Navigation Links
No Difference in Rate of Survival for Children of Different Races Undergoing Liver Transplantation, but Long-Term Results Not as Good for African-American Adults
Date:10/29/2008

Research to be presented Saturday, November 1, 2008 at this year's liver

meeting in San Francisco, California, October 31 - November 4

SAN FRANCISCO, Oct. 29 /PRNewswire/ -- Two studies presented at the annual meeting of the American Association for the Study of Liver Diseases paint a different picture of survival based on racial group for adult and child recipients of liver transplants.

Researchers at the Baylor College of Medicine used a United Network for Organ Sharing dataset of 2700 pediatric liver transplant recipients age 17 years and under to determine if there were any differences in survival between racial groups -- Caucasians, Hispanics, African-Americans, and Asians. They looked at graft and patient survival for the period between 2002 and 2007, and found that, although there were differences in leading cause for inclusion on the transplant list, age at time of transplant, and sex of transplant recipients, there was no difference in either allograft or patient survival rate between the racial groups. Similarly, they found no difference in PELD/MELD score (a standard scoring system for disease severity) at time of transplant and percentage of patients undergoing multiorgan transplants.

"The finding that children in the current era have no disparities in outcomes was quite surprising, since our study is a small part of a larger research project that examined both adult and pediatric transplantation outcomes and found African-Americans faring significantly worse at three years following transplantation," said the study's presenter Natasha Becker, MD.

A study conducted by researchers at the Mayo Clinic also found differences in long-term survival rate among racial groups for adult transplant recipients. This study examined race of the transplant recipients, transplant centers, and payer status. All 11565 single-organ liver transplant recipients from 2003 to 2005 were included in one of four groups -- African-American, Caucasian, Asian/Pacific Islander, or other.

Researchers found no difference in short-term survival in patient and graft, but they did find significant differences after two years. The center in which the transplant was performed accounted for some of the discrepancy, but after controlling for that, African-Americans were found to have a lower patient and graft survival rate compared to the other three groups. The authors found no explanation for this based on transplant center, payer, or disease severity pretransplantation.

The Mayo Clinic researchers were also surprised by the results. "Since our previous study has demonstrated that race had no effect on posttransplantation survival in select, academic centers in the US," said Young-Suk Lim, MD, PhD, "we had hypothesized that the different outcome after liver transplantation between races in US would disappear after stratification by centers. But, lower long-term posttransplantation outcome of African-American remained after multivariable adjustment for center, payer, or pretransplantation disease severity."

"Perhaps elucidating the differences between the pediatric and adult populations will allow us to understand the disparities that are seen in the adult population," said Dr. Becker. Dr. Lim is also looking to future studies to explain the racial disparity, "We are in the process of investigating the issue of center-specific effect a bit deeper. If the center is not the reason, further investigation into potential genetic differences may be warranted."

Abstract titles:

1. Racial disparities in patient survivals after pediatric liver transplantation

2. Relationship between recipient race and transplant predictors of outcome following liver transplantation

AASLD is the leading medical organization for advancing the science and practice of hepatology. Founded by physicians in 1950, AASLD's vision is to prevent and cure liver diseases. This year's Liver Meeting, held in San Francisco, California, October 31- November 4, will bring together more than 7,000 researchers from 55 countries.

A pressroom will be available from November 1 at the annual meeting. For copies of abstracts and press releases, or to arrange for pre-conference research interviews, contact Gregory Bologna at 703-299-9766. To pre-register, call Ann Tracy at 703-299-9766.

Press releases and all abstracts are available online at http://www.aasld.org.

This release was issued through The Xpress Press News Service, merging e-mail and satellite distribution technologies to reach business analysts and media outlets worldwide. For more information, visit http://www.XpressPress.com


'/>"/>
SOURCE American Association for the Study of Liver Diseases
Copyright©2008 PR Newswire.
All rights reserved

Related medicine news :

1. Majority of voters say election outcome will make a great deal of difference on key issues
2. Towson Student Wins Courage Award, Turns Facial Differences Into Positive Tool
3. Researchers find differences in swallowing mechanism of Rett syndrome patients
4. Gender differences and heart disease
5. States Scorecard Finds Big Differences in Kids Health Care
6. Dialysis Catheter Placement Makes Little Difference in Infection Risk
7. Global study reveals differences in standard of care for osteoporosis across the world
8. UNICEF: Every Second Can Make a Difference to Myanmars Children; 20% Already Suffering from Diarrhea, Malaria reported
9. Depression diversity: Brain studies reveal big differences among individuals
10. National Hemophilia Foundation Asks America to Make a Difference With National Fundraising Initiative
11. Growth Hormone is Used to Treat Twice as Many Short Boys Than Girls in the U.S. and Asia; Gender Difference is Smaller in the Rest of the World
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... PawPaws ... a new product that was developed to enhance the health of felines. The formula ... , The two main herbs in the PawPaws Cat Kidney Support Supplement ...
(Date:6/25/2016)... ... ... Austin residents seeking Mohs surgery services, can now turn to Dr. Jessica Scruggs ... for medical and surgical dermatology. , Dr. Dorsey brings specialization to include Mohs surgery, ... Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn Goldstein, MD, ...
(Date:6/25/2016)... ... ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors in ... School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green Hospital ... at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train in ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
(Date:6/24/2016)... ... 2016 , ... The Pulmonary Hypertension Association (PHA) learned during ... two significant new grants to support its work to advance research and patient ... recognizing patients, medical professionals and scientists for their work in fighting pulmonary hypertension ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...  Collagen Matrix, Inc., ("Collagen Matrix") the driving ... collagen and mineral based medical devices for tissue ... Messer has joined the company as Vice ... growing portfolio of oral surgery, neurosurgery, orthopaedic and ... the Collagen Matrix executive team as an accomplished ...
(Date:6/24/2016)... June 24, 2016   Bay Area Lyme ... Dean Center for Tick Borne Illness , ... Rehabilitation, MIT Hacking Medicine, University of California, Berkeley, ... announced the five finalists of Lyme Innovation ... More than 100 scientists, clinicians, researchers, entrepreneurs, and ...
(Date:6/24/2016)... -- Research and Markets has announced ... Applications, Technologies, Forecasts" report to their offering. ... Smart Skin, Structural Health Monitoring, Composite Smart Structures, ... involves electronic and/or electrical components and circuits that ... such as vehicle bodies or conformally placed upon ...
Breaking Medicine Technology: