 2009, presentation, American College of Cardiology's annual scientific sessions, Orlando, Fla.


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. US Spinal Nonfusion Procedures Set to Increase Nearly Five Times From 2008 to 2013, According to Millennium Research Group
2. 3-drug chemotherapy combination increases organ preservation in patients with larynx cancer
3. Grand Canyon University Increases Academic Scholarships
4. AORN and Mercy Ships Collaborate to Increase Patient Care Aboard Hospital Ships
5. Despite Patent Expiries of Leading Therapies, New Product Launches Will Drive a $4.6 Billion Increase in the Coronary Heart Disease Market
6. GeoFitness Physical/Mental Stimulus Plan Helps Increase Results in School State Standardized Tests
7. Pennsylvania Sees Increase in Tuberculosis, Emphasizing Need for Awareness
8. Alcohol flush signals increased cancer risk among East Asians
9. Cathepsin B increases apoptosis in fulminant hepatic failure
10. How to increase the efficacy of local excision of rectal cancer
11. Stent 4 Life: A campaign is launched to increase the use of primary PCI in acute coronary patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/26/2017)... ... ... Ballad of Cowboy Justin”: a charming tale of a brave cowboy who saves the ... published author, Leah Westbrook, a wife and mother who loves to spend time with ... tale about a young brave cowboy, Cowboy Justin, who saves the town from a ...
(Date:9/26/2017)... ... September 26, 2017 , ... “Childhood Memories of a Virginia Wanderer”: an ... help them relive their own youth. “Childhood Memories of a Virginia Wanderer” is the ... Navy for nine years. He received his BS from Idaho State University in ...
(Date:9/26/2017)... ... ... Tour Guide”: is the life story of the author and the exciting times this adventurer ... is an adventure tour guide and the subject of the book. , “Quickly slapping ... shocked faces. I played it off as a part of the adventure tour, an “added ...
(Date:9/26/2017)... ... ... Boobie and Ceebie”: a tool families can use to teach children about the love of ... G.S. White, a devoted follower of Jesus Chris who is married with one son. ... only for children but also to glorified God in everything he does.” --G.S. White , ...
(Date:9/25/2017)... ... September 26, 2017 , ... Your World Insurance Services, ... 2017 and began fulfilling a life-long wish of owner Stacy Boyle to give back ... recipient of help when I was in high school,” said Ms. Boyle. “My father ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)...  As the latest Obamacare repeal effort moves is ... (R-LA) and Lindsey Graham (R-SC) medical device ... industry is in an odd place.  The industry wants ... tax on medical device sales passed along with the ... increased visits and hospital customers with the funding to ...
(Date:9/19/2017)... ANN ARBOR, Mich. , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical ... the precise destruction of targeted tissues, announced three leadership team developments today:   ... Josh Stopek, PhD ... ... Veteran medical device executive ...
(Date:9/18/2017)... Mich. , Sept. 18, 2017  PMD Healthcare ... Specialty Pharmacy of Kalamazoo, Mich. , ... hub service that expedites and streamlines patient and provider ... PD 2.0, and wellness management services.  ... device used to measure lung function for a variety ...
Breaking Medicine Technology: