Navigation Links
Nitric oxide impacts source of sickle cell pain crisis
Date:5/9/2011

AUGUSTA, Ga. - Nitric oxide gas appears to directly impact the source of the classic, disabling pain crises of sickle cell disease, Georgia Health Sciences University researchers report.

The short-acting gas helps unglue hemoglobin molecules that stick together, forming long chains that ultimately deform red blood cells and prompting a cellular pileup in small blood vessels and pain, said Dr. C. Alvin Head, Chairman of GHSU's Department of Anesthesiology.

The findings get scientists closer to understanding why red blood cells sickle and potentially to a easy-to-use, non-addictive treatment that helps avoid it, said Dr. Tohru Ikuta, GHSU molecular hematologist.

Hydroxyurea, which prompts the body to make more fetal hemoglobin which cannot sickle, is currently the only approved therapy for sickle cell. Patients with recurring pain crises typically must take increasingly higher doses of stronger narcotics to deal with the pain.

Head and his colleagues envision instead an inhaler like asthmatics use that enables them to breathe in nitric oxide when they feel a pain crisis coming on. "Drugs just mask the symptoms," Head said. "We have mounting evidence that nitric oxide directly addresses the source of pain crises to help patients avoid them."

They've shown in a small patient sample that inhaling nitric oxide appears safe and effective. The study of 18 patients in Atlanta, Chicago and Detroit published in 2010 in the American Journal of Hematology showed that the half who inhaled nitric oxide for four hours had better pain control than those receiving only the standard self-administered morphine.

The new study examined nitric oxide's impact from many angles and showed that it appears to disperse dense, solid chains of hemoglobin troublemakers. Once a significant number of hemoglobin molecules stick together, it causes red blood cells to distort from their natural round shape that easily maneuvers blood vessels to a s
'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Exercise protects the heart via nitric oxide
2. Nitric Oxide Doesnt Seem to Help Preemies Lungs: Report
3. Researchers show that nitric oxide-donating naproxen can boost colorectal cancer prevention
4. Nitric oxide-releasing wrap for donor organs and cloth for therapeutic socks
5. The safety of daily magnesium oxide treatment for children with chronic constipation
6. Firefly glow: Berkeley Lab scientists develop a hydrogen peroxide probe based on firefly luciferin
7. Carbon Monoxide May Be Greater Threat in Winter
8. Iron oxide nanoparticles becoming tools for brain tumor imaging and treatment
9. As Summer Heats Up, Glacier Creme Debuts the Ultimate in Natural Sunscreen: 'Naked Protection' with Zinc Oxide
10. DTWI's Travel Carbon Monoxide Detector Prevents Carbon Monoxide Poisoning Whilst Holidaying Abroad, or in the UK
11. Study: Carbon Monoxide Exposure Can be Reduced During Routine Anesthesia in Kids
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nitric oxide impacts source of sickle cell pain crisis
(Date:1/22/2015)... 22, 2015 The City of West Hollywood hosted ... to commemorate the 42nd anniversary of the Supreme Court decision Roe ... been 42 years since the Roe vs. Wade decision and the ... present as ever,” said City of West Hollywood Councilmember Abbe Land. ...
(Date:1/22/2015)... The Incredible Bulk is a revolutionary method put together ... by up to 30lbs in less than 12 weeks without ... Stevenson, prompting an investigative review. , “Our Incredible Bulk ... formula that allows the body to pack on a massive ...
(Date:1/22/2015)... Orlando, Florida (PRWEB) January 22, 2015 ... up today at the 2015 PGA Merchandise Show to ... lady and incredible female amateur golfer, Arlene McKitrick. The ... career female amateur golf tournament win. She won her ...
(Date:1/22/2015)... January 22, 2015 Carinsurancesavings.biz has released a ... death and dismemberment insurance . , Purchasing an accidental ... be very advantageous. This type of rider provides benefits if ... can be considered a lesser form of life insurance. ...
(Date:1/22/2015)... Florida (PRWEB) January 22, 2015 IsoComforter, Inc. ... therapy machine with patented IsoTube design to treat specific body ... introduced the most progressive and easy to use patented cold ... post-operative and sports related orthopedic and muscle injuries. IsoComforter ...
Breaking Medicine News(10 mins):Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2
... coronary artery stenosis, according to a large study performed ... , The study consisted of 1,331 patients who ... stenosis. 10,561 coronary artery segments were analyzed during the ... significant coronary artery stenosis in our patients; specificity was ...
... used a new imaging technique to take high quality ... in mice, and the technology could help in the ... may cause blindness. , The study, "The Clinical Time-Course ... with Histologic and Cellular Infiltrate Correlation," was published in ...
... Hopkins University has received a $4.97 million grant from ... initial phase of a unique program aimed at improving ... with the Johns Hopkins Center for Global Health, and ... Uganda. As part of the initiative, the faculties of ...
... OAKLAND, Calif., Dec. 1 As President Bush seeks,to ... which will especially,adversely impact healthcare services and workplace safety, ... new,website inviting web browsers to help "send Bush packing,", ... The site offers an interactive game highlighting some of ...
... Dec. 1 Mach One Corporation,(Pink Sheets: MNCN), a ... long term benefit to the agricultural and consumer,market, announced ... Board,of Directors effective upon the closing of the acquisition ... Mr. Ballantyne is ...
... For difficult to diagnose patients,Breast-Specific Gamma Imaging (BSGI) is ... ultrasound for patients who need additional imaging,following a questionable ... meeting of the Radiological Society of North America (RSNA).,BSGI ... lesions independent,of tissue density and discover very early stage ...
Cached Medicine News:Health News:New technique captures high-res images of full retina 2Health News:Johns Hopkins and Makerere University to collaborate on African health education initiative 2Health News:Johns Hopkins and Makerere University to collaborate on African health education initiative 3Health News:Citing 'Midnight Rules' to Erode Health and Safety, Nurses Unveil New Website to Send Bush Packing 2Health News:Mr. Tad Ballantyne to Join Mach One Board of Directors 2Health News:Molecular Breast Imaging Performs Better Than Ultrasound in Patients With Mammographic Abnormalities 2
(Date:1/23/2015)... plc (NYSE: MNK ) announced today that ... program. The open-ended authorization permits the company to repurchase ... "Funding additional initiatives and seeking attractive ... to pursue a range of focused growth strategies," said ...
(Date:1/22/2015)... 22, 2015  BiOptix is pleased to announce the appointment ... of Chemistry and Biochemistry. Scott joins the company after previous ... Amgen throughout the course of his nearly 20 year ... is a nationally recognized thought leader in the biosensor ...
(Date:1/22/2015)... Jan. 22, 2015  Bio-Techne Corporation (NASDAQ: TECH ... first member of the new Simple Plex platform through ... launch represents the re-branding of the previously acquired CyPlex ... platform is a transformative immunoassay technology which integrates an ...
Breaking Medicine Technology:Mallinckrodt plc Announces Share Repurchase Program 2Mallinckrodt plc Announces Share Repurchase Program 3Mallinckrodt plc Announces Share Repurchase Program 4BiOptix Expands Leadership Team with the Appointment of Dr. Scott Klakamp as Vice President of Chemistry and Biochemistry 2Bio-Techne Launches Simple Plex Platform 2Bio-Techne Launches Simple Plex Platform 3
... M1 is an advanced desktop PC ... is a sophisticated 2 channel stimulation ... electrical stimulations, 2 sound stimulations and ... You can customize each stimulation independently. ...
... high performance magnetic stimulator for use in both ... ,MagPro is able to stimulate with repetition rates ... field/nerve interface can be done using the ability ... direction. , , , , ,MagPro is ...
... X-SIZER System is a ... for thrombus removal in ... saphenous vein grafts. ... cutter and,continuous evacuation. ...
... Allura Xper is the perfect partner for ... these systems are scalable to meet your ... come.,Flexibility means that your Allura Xper FD20 ... cardiac use. Openness to new technologies allows ...
Medicine Products: