Navigation Links
No Benefit Seen in Extending Herceptin for Breast Cancer

FRIDAY, Dec. 7 (HealthDay News) -- For women with a specific type of breast cancer, taking Herceptin for a year after initial treatment is just as effective -- and safer -- than staying on it for a longer period, new research suggests.

Many of the women in the study, who had HER2-postive early stage breast cancer, were cancer-free eight years later and experienced no major heart problems, the international study on Herceptin (trastuzumab) found.

"Giving trastuzumab for [two years] did not improve disease-free or overall survival, compared with one year of trastuzumab treatment," study author Dr. Martine Piccart, president of the European Society for Medical Oncology and chairwoman of the Breast International Group, said in a news release from the American Association for Cancer Research.

The study was run by the Breast International Group and Roche, the maker of Herceptin.

HER2-positive cancers are a particularly aggressive form of the disease and occur in 20 percent of breast cancer diagnoses, according to the U.S. National Cancer Institute.

The new phase 3 trial involved more than 5,000 women from several countries. After completing initial treatment for their early stage HER2-positive breast cancer, the women were randomly assigned to received Herceptin every three weeks for one year, two years or not at all.

Although the two-year treatment was no more effective than one year, heart problems occurred more frequently among the women who received Herceptin for the longer period. Most of the heart problems were reversible when the treatment was stopped, the researchers said.

The study proved "that a significant proportion of patients treated with trastuzumab ... are alive and free of disease recurrence after a median follow-up of eight years," said Piccart, who is chief of the medicine department at the Jules Bordet Institute in Brussels, Belgium.

"It is also reassuring with regard to the low cardiac toxicity of trastuzumab when given after adjuvant chemotherapy," she added. "Finally, it confirms that one year of adjuvant trastuzumab should remain the standard of care in women with HER2-positive early breast cancer."

The research was scheduled for Friday presentation at the 2012 San Antonio Breast Cancer Symposium. The data and conclusions should be viewed as preliminary until published in a peer-reviewed journal.

More information

The U.S. Centers for Disease Control and Prevention has more about breast cancer treatment.

-- Mary Elizabeth Dallas

SOURCE: American Association for Cancer Research, news release, Dec. 7, 2012

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Tafamidis: Approval denotes proven added benefit
2. Heart failure patients with diabetes may benefit from higher glucose levels
3. Adding drug to standard chemotherapy provides no survival benefit for older lung cancer patients
4. Avastin No Benefit to Older Lung Cancer Patients: Study
5. Talking to Yourself Could Have Mental Benefits
6. Study examines benefit of follow-up CT when abdominal ultrasound inconclusive
7. Research examines when benefits of screening mammography outweigh the harms for women in their 40s
8. Study finds that patient education videos viewed before an operation may benefit patients
9. Everyday fish oil capsule may provide kidney-related benefits
10. Erectile dysfunction drug may benefit cardiac function in young patients with heart defects
11. Study shows benefit of new maintenance therapy for multiple myeloma
Post Your Comments:
Related Image:
No Benefit Seen in Extending Herceptin for Breast Cancer
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Those who ... with these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, ... Marne, Michigan, has released tools for healthy coping following a traumatic event. , Trauma ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her son ... lash out at his family verbally and physically. , “When something upset him, he couldn’t ... would use it. He would throw rocks at my other children and say he was ...
(Date:6/24/2016)... ... , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys ... peers for this recognition are considered among the top 2 percent of lawyers practicing ... members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their ... Award, an essay contest in which patients and their families pay tribute to a ... the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)...  VMS Rehab Systems, Inc. ( ) reported ... required to build a strong and stable market for ... on the OTC Markets-pink current trading platform. ... are seeing an anomaly in market trading activities that ... the Company, but shareholders and market players as well. ...
(Date:6/24/2016)... 24, 2016   Bay Area Lyme Foundation ... Dean Center for Tick Borne Illness , Harvard ... MIT Hacking Medicine, University of California, Berkeley, and ... the five finalists of Lyme Innovation , ... than 100 scientists, clinicians, researchers, entrepreneurs, and investors ...
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016  American Respiratory ... testing company, is now able to perform sophisticated lung assessments in ... Medical Technologies , Inc. Patients are no longer ... to ndd,s EasyOne PRO ® , ARL patients like Jeanne R. ... testing done in the comfort of her own home. ...
Breaking Medicine Technology: