Navigation Links
No Evidence That Lithium Helps in ALS
Date:4/6/2010

New study contradicts previous report that led to drug's off-label use

TUESDAY, April 6 (HealthDay News) -- The drug lithium doesn't delay progression of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, and shouldn't be used to treat patients with the disease, researchers say.

The findings from a new study contradict promising results from a small pilot study that led to a high level of off-label use of lithium to treat people with ALS, a fatal motor neuron condition. Traditionally, lithium is used to treat bipolar affective disorder.

Currently, there is no cure for ALS. The only approved drug for treatment of ALS is riluzole, which has been shown to extend patients' lives by an average of three months.

In the new study, American and Canadian researchers randomly assigned 84 ALS patients to receive either riluzole and a placebo or riluzole and lithium. The trial was stopped early after initial findings suggested that lithium would have little or no effect.

"Although a modest benefit of lithium was not ruled out by the study . . . we found no evidence that lithium in combination with riluzole slows progression of ALS more than riluzole alone," wrote Dr. Swati Aggarwal from Massachusetts General Hospital in Boston and Dr. Lorne Zinman of Sunnybrook Health Sciences Center in Toronto, and colleagues.

"At this time, there remains no convincing evidence for the use of lithium as a treatment for patients with ALS," they concluded in a statement.

The study findings were released online April 5 in advance of publication in the May print issue of The Lancet Neurology.

More information

The ALS Association has more about amyotrophic lateral sclerosis.



-- Robert Preidt



SOURCE: The Lancet Neurology, news release, April 5, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Evidence-based medicine theory can be applied to frequent flying says US professor
2. Elseviers Journal of Evidence-Based Dental Practice celebrates 10th year with special issue
3. Pew Applauds Federal Grant Program Supporting State Expansion of Evidence-Based Home Visitation
4. Palladians Distinguished Clinicians Present at APTAs National CSM Convention in San Diego on Evidenced Informed Management of Chronic Low Back Pain Without Surgery
5. Cellular pathway could provide evidence of how cancer and obesity are linked
6. More Evidence That Swings in Blood Pressure Raise Stroke Risk
7. Researchers find further evidence linking Epstein-Barr virus and risk of multiple sclerosis
8. Evidence-based care and outcomes improve at Get With The Guidelines-Stroke hospitals
9. Hayes Announces Appointment Of Dr Susan Levine To The Medicare Evidence Development and Coverage Advisory Committee (MEDCAC)
10. Aleres Dr. Michael Taitel Presents Compelling Evidence at IBI/NBCH Health & Productivity Forum that Wellness Programs Positively Impact Health & Productivity
11. New Scientific Studies Show Further Evidence of Avandia Dangers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... , ... “America On The Brink”: the Christian history of the United States ... creation of published author, William Nowers. Captain Nowers and his wife, Millie, have ... thirty years in the Navy. Following his career as a naval aviator and ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of ... announced today its plans to open a flagship location in Covington, LA at 401 ... Rooms To Go store next to Office Depot in the Holiday Square shopping center. ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... The American ... Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium ... 8. , In honor of Morris F. Collen, a pioneer in the field of ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa Mohebi, the Los ... article to the newly revamped Cosmetic Town journal section, featuring articles ... procedure known as Follicular Unit Extraction (FUE). , Dr. Mohebi says ...
(Date:10/12/2017)... , ... October 12, 2017 , ... On Saturday, October ... treadmill relay – Miles by Moonlight to raise money for the American Heart Association ... more. , Teams will work together to keep their treadmills moving for 5 ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... 28, 2017 Cohen Veterans Bioscience and Early ... of wearable and home sensors for real-time monitoring of ... Foundation, a nonprofit organization focused on disruptive health solutions ... affordable analytical system to record and integrate behavioral, cognitive, ... ...
(Date:9/23/2017)... Pa. , Sept. 22, 2017 Janssen ... a complete response letter from the U.S. Food and ... seeking approval of sirukumab for the treatment of moderately ... letter indicates additional clinical data are needed to further ... moderately to severely active RA. ...
(Date:9/18/2017)... KALAMAZOO, Mich. , Sept. 18, 2017 ... , and OptiMed Specialty Pharmacy of Kalamazoo, ... offer a strategic hub service that expedites and streamlines ... personal spirometer, Spiro PD 2.0, and wellness management services.  ... is a medical device used to measure lung function ...
Breaking Medicine Technology: