Navigation Links
Nitric oxide impacts source of sickle cell pain crisis
Date:5/9/2011

AUGUSTA, Ga. - Nitric oxide gas appears to directly impact the source of the classic, disabling pain crises of sickle cell disease, Georgia Health Sciences University researchers report.

The short-acting gas helps unglue hemoglobin molecules that stick together, forming long chains that ultimately deform red blood cells and prompting a cellular pileup in small blood vessels and pain, said Dr. C. Alvin Head, Chairman of GHSU's Department of Anesthesiology.

The findings get scientists closer to understanding why red blood cells sickle and potentially to a easy-to-use, non-addictive treatment that helps avoid it, said Dr. Tohru Ikuta, GHSU molecular hematologist.

Hydroxyurea, which prompts the body to make more fetal hemoglobin which cannot sickle, is currently the only approved therapy for sickle cell. Patients with recurring pain crises typically must take increasingly higher doses of stronger narcotics to deal with the pain.

Head and his colleagues envision instead an inhaler like asthmatics use that enables them to breathe in nitric oxide when they feel a pain crisis coming on. "Drugs just mask the symptoms," Head said. "We have mounting evidence that nitric oxide directly addresses the source of pain crises to help patients avoid them."

They've shown in a small patient sample that inhaling nitric oxide appears safe and effective. The study of 18 patients in Atlanta, Chicago and Detroit published in 2010 in the American Journal of Hematology showed that the half who inhaled nitric oxide for four hours had better pain control than those receiving only the standard self-administered morphine.

The new study examined nitric oxide's impact from many angles and showed that it appears to disperse dense, solid chains of hemoglobin troublemakers. Once a significant number of hemoglobin molecules stick together, it causes red blood cells to distort from their natural round shape that easily maneuvers blood vessels to a sickle-shape. At that point, red blood cells also become uncharacteristically sticky.

They found nitric oxide reduced the length of the unnatural hemoglobin strands, made the strands more fragile and, using a high-powered confocal microscope, they could see it also helped cells regain a more normal shape. Studies were done on human cells in vitro.

Next steps include fine-tuning the dose and learning more about why red blood cells become sticky. Head notes that with a gas, it's a lot more tricky to determine how much drug gets into the blood than with an oral or intravenous delivery. They already have evidence that in sickle cell disease red and white blood cells stick together, which they should not.

They believe their findings about how these cells clog up vessels will have broad applications for a number of clot-based conditions, including the increased clot risk that follows surgery. "Really what we are learning is the basic understanding of early clot formation," Head said.


'/>"/>

Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

Related medicine news :

1. Exercise protects the heart via nitric oxide
2. Nitric Oxide Doesnt Seem to Help Preemies Lungs: Report
3. Researchers show that nitric oxide-donating naproxen can boost colorectal cancer prevention
4. Nitric oxide-releasing wrap for donor organs and cloth for therapeutic socks
5. The safety of daily magnesium oxide treatment for children with chronic constipation
6. Firefly glow: Berkeley Lab scientists develop a hydrogen peroxide probe based on firefly luciferin
7. Carbon Monoxide May Be Greater Threat in Winter
8. Iron oxide nanoparticles becoming tools for brain tumor imaging and treatment
9. As Summer Heats Up, Glacier Creme Debuts the Ultimate in Natural Sunscreen: 'Naked Protection' with Zinc Oxide
10. DTWI's Travel Carbon Monoxide Detector Prevents Carbon Monoxide Poisoning Whilst Holidaying Abroad, or in the UK
11. Study: Carbon Monoxide Exposure Can be Reduced During Routine Anesthesia in Kids
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nitric oxide impacts source of sickle cell pain crisis
(Date:1/24/2017)... ... January 24, 2017 , ... ... during the Annual Enrollment Period (AEP) and the Open Enrollment Period (OEP). 2016 ... insurance coverage. Mainly, people are witnessing higher deductibles, rising premiums, and few choices ...
(Date:1/24/2017)... , ... January 24, 2017 , ... ... newest technology offering, Processing Assurance Control Equipment (PACE), at the International Production and ... , PeroxyChem’s booth will highlight the new technology that is used in poultry ...
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... ... product “Lacto-Freedom” was recently accepted as a Registered Trademark by the United States ... from using a similar name which could confuse consumers into thinking that other ...
(Date:1/24/2017)... , ... January 24, 2017 , ... Learn to use ... athletics or even in relationships. Course offered by Dr. Carol Francis at PVNET ... to limited seating and the many hands-on experiences. , Dr. Carol Francis ...
(Date:1/24/2017)... ... January 24, 2017 , ... Seceon , the only ... real-time, today announced a strategic partnership with Paramount , the Middle East’s ... protect their critical information assets and infrastructure, in a comprehensive and cost effective ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... , January 24, 2017 For today, ... GENE ), Alder Biopharmaceuticals Inc. (NASDAQ: ... ), and Egalet Corp. (NASDAQ: EGLT ). These ... lower on Monday, January 23 rd , 2017, with the ... health care companies in the S&P 500 also were down ...
(Date:1/24/2017)... YORK , Jan. 23, 2017 Laboratory ... the global use of mass spectrometry in both clinical ... current ,MS analysis, global market size of $6.8 billion ... the next four years, profiles the use of mass ... encompassing 21 countries. This study investigated growth in the ...
(Date:1/24/2017)... , January 23, 2017 ArisGlobal, ... life sciences, announces agClinical 3.3, the latest version of ... enables life science organizations to confidently and efficiently meet ... better manage the electronic trial master file so that ... ...
Breaking Medicine Technology: