Navigation Links
Nipping metastases in the bud
Date:12/7/2011

The proliferation of metastases is often the main cause of complications and death from cancer. For the first time, researchers are looking very closely at the development of these metastases themselves, instead of focusing on the "primary" cancers from which they originated. In doing so, a team from the Swiss Center for Experimental Cancer Research (ISREC), at EPFL, was able to isolate a protein that plays a major role in metastasis development, and showed that the formation of secondary cancers could be prevented by blocking this protein. Their results will be published December 7, 2011, in the advance online edition of the journal Nature and will open the door to new therapeutic options for treating late stage cancers.

A vital protein for metastases

The researchers already knew that cancer cells spread widely throughout the body once a malignant tumor is established. These cells don't always result in a secondary cancer, however. It turns out that all cancer cells aren't created equal: only some of them, known as "cancer stem cells," can initiate metastases. And in order to do this, they must settle into a spot a niche that is conducive for their development.

The ISREC team was able to show that several conditions are necessary for cancer to propagate. "In particular, we were able to isolate a protein, periostin, in the niches where metastases develop," explains Joerg Huelsken, holder of the EPFL Debiopharm Chair in Signal Transduction in Oncogenesis. "Without this protein, the cancer stem cell cannot initiate metastasis; instead, it disappears or remains dormant."

Minimal side effects in mice

Periostin exists naturally as part of the extracellular matrix, and has been shown to play a role in fetal development. In adults, it is only active in specific organs the mammary glands, bones, skin and intestine. This research appears to prove that it plays an essential role in the environment that a cancer stem cell needs in order to develop a metastasis. Mice that were bred to lack this protein are resistant to metastasis formation. "We developed an antibody that adheres to this protein, making it inoperative, and we are hoping in this way to be able to block the process of metastasis formation," says Huelsken.

These experiments that blocked the periostin protein resulted in very few side effects in the mice. "This doesn't necessarily mean the same will hold true in humans," the researcher cautions. "We're not even sure that we'll be able to find an equivalent antibody that will work in humans."

This discovery is nonetheless very encouraging, especially since we now know that malignant tumors tend to spread more quickly than was previously believed. Preventing the development of metastases would thus appear to be an important therapeutic option that could limit the deleterious effects of cancers.


'/>"/>
Contact: Emmanuel Barraud
emmanuel.barraud@epfl.ch
41-21-693-07-52
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert  

Related medicine news :

1. Start spreading the news: NYU scientists find therapeutic target to stop cancer metastases
2. Whole body MRI is highly accurate in the early detection of breast cancer metastases
3. Only 5 percent of cancer research funds are spent on metastases, yet it kills 90 percent of all cancer patients
4. Tumors bring their own support cells when forming metastases
5. Fox Chase researchers uncover new risk factors for brain metastases in breast cancer patients
6. ASTRO publishes palliative radiotherapy for bone metastases guideline
7. UNC physician-scientist receives grant to study breast cancer brain metastases
8. Radionuclide treatment against small tumors and metastases
9. New bone-targeting drug delays onset of metastases in hormone-resistant prostate cancer patients
10. Bone-strengthening drug gives pain relief in prostate cancer bone metastases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nipping metastases in the bud
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: