different trials, is never as good as a randomized trial," he explained. Such a trial would be desirable, he said, because there are gender-related differences in blood vessels and cells.
"Women have more reactive platelets, and more delicate blood vessels," Faxon said.
But both Faxon and Berger said they do not consider the gender of a patient when they prescribe clopidogrel.
However, including women in studies of antiplatelet drugs is important, Berger said, because clopidogrel is expected to be available in a less-expensive, generic version, which will widen its use, and because more powerful antiplatelet medications are just becoming available.
More information
The U.S. National Library of Medicine has more on the benefits and risks of clopidogrel.
SOURCES: Jeffrey S. Berger, M.D., assistant professor, medicine, and director, cardiovascular thrombosis, New York University Langone Medical Center, New York City; David P. Faxon, M.D., vice chairman, medicine, Brigham and Women's Hospital, Boston; Nov. 17, 2009, Journal of the American College of Cardiology
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